Auditory Attention in First Episode Psychosis

第一发作精神病中的听觉注意

• 批准号: 10373684
• 负责人: Dean F Salisbury
• 金额: $ 20.28万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-19 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10373684
• 关键词: Affect; Affective; Area; Attention; Attentional deficit; Auditory; Auditory Evoked Potentials; Auditory area; Auditory system; Biological Markers; Bipolar Disorder; Brain; COVID-19; Cognition; Cognitive; Cognitive deficits; Communication; Complex; Coupling; Delusions; Detection; Diagnostic; Disease; Distal; Early identification; Early treatment; Electroencephalography; Esthesia; Event; Event-Related Potentials; Evoked Potentials; Frequencies; Functional disorder; Goals; Hearing; Human; Impairment; Individual; Interview; Knowledge; Loudness; Magnetic Resonance Imaging; Maps; Measurement; Measures; Nature; Neurodevelopmental Disorder; Neuropsychological Tests; Neurosciences; Occupational; Onset of illness; Parietal Lobe; Participant; Pathology; Persons; Phase; Physiology; Play; Population; Prefrontal Cortex; Process; Protocols documentation; Psychopathology; Psychoses; Psychotic Disorders; Reporting; Research; Role; Sample Size; Scalp structure; Schizophrenia; Sensory; Sensory Process; Services; Signal Transduction; Source; Stimulus; Structure; Symptoms; Testing; Training; Voice; Work; affective psychoses; attentional modulation; auditory processing; base; brain morphology; cognitive ability; cognitive disability; cognitive neuroscience; cognitive performance; deviant; executive function; experimental study; first episode psychosis; follow-up; functional disability; functional outcomes; gray matter; help-seeking behavior; high risk; neurophysiology; nonhuman primate; novel; operation; parent grant; relating to nervous system; research study; response; schizophrenia-spectrum disorder; selective attention; sensor; sensory cortex; social; sound

Selective attention, the ability to focus on one percept among others, is one of the first executive functions affected by psychosis. Basic neuroscience work has begun to elucidate the underlying mechanisms of how selective attention, arising in prefrontal cortex, modulates sensory cortex activity via connections with posterior parietal cortex. In terms of physiology, alpha waves (~10 Hz) and gamma waves (~40 Hz) appear to play a central role in the effects of attention, by which sensory activity to to-be-attended events is increased, while sensory activity to to-be-ignored events is decreased. In human cognitive neuroscience research, studies that examine functional connectivity between different areas of the brain on the basis of specific oscillations (rather than at the scalp) are relatively few. The proposed studies will expand our knowledge of how attention increases sensory activity in the human brain, and how these processes go awry in newly emerging psychosis. In human psychopathology research, several emerging threads have changed the way psychosis is understood. First, evidence indicates progressive cognitive and cortical gray matter decline during the early disease course, even prior to the emergence of psychosis. Second, increasing evidence suggests that psychosis not only affects the highest levels of cognition, but that sensory processes are affected as well. What is not known is to what degree these sensory deficits are due to progressive pathology of cortical sensory areas or to progressive pathology of executive control centers in prefrontal cortex and posterior parietal cortex, such that modulation of sensory activity by executive centers is impaired via reduced functional connectivity. Both schizophrenia and affective psychosis are thought to be late neurodevelopmental disorders with progressive worsening. We hypothesize that higher-order operations that require long range communication and synchronization between multiple distal cortical areas and highly complex integrated processing will be affected first. Hence, we suggest selective attention-based modulation of sensory activity will be impaired quite early in disease course. Our primary goals is to examine how attention affects sensory activity in the auditory system as subjects attend or ignore sounds, with an aim towards disentangling sensory and executive contributions to perceptual deficits in early psychosis, determine brain function and brain structure relationships, and to track progressive functional and structural changes proximal to illness onset. We will use combined EEG & MEG reconstructed into individual brain morphology from structural MRI which will allow for highly precise measurement of neural activity within the brain. Subjects will be tested at first psychotic episode and 6 months later to follow any progressive pathology. The purpose of this Supplement is to perform longitudinal retesting on participants and to increase the number of baseline participants to replace the participants lost to the study from the COVID19 shutdown, and to achieve the necessary sample sizes for reliable analyses and sufficient representation of the larger first psychosis population for generalizability.

