DASSIM-RT and Compressed Sensing-Based Inverse Planning

NIH R01(PA 11-260)：DASSIM-RT和基于压缩感知的逆向规划 项目摘要 该项目的目标是建立一种密集角度采样和稀疏强度的新范式- 调制放射治疗(DASSIM-RT)。在该方案中，冗余或可有可无的调制 利用压缩传感(CS)技术有效地去除了入射强度调制光束。这个 以这种方式节省的传输时间被用于增加角度采样，以改善剂量一致性。通过 在角度采样和强度调制之间取得平衡，DASSIM-RT使我们能够充分利用 现代数字直线加速器产生可输送的高度共形剂量分布的能力 效率很高。具体地说，我们将1)建立基于压缩感知(CS)的逆处理框架 计划；2)研究一种名为DASSIM-RT的新型治疗方案；3)展示 DASSIM-RT通过一系列幻影病例和既往治疗的患者。DASSIM-RT代表了一个真正的 具有不折中的角度采样(包括非共面光束)、光束强度的最佳RT方案 调制，以及可能的场特定能量和准直器角度。如果成功，该项目将使我们能够 克服现有治疗方案的许多限制，以满足未满足的高度临床需求 放射肿瘤学中的适形剂量分布。

NIH R01 (PA 11-260): DASSIM-RT and Compressed Sensing-Based Inverse Planning Project Summary The goal of this project is to establish a novel paradigm of dense angularly sampled and sparse intensity- modulated radiation therapy (DASSIM-RT). In this scheme, the redundant or dispensable modulation of the incident intensity-modulated beams is removed effectively by using a compressed sensing (CS) technique. The delivery time saved in this way is used to increase the angular sampling for improved dose conformality. By balancing the angular sampling and intensity modulation, DASSIM-RT enables us to fully utilize the technical capabilities of modern digital linacs to produce highly conformal dose distributions that can be delivered efficiently. Specifically, we will 1) set up a compressed sensing (CS)-based framework for inverse treatment planning; 2) investigate a new type of treatment scheme termed DASSIM-RT; and 3) show the advantage of DASSIM-RT through a series of phantom cases and previously treated patients. DASSIM-RT represents a truly optimal RT scheme with uncompromised angular sampling (including non-coplanar beams), beam intensity modulation, and possible field-specific energy and collimator angle. If successful, the project will allow us to overcome many of the limitations of existing treatment schemes to meet the unmet clinical demand for highly conformal dose distributions in radiation oncology.