“Renovation of Building 29 laboratories at the New Iberia Research Center"

– 翻新新伊比利亚研究中心的 29 栋实验室”

• 批准号: 10547926
• 负责人: Francois J Villinger
• 金额: $ 200万
• 依托单位: UNIVERSITY OF LOUISIANA AT LAFAYETTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-19 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10547926
• 关键词: AIDS/HIV problem; African Green Monkey; Animals; Antibodies; Asbestos; Breeding; COVID-19; COVID-19 pandemic; Caring; Clinical; Colorectal; Communicable Diseases; Drug Kinetics; Ensure; Equipment; Excision; Expenditure; Floor; Funding; Growth; HIV; Housing; Institution; Laboratories; Laboratory Research; Louisiana; Macaca; Macaca fascicularis; Macaca mulatta; Macaca nemestrina; Metabolic Diseases; Modeling; Monitor; Monkeys; Mucous Membrane; National Institute of Allergy and Infectious Disease; PET/CT scan; Pathogenesis; Preparation; Research; Research Support; Resources; Rodent; Scientist; Site; Testing; Therapeutic; Universities; Vaccines; Vagina; Viral; X-Ray Computed Tomography; biosafety level 3 facility; building renovation; coronavirus disease; experimental study; fight against; higher education; imaging capabilities; interest; microbicide; nonhuman primate; pandemic disease; prevent; programs; single cell analysis; symposium; wasting

The New Iberia Research Center (NIRC) at the University of Louisiana at Lafayette has undergone tremendous growth over the last 6 years adding some 3000 nonhuman primates for a current total of 9400 animals on site, and its research expenditure rose from ~19 to over 70 million between FY2016 and 2021. This expansion has been markedly accelerated during the COVID pandemic in 2 ways: 1) NIRC has supported the testing of no less than 12 COVID vaccines including the Pfizer-BioNTech as well as monitored the distribution and pharmacokinetics of convalescent antibodies via dynamic PET/CT imaging. 2) Owing to fact that many labs were closed across US institutions during 2020, NIRC scientists ensured that ongoing nonhuman primate experiments could be continued to avoid wasting precious resources. The expansion of NIRC’s in house HIV/AIDS research program is currently limited by the lack of additional research laboratory space to house new hires and their teams, with several candidates interested in joining NIRC and the University of Louisiana at Lafayette, which in December 2021 obtained the coveted R1 status by the Carnegie Commission on Institutions of Higher Education. In preparation of such laboratory expansion, NIRC has completed the demolition of the third floor of Building 29 (~9100 sq ft) along with complete and certified asbestos removal. This space will be ideal to house up to 6 research teams in a combination of open shared as well as separate laboratory spaces, complete with offices, cubicles and a conference room. NIRC supports many onsite and collaborative programs on using nonhuman primates on various metabolic and infectious diseases, most notably HIV lentiviral pathogenesis supported by state of the art imaging capabilities including a whole body to single cell analysis approach, therapeutic approaches aimed at curing HIV, and an extensive program to prevent mucosal viral acquisition via protective experimental vaccines, vaginal and colorectal microbicides. In addition, NIRC has been a key contributor to the fight against COVID-19. The latter pandemic has severely depleted the supply of research macaques and NIRC has been expanding its colonies via the breeding and the transfer of new programs such as the NIAID funded SVEU breeding program. In addition to over 6500 Indian origin rhesus macaques, NIRC is breeding and using Mauritian cynomolgus macaques and African green monkeys as well as a few pigtailed macaques. This NHP program is largely supported by a state-of-the-art onsite clinical laboratory, expert veterinary care and equipment. NIRC has also established an expandable rodent vivarium in the support of research and is planning to build a BSL-3 facility complete with laboratories, rodent and monkey housing. The addition of research laboratories at NIRC will markedly enhance the ability of the Center to assemble a critical mass of scientists focused on HIV research, expanding the breath of the research program fully supported by NHP models, and compete for external funding.

路易斯安那大学拉斐特分校的新伊比利亚研究中心（NIRC）经历了巨大的 在过去的6年里，增加了大约3000只非人类灵长类动物，目前现场共有9400只动物， 其研究支出在2016财年至2021财年期间从约1900万美元增加到超过7000万美元。这种扩展 在COVID大流行期间，在两个方面明显加速：1）NIRC支持了不少于 包括辉瑞BioNTech在内的12种以上的COVID疫苗，并监测了分发情况， 通过动态PET/CT成像的恢复期抗体的药代动力学。2)由于许多实验室 在2020年关闭了美国机构，NIRC的科学家确保正在进行的非人类灵长类动物实验 可以避免浪费宝贵的资源。扩大NIRC的内部艾滋病毒/艾滋病研究 该计划目前受到缺乏额外的研究实验室空间来容纳新员工及其 团队，有几个候选人有兴趣加入NIRC和路易斯安那大学拉斐特分校，这在 2021年12月获得卡内基高等教育机构委员会梦寐以求的R1地位。 为了准备进行这种实验室扩建，NIRC已经完成了29号楼三楼的拆除工作。 （~9100平方英尺）沿着与完整和认证的石棉清除。这个空间将是理想的房子多达6 研究团队在开放共享以及独立的实验室空间的组合，与办公室完成， 一间会议室。NIRC支持许多现场和协作程序使用非人类 灵长类动物对各种代谢和感染性疾病的影响，最值得注意的是HIV慢病毒发病机制， 最先进的成像能力，包括从全身到单细胞的分析方法，治疗 旨在治愈艾滋病毒的方法，以及通过保护性免疫预防粘膜病毒获得的广泛计划， 实验疫苗，阴道和结肠直肠杀微生物剂。此外，NIRC一直是 抗击COVID-19。后一种流行病严重耗尽了研究猕猴和NIRC的供应 一直在扩大其殖民地通过育种和转让的新计划，如NIAID资助 SVEU育种计划。除了6500多只印度恒河猴外，NIRC还在繁殖和使用 非洲食蟹猴和非洲绿色猴以及少数猪尾猴。这个NHP 该计划在很大程度上得到了最先进的现场临床实验室，专家兽医护理和设备的支持。 NIRC还建立了一个可扩展的啮齿动物饲养场，以支持研究，并计划建立一个 BSL-3设施，配有实验室、啮齿动物和猴舍。研究实验室的增加， NIRC将显著提高该中心的能力，使其能够集中大量科学家专门研究艾滋病毒 研究，扩大呼吸的研究计划完全支持的NHP模型，并争夺 外部资金。