Real time biofeedback Tai Chi training for knee osteoarthritis: A feasibility study

实时生物反馈太极拳训练治疗膝骨关节炎：可行性研究

• 批准号: 9761465
• 负责人: Wei Liu
• 金额: $ 16.48万
• 依托单位: VIRGINIA COLLEGE OF OSTEOPATHIC MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9761465
• 关键词: Aerobic; Affect; Area; Articular Range of Motion; Award; Biofeedback; Biofeedback Training; Biomechanics; Calibration; Cardiovascular Physiology; Chronic; Clinical; Clinical Investigator; Clinical Trials Design; Collaborations; Complementary Health; Complementary and alternative medicine; Data; Degenerative polyarthritis; Development; Diagnostic radiologic examination; Disease Progression; Doctor of Philosophy; Educational Intervention; Effectiveness; Equilibrium; Exercise; Exercise stress test; Feasibility Studies; Future; Goals; Grant; Health; Impairment; Individual; Integrative Medicine; Intervention; Joint Instability; K-Series Research Career Programs; Knee; Knee Osteoarthritis; Knee joint; Knowledge; Learning; Measures; Mechanics; Medial; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Mind-Body Intervention; Mission; Movement; Muscle Weakness; Outcome; Pain; Patients; Performance; Pilot Projects; Population; Positioning Attribute; Principal Investigator; Publishing; Rehabilitation therapy; Research; Research Personnel; Research Training; Rheumatology; Risk; Series; Severity of illness; Speed; Statistical Data Interpretation; Strategic Planning; Tai Ji; Technology; Testing; Therapeutic Intervention; Time; Torque; Training; Training Programs; Variant; Walking; Western Ontario and McMaster Universities Arthritis Index; Work; base; behavioral clinical trial; career; chronic pain; compliance behavior; design; disability; exercise intervention; experience; experimental analysis; functional improvement; improved; insight; joint loading; knee pain; mechanical load; muscle strength; novel; osteoarthritis pain; pain reduction; pain symptom; patient oriented research; pilot trial; programs; public health relevance; recruit; reduced muscle strength; response; therapy development

Program Director/Principal Investigator (Liu, Wei): Abstract The overall goal of this mentored career development award (K23) is to support Wei Liu, PhD to become an independent investigator in the field of complementary and alternative medicine (CAM) and chronic pain, with a focus on biofeedback Tai Chi intervention development and testing. Disabilities that arise from typical impairments of knee osteoarthritis (OA) include decreased muscle strength, reduced range of motion, and decreased aerobic cardiovascular function. A large number of individuals with knee OA experience disability and require rehabilitation. Traditional Tai Chi intervention (TC) has been promising therapeutic intervention for pain reduction in knee OA, but the efficacy of TC as a knee OA intervention have proven inconclusive because individual with knee OA performed TC with widely varying mechanical knee joint loads, this variation could be a confounding factor in any study of TC. Therefore, Dr. Liu proposes a feasibility study in Aim 1 to quantify external knee adduction moment (EKAM), a strong predictor of OA disease severity and progression during TC practice, and in Aim 2, he will introduce real time biofeedback Tai Chi training (BTC) and see if it is feasible to use biofeedback of torque acting on the knee to modify some TC forms by reducing EKAM. In Aim 3, he will conduct a pilot study to determine the feasibility of using optimized BTC training for OA knee