Novel Macaque Breeding Runs at the New Iberia Research Center

路易斯安那大学拉斐特分校新伊比利亚研究中心(NIRC)的目标是扩大其 猕猴繁育能力由建造2栋多经营的住宅楼完成，屋面，电力， 水、暖气和空气循环。这种类型的建筑经过了专门的设计和广泛的测试 在德克萨斯州的另一个设施中饲养猕猴，证明其充分性、易维护性和 施工工期。每个建筑单元将包括20个室内/室外跑道，能够很容易地容纳 到20只繁育动物，每只动物的总容量约为800只繁殖者及其后代。这一扩张至关重要 为了适应NIRC快速增长的研究计划以及NIAID VRC和NIAID VRC和 以艾滋病毒/艾滋病为重点的项目。NIRC支持许多关于慢病毒的现场和协作计划 由最先进的成像能力支持的发病机制，包括全身信号细胞分析 旨在治愈艾滋病毒的治疗方法，以及预防粘膜病毒的广泛方案 通过保护性实验疫苗、阴道和结直肠杀微生物剂获得。此外，NIRC一直在 是新冠肺炎疫苗和抗体治疗测试的关键贡献者。后一种流行病已经严重地 耗尽了研究猕猴的供应，NIRC一直在通过增加2200只猕猴来扩大其殖民地 在过去的5年里，非人类灵长类动物。这是通过逐渐改变黑猩猩的用途来适应的 住房用于育种和研究空间，但这种转换已经达到了极限，NIRC已经达到了 猴子住房的最大容量，部分原因是增加了2个新的毛里求斯殖民地 食蟹猴和非洲绿猴，并被授予NIAID SIV疫苗评价单位奖。 增加这种特殊类型住房的理由是它的多功能性、低维护和成本 节省人力：位于路易斯安那州南部的NIRC有能力在户外为猕猴提供住所 全年用于饲养目的，虽然采用传统的鸡笼设计，但在卫生方面表现突出 在有限的等级压力下，猕猴的行为发育也有一些缺陷 拟议中的新建筑将避免，包括缺乏二次围堵，对 最近偶尔出现的零度以下的天气，以及我们的市政水务条例征收的“雨税”。 玉米床房屋目前以典型的后宫配置支持多达10只恒河猴的繁育群体 每个玉米地有一只雄性。按照建议使用更大规模的饲养场，将使&gt；1500只猕猴饲养员的规模扩大 在现场，最大限度地利用经过验证的雄性繁殖者。现场有超过8500只非人类灵长类动物，NIRC是 美国最大的灵长类设施，虽然没有得到NIH的直接支持，但有一个迅速扩大的研究 计划和现成的扩建空间，我们认为NIRC是扩建的理想地点 为美国国立卫生研究院的研究提供支持的猕猴育种。

The New Iberia Research Center (NIRC) at the University of Louisiana at Lafayette is aiming to expand its macaque breeding capacity by the construction of 2 multi-run housing buildings complete with roofing, electricity, water, heating and air circulation. This type of building has been specifically designed and extensively tested for macaque housing/breeding at another facility in Texas, attesting to the adequacy, ease of maintenance and duration of construction. Each building unit will comprise 20 indoor/outdoor runs able to easily accommodate up to 20 breeder animals each for a total capacity of ~800 breeders and their offsprings. This expansion is critical to accommodate the rapidly increasing research programs at NIRC as well as the support of NIAID VRC and SVEU HIV/AIDS focused programs. NIRC supports many both onsite and collaborative programs on lentiviral pathogenesis supported by state of the art imaging capabilities including a whole body to signal cell analysis approach, therapeutic approaches aimed at curing HIV, and an extensive program to prevent mucosal viral acquisition via protective experimental vaccines, vaginal and colorectal microbicides. In addition, NIRC has been a key contributor to the testing of COVID-19 vaccines and antibody treatments. The latter pandemic has severely depleted the supply of research macaques and NIRC has been expanding its colonies via the addition of 2200 nonhuman primates over the past 5 years. This has been accommodate by gradually repurposing chimpanzee housing into breeding and research space, but this conversion has reached its limits and NIRC has reached it maximum capacity as far as monkey housing, in part due to the addition of a 2 new colonies of Mauritian cynomolgus macaques and African green monkeys and the award of a NIAID SIV Vaccine Evaluation Unit award. The rationale for adding this particular type of housing is based on its versatility, low maintenance and cost savings on manpower: Located in Southern Louisiana, NIRC has the ability to house rhesus macaques outdoors year-round for breeding purposes, though the traditional corncrib cage design, while outstanding for sanitation and the behavioral development of macaques, with limited hierarchical stress, also has a number of drawbacks that the proposed new buildings will avoid, including the lack secondary containment, adequate protection for the occasional subzero days as recently experienced and a “rain tax” imposed by our municipal water ordinance. Corncrib housing currently supports breeding groups of up to 10 rhesus macaques in typical harem configuration with 1 male per corncrib. Use of larger runs as proposed, will enable the expansion of >1500 macaque breeders on site, maximizing utilization of proven breeder males. With over 8,500 nonhuman primates on site, NIRC is the largest primate facility in the US, and while not directly supported by NIH, has a rapidly expanding research program and readily available space for expansion, we submit that NIRC is an ideal site for expansion of macaque breeding in support of NIH research.