Core 2: Clinical Resource Core

核心 2：临床资源核心

• 批准号: 10573247
• 负责人: Kathleen Lombard Poston
• 金额: $ 27.77万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10573247
• 关键词: Abbreviations; Alzheimer' s Disease; Alzheimer' s disease related dementia; Archives; Autopsy; Award; Brain; Cerebrospinal Fluid; Cerebrovascular Trauma; Clinical; Clinical Research; Consensus; Data; Dementia with Lewy Bodies; Diagnostic; Diagnostic tests; Disasters; Enrollment; Evaluation; Health; Individual; Lewy Body Disease; Lipoproteins; Neuropsychological Tests; Neuropsychology; Parkinson Disease; Parkinson' s Dementia; Participant; Proteins; Public Health; Research; Research Infrastructure; Research Institute; Resource Allocation; Resources; Review Committee; Sampling; Source; Spinal Puncture; Test Result; Therapeutic; Time; Ventricular; Work; clinical diagnosis; clinical diagnostics; extracellular vesicles; nervous system disorder; neuroimaging; neuropathology; next generation; programs; translational proteomics

Abstract Alzheimer's disease (AD) is a major threat to health of older individuals and is a looming public health disaster. Needed solutions in diagnostics and therapeutics will come only through research. Our contribution to this overall project is to provide clinical resources to support the Projects. This includes consensus clinical diagnosis, systematic neuropsychological test results, neuroimaging data, CSF obtained by research quality lumbar puncture, and brain autopsy. Our Core will leverage existing clinical research infrastructure provided by the Stanford AD Center and the Stanford Udall Center. Additional samples also will be provided by our long-time collaborators, Dr. Doug Galasko from the UCSD AD Center, and Dr. Thomas Beach from Banner Research Institute. The Clinical Resource Core's Specific Aims are: 1) Consensus Clinical Diagnosis and Neuropsychological Test Results, 2) CSF Samples and 3) Brain Autopsy .

摘要 阿尔茨海默病（AD）是对老年人健康的主要威胁，并且是迫在眉睫的公共卫生灾难。 诊断和治疗所需的解决方案只能通过研究来实现。我们对此的贡献 整体计划的目的，是提供临床资源，以支持有关计划。这包括共识临床 诊断、系统神经心理学测试结果、神经影像学数据、研究质量获得的CSF 腰椎穿刺和脑部解剖 我们的核心将利用现有的临床研究基础设施提供的斯坦福大学AD中心和 斯坦福大学尤德尔中心。我们的长期合作者道格博士也将提供额外的样本 加州大学圣地亚哥分校AD中心的Galasko和班纳研究所的托马斯·海滩博士。临床 资源核心的具体目标是：1）共识临床诊断和神经心理测试结果，2） CSF样本和3）脑尸检 .