Real time biofeedback Tai Chi training for knee osteoarthritis: A feasibility study

实时生物反馈太极拳训练治疗膝骨关节炎：可行性研究

• 批准号: 10374319
• 负责人: Wei Liu
• 金额: $ 16.48万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10374319
• 关键词: Aerobic; Affect; Area; Articular Range of Motion; Award; Biofeedback; Biofeedback Training; Biomechanics; Calibration; Cardiovascular Physiology; Chronic; Clinical; Clinical Investigator; Clinical Trials Design; Collaborations; Complementary Health; Complementary and alternative medicine; Data; Degenerative polyarthritis; Development; Diagnostic radiologic examination; Disease Progression; Doctor of Philosophy; Educational Intervention; Effectiveness; Equilibrium; Exercise; Exercise Test; Feasibility Studies; Future; Goals; Grant; Health; Impairment; Individual; Integrative Medicine; Intervention; Joint Instability; K-Series Research Career Programs; Knee; Knee Osteoarthritis; Knee joint; Knowledge; Learning; Measures; Mechanics; Medial; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Mind-Body Intervention; Mission; Movement; Muscle Weakness; Outcome; Pain; Patients; Performance; Pilot Projects; Population; Positioning Attribute; Principal Investigator; Publishing; Rehabilitation therapy; Research; Research Personnel; Research Training; Rheumatology; Risk; Series; Severity of illness; Speed; Statistical Data Interpretation; Strategic Planning; Tai Ji; Technology; Testing; Therapeutic Intervention; Time; Torque; Training; Training Programs; Variant; Walking; Western Ontario and McMaster Universities Arthritis Index; Work; acceptability and feasibility; base; behavioral clinical trial; career; chronic pain; compliance behavior; design; disability; exercise intervention; experience; experimental analysis; functional improvement; improved; insight; joint loading; knee pain; mechanical load; muscle strength; novel; osteoarthritis pain; pain reduction; pain symptom; patient oriented research; pilot trial; programs; public health relevance; recruit; reduced muscle strength; response; therapy development

Program Director/Principal Investigator (Liu, Wei): Abstract The overall goal of this mentored career development award (K23) is to support Wei Liu, PhD to become an independent investigator in the field of complementary and alternative medicine (CAM) and chronic pain, with a focus on biofeedback Tai Chi intervention development and testing. Disabilities that arise from typical impairments of knee osteoarthritis (OA) include decreased muscle strength, reduced range of motion, and decreased aerobic cardiovascular function. A large number of individuals with knee OA experience disability and require rehabilitation. Traditional Tai Chi intervention (TC) has been promising therapeutic intervention for pain reduction in knee OA, but the efficacy of TC as a knee OA intervention have proven inconclusive because individual with knee OA performed TC with widely varying mechanical knee joint loads, this variation could be a confounding factor in any study of TC. Therefore, Dr. Liu proposes a feasibility study in Aim 1 to quantify external knee adduction moment (EKAM), a strong predictor of OA disease severity and progression during TC practice, and in Aim 2, he will introduce real time biofeedback Tai Chi training (BTC) and see if it is feasible to use biofeedback of torque acting on the knee to modify some TC forms by reducing EKAM. In Aim 3, he will conduct a pilot study to determine the feasibility of using optimized BTC training for OA knee pain reduction. The proposed research represents the first study to identify the biomechanical mechanisms of TC exercise (Aim 1 and 2) and target EKAM by using real-time biofeedback approach and manipulate EKAM independently for TC intervention (Aim 3). We can alter medial knee joint loading response of TC. EKAM would be a biomechanical marker for TC intervention associated with clinical outcomes in knee OA. At the completion of the pilot trial in Aim 3, the optimized BTC intervention will be ready to be tested in an R33 to evaluate its efficacy. This proposal represents a 5-year comprehensive mentoring, training and research plan to transition the candidate, Dr. Liu, to a career as a successful independent investigator. By end of the award period, Dr. Liu will have contributed substantially to the field of CAM research. Already an expert on biomechanical approaches to Tai Chi, he will be positioned to become a leader in developing and testing novel CAM interventions in this area, including conducting behavioural clinical trials. OMB No. 0925-0001/0002 (Rev. 03/16 Approved Through 10/31/2018) Page Continuation Format Page

计划总监/首席研究员（LIU，WEI）： 抽象的 这个指导职业发展奖（K23）的总体目标是支持Wei Liu，PhD成为一名 互补和替代医学（CAM）和慢性疼痛领域的独立研究者 专注于生物反馈太极干预开发和测试。典型的残疾 膝盖骨关节炎（OA）的损害包括肌肉力量降低，运动范围减少和 有氧心血管功能降低。大量患有膝盖OA经历残疾的人 并需要康复。传统的太极干预（TC）一直有希望的治疗干预措施 膝盖OA的疼痛减轻，但是TC作为膝盖OA干预的功效已被证明尚无定论 具有膝盖OA的个体进行了TC，其机械膝关节负荷差异很大，这种变化可能是 任何TC研究中的混杂因素。因此，刘博士提出了AIM 1的可行性研究以量化 外部膝盖内收矩（EKAM），这是OA疾病严重程度和TC过程中进展的有力预测指标 练习，在AIM 2中，他将引入实时生物反馈太极拳培训（BTC），看看它是否可行 使用在膝盖上作用的扭矩的生物反馈通过减少Ekam来修改某些TC形式。在AIM 3中，他将 进行试点研究，以确定使用优化的BTC训练减轻膝关节疼痛的可行性。 拟议的研究代表了第一个识别TC运动生物力学机制的研究 （AIM 1和2）和通过实时生物反馈方法并独立操纵Ekam的目标EKAM 用于TC干预（AIM 3）。我们可以改变TC的内侧膝关节负荷响应。 Ekam将是 与膝关节OA中临床结果相关的TC干预的生物力学标记。完成 在AIM 3中的试点试验，优化的BTC干预将准备在R33中进行测试以评估其 功效。该建议代表了一个为期5年的全面指导，培训和研究计划，以过渡 候选人Liu博士从事成功的独立调查员的职业。在颁奖期结束时，博士 刘将为CAM研究领域做出了重大贡献。已经是生物力学专家 泰思（Tai Chi）的方法，他将被定位为开发和测试小说CAM的领导者 该领域的干预措施，包括进行行为临床试验。 OMB编号0925-0001/0002（Rev. 03/16批准通过10/31/2018）页面延续格式页面