选择性注意，即专注于一种感知的能力，是最早的执行功能之一 受精神病影响。基础神经科学工作已经开始阐明其潜在机制 选择性注意，产生于前额叶皮层，通过与后额叶皮层的连接调节感觉皮层活动 顶叶皮质。就生理学而言，α波（~10 Hz）和伽马波（~40 Hz）似乎发挥着作用 在注意力的影响中发挥核心作用，通过这种作用，对要参加的事件的感觉活动会增加，而 对被忽视事件的感觉活动减少。在人类认知神经科学研究中，研究表明 根据特定的振荡（而不是 比头皮）相对较少。拟议的研究将扩展我们对注意力如何增加的了解 人脑中的感觉活动，以及这些过程如何在新出现的精神病中出错。在人类 精神病理学研究中，一些新兴的线索改变了人们对精神病的理解方式。第一的， 有证据表明，在疾病早期，认知和皮质灰质逐渐下降，甚至 在精神病出现之前。其次，越来越多的证据表明精神病不仅影响 最高水平的认知，但感觉过程也会受到影响。不知道达到什么程度 这些感觉缺陷是由于皮质感觉区域的进行性病理学或皮层感觉区域的进行性病理学所致。 执行控制中心位于前额皮质和后顶叶皮质，从而调节感觉 执行中心的活动因功能连接的减少而受到损害。精神分裂症和情感障碍 精神病被认为是晚期神经发育障碍，并逐渐恶化。我们假设 需要多个远端之间的长距离通信和同步的高阶操作 皮质区域和高度复杂的综合处理将首先受到影响。因此，我们建议选择性 在病程的早期，基于注意力的感觉活动调节就会受到损害。我们的主要目标 是检查当受试者注意或忽略声音时注意力如何影响听觉系统的感觉活动， 旨在理清早期精神病中感觉和执行知觉缺陷的影响， 确定大脑功能和大脑结构的关系，并跟踪渐进的功能和结构 疾病发作时发生变化。我们将结合脑电图和脑磁图重建个体大脑 结构 MRI 的形态学将允许高度精确地测量大脑内的神经活动 脑。受试者将在第一次精神病发作时接受测试，并在 6 个月后接受测试，以跟踪任何进展性病理情况。 本补充的目的是对参与者进行纵向重新测试并增加参与者的数量 基线参与者的数量，以取代因新冠病毒关闭而失去研究的参与者，并实现 可靠分析所需的样本量和较大的首次精神病的充分代表性 人口的普遍性。

项目成果

Developmental influences on symptom expression in antipsychotic-naïve first-episode psychosis.

• DOI: 10.1017/s0033291720003463
• 发表时间: 2022-07
• 期刊: Psychological medicine
• 影响因子: 6.9
• 作者: Bridgwater M;Bachman P;Tervo-Clemmens B;Haas G;Hayes R;Luna B;Salisbury DF;Jalbrzikowski M
• 通讯作者: Jalbrzikowski M

Is source-resolved magnetoencephalographic mismatch negativity a viable biomarker for early psychosis?

• DOI: 10.1111/ejn.16107
• 发表时间: 2023-08-03
• 期刊: EUROPEAN JOURNAL OF NEUROSCIENCE
• 影响因子: 3.4
• 作者: Lopez-Caballero，Fran;Curtis，Mark;Salisbury，Dean F. F.
• 通讯作者: Salisbury，Dean F. F.

Functional connectivity and gray matter deficits within the auditory attention circuit in first-episode psychosis.

• DOI: 10.3389/fpsyt.2023.1114703
• 发表时间: 2023
• 期刊: FRONTIERS IN PSYCHIATRY
• 影响因子: 4.7
• 作者: Curtis, Mark T.;Sklar, Alfredo L.;Coffman, Brian A.;Salisbury, Dean F.
• 通讯作者: Salisbury, Dean F.

Recovery of auditory evoked response attentional gain modulation following the first psychotic episode indexes improvements in symptom severity.

• DOI: 10.1002/hbm.26306
• 发表时间: 2023-06-15
• 期刊: HUMAN BRAIN MAPPING
• 影响因子: 4.8
• 作者: Coffman, Brian A.;Curtis, Mark T.;Sklar, Alfredo;Seebold, Dylan;Salisbury, Dean F.
• 通讯作者: Salisbury, Dean F.

Diminished Auditory Cortex Dynamic Range and its Clinical Correlates in First Episode Psychosis.

首发精神病中听觉皮层动态范围的减少及其临床相关性。

• DOI: 10.1093/schbul/sbac208
• 发表时间: 2023
• 期刊: Schizophrenia bulletin
• 影响因子: 6.6
• 作者: Sklar,AlfredoL;Ren,Xi;Chlpka,Lydia;Curtis,Mark;Coffman,BrianA;Salisbury,DeanF
• 通讯作者: Salisbury,DeanF