Core 2: Clinical Resource Core

核心 2：临床资源核心

• 批准号: 10573247
• 负责人: Kathleen Lombard Poston
• 金额: $ 27.77万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10573247
• 关键词: Abbreviations; Alzheimer' s Disease; Alzheimer' s disease related dementia; Archives; Autopsy; Award; Brain; Cerebrospinal Fluid; Cerebrovascular Trauma; Clinical; Clinical Research; Consensus; Data; Dementia with Lewy Bodies; Diagnostic; Diagnostic tests; Disasters; Enrollment; Evaluation; Health; Individual; Lewy Body Disease; Lipoproteins; Neuropsychological Tests; Neuropsychology; Parkinson Disease; Parkinson' s Dementia; Participant; Proteins; Public Health; Research; Research Infrastructure; Research Institute; Resource Allocation; Resources; Review Committee; Sampling; Source; Spinal Puncture; Test Result; Therapeutic; Time; Ventricular; Work; clinical diagnosis; clinical diagnostics; extracellular vesicles; nervous system disorder; neuroimaging; neuropathology; next generation; programs; translational proteomics

Abstract Alzheimer's disease (AD) is a major threat to health of older individuals and is a looming public health disaster. Needed solutions in diagnostics and therapeutics will come only through research. Our contribution to this overall project is to provide clinical resources to support the Projects. This includes consensus clinical diagnosis, systematic neuropsychological test results, neuroimaging data, CSF obtained by research quality lumbar puncture, and brain autopsy. Our Core will leverage existing clinical research infrastructure provided by the Stanford AD Center and the Stanford Udall Center. Additional samples also will be provided by our long-time collaborators, Dr. Doug Galasko from the UCSD AD Center, and Dr. Thomas Beach from Banner Research Institute. The Clinical Resource Core's Specific Aims are: 1) Consensus Clinical Diagnosis and Neuropsychological Test Results, 2) CSF Samples and 3) Brain Autopsy .

摘要