Radioluminescence dosimetry solution for precision radiation therapy

用于精准放射治疗的放射发光剂量测定解决方案

• 批准号: 10418642
• 负责人: Lei Xing
• 金额: $ 47万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10418642
• 关键词: 3D Print; Algorithms; Automation; Biocompatible Coated Materials; Calibration; Cancer Patient; Characteristics; Clinic; Clinical; Clinical assessments; Collaborations; Collimator; Communities; Complex; Consumption; Country; Data; Data Analyses; Data Collection; Dose; Electron Beam; Ensure; Environment; Feedback; Future; High-Dose Rate Brachytherapy; Image; Imaging Techniques; Incidence; Industrialization; Intensity-Modulated Radiotherapy; Light; Linear Accelerator Radiotherapy Systems; Malignant Neoplasms; Manuals; Measurement; Measures; Methods; Modality; Modernization; Monte Carlo Method; Nature; Operative Surgical Procedures; Optics; Patients; Performance; Photons; Positioning Attribute; Procedures; Process; Radiation; Radiation Accidents; Radiation Oncology; Radiation therapy; Research; Roentgen Rays; Safety; Series; Signal Transduction; Software Tools; Surface; System; Technology; Testing; Therapeutic; Time; Water; Work; analytical tool; base; checkpoint therapy; chemotherapy; clinical application; clinical research site; clinically translatable; cost; data acquisition; design; digital; dosimetry; human error; image guided radiation therapy; imaging system; improved; indexing; novel; novel strategies; optical imaging; palliation; programs; proton therapy; prototype; quality assurance; real-time images; response; success; therapy development; tool

Radioluminescence dosimetry solution for precision radiation therapy Project summary Radiation therapy (RT) is an important modality for cancer management. Clinically, over 60% of all cancer patients in the US receive RT each year as therapy or for palliation, or as an adjunct to surgery or chemotherapy. There is also increased evidence that RT in combination with checkpoint immunotherapy is highly effective in treating a subset of cancer patients. In practice, however, because of the invisible nature of X-ray and its complex interaction process with media, how to ensure the geometric and dosimetric accuracy of incident RT beams presents a significant challenge in precision RT and critically determines the success of patient treatment. In this project, we form an academic-industrial collaboration to investigate and create a clinically translatable solution for substantially improved RT quality assurance (QA) using a radioluminescence imaging technique recently developed at Stanford. On the basis of our promising preliminary work, we hypothesize that the accuracy, efficacy and cost of geometric and dosimetric QA measurements of linear accelerators (LINACs) can be substantially improved with the use of radioluminecsnce imaging strategy. With the proposed research, we anticipate that submillimeter accuracy in geometric measurements and better than 3% accuracy in dosimetric measurements will be readily achievable with orders of magnitude less time and effort as compared to current practice, removing a major workflow bottleneck in clinical QA and reducing potential radiation treatment errors. This research presents a first-of-its-kind machine QA strategy capable of instantaneously measuring complex geometric and dosimetric characteristics of LINACs. If successful, the partnership will lead to a much safer and more efficient radiation oncology practice, and enable patients to truly benefit from modern RT modalities such as VMAT and IMRT and SBRT. In addition, the proposed strategy is quite general and the system developed here will also be valuable for QA applications of other treatment modalities, such as proton therapy and high-dose rate (HDR) brachytherapy.

用于精确放射治疗的放射发光剂量测量解决方案 项目摘要 放射治疗（RT）是癌症管理的重要方式。临床上，超过60%的 美国的癌症患者每年接受RT作为治疗或缓解，或作为手术的辅助手段， 化疗还有越来越多的证据表明，RT与检查点免疫疗法相结合， 对治疗一部分癌症患者非常有效。然而，实际上，由于无形的 X射线的性质及其与介质的复杂相互作用过程，如何保证X射线的几何 入射RT射束的剂量测定精度在精密RT中提出了重大挑战， 决定了患者治疗的成功。在这个项目中，我们形成了一个学术-工业合作 研究并创建一个临床上可翻译的解决方案，以大幅提高RT质量保证 (QA)利用斯坦福大学最近开发的放射发光成像技术。根据我们的 有希望的初步工作，我们假设，准确性，效率和成本的几何和 使用这种方法，可以大大改善直线加速器（LINAC）的剂量测定QA测量 放射性发光成像策略。根据这项研究，我们预计亚毫米波 几何测量的准确度和剂量测定测量的准确度将优于3%， 与目前的做法相比，很容易以数量级更少的时间和精力实现， 这是临床QA和减少潜在放射治疗错误的主要工作流程瓶颈。这 一项研究提出了一种能够即时测量复杂的机器QA策略， LINAC的几何和剂量学特性。如果成功的话，这种伙伴关系将带来很大的 更安全，更有效的放射肿瘤学实践，使患者真正受益于现代RT VMAT、IMRT和SBRT等模式。此外，拟议的战略相当笼统， 这里开发的系统对于其他治疗方式的QA应用也是有价值的，例如 如质子治疗和高剂量率（HDR）近距离放射治疗。