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Dual Modality X-ray Luminescence CT for in vivo Cancer Imaging

用于体内癌症成像的双模态 X 射线发光 CT

基本信息

批准号：
10360435
负责人：
Lei Xing
金额：
$ 56.91万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-12-01 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10360435
关键词：
Algorithms Anatomy Animals Biochemistry Biodistribution Biological Biological Markers Biological Process Biomedical Research Characteristics Clinical Research Code Collimator Computational Science Detection Development Diffuse Drug Kinetics Epidermal Growth Factor Receptor Evaluation Fluorescence Foundations Future Geometry Goals Human Hybrids Image Imaging Device Imaging Techniques Imaging technology In Vitro Information Systems Knowledge Light Magnetic Resonance Imaging Measurement Measures Mechanics Medical Medicine Methods Modality Modification Molecular Molecular Probes Morphologic artifacts Mus Optics Pattern Performance Photons Physics Radio Research Research Personnel Resolution Roentgen Rays Sampling Sensitivity and Specificity Series Signal Transduction Source Surface System Systems Development Systems Integration Techniques Testing TimeLine Tissues X-Ray Computed Tomography anatomic imaging animal imaging base biomedical imaging cancer imaging clinical application cost data acquisition design detector experimental study human imaging image reconstruction imaging modality imaging study imaging system in vivo innovation instrumentation interest luminescence malignant breast neoplasm molecular imaging multidisciplinary multiplexed imaging nanoparticle nanophosphor novel optical imaging prototype quantitative imaging quantum reconstruction screening simulation tomography tool transmission process

项目摘要

Dual Modality CT/X-ray Luminescence CT for in vivo Cancer Imaging ABSTRACT A combined X-ray CT and molecular imaging system, referred to as “CT/X-ray luminescence CT (XLCT)”, is proposed. The system uses X-ray as a single source to image anatomy and molecular features from simultaneous detection of luminescence signals of X-ray activatable molecular probes. In this technique, the spatial information is obtained by exciting the sample using spatially selective X-ray patterns while optical detectors placed around the sample measure luminescence photons diffusing out. Regardless of where these photons are detected, it is known that they are created somewhere on the path of the coded X-ray beams. This fundamental principle constitutes a new paradigm for imaging deep-seated light-emitting probes, with little background from tissue auto-fluorescence. Another significant advantage of XLCT is that X-ray excitation is amplified by orders of magnitude because of the extremely high quantum yield (2-4 orders of magnitude greater than 100%) of the radioluminescent materials. Toward establishing XLCT for various biomedical applications and eventually for clinical applications, we have assembled a multidisciplinary team consisting of leading investigators with expertise in CT imaging, molecular imaging, biochemistry, medical physics, computational science, and medicine, and established research themes that unify the common interests and expertise of these investigators. If successful, the hybrid CT/XLCT will overcome many of the limitations of CT and optical imaging methods and enable us to visualize biological processes in the anatomical CT image context with unprecedented sensitivity, specificity and spatial resolution. The novel dual modality imaging strategy will therefore significantly advance the field of cancer imaging and provide a valuable imaging tool for biological and clinical studies.

双模态CT/ x射线发光CT在体内肿瘤成像中的应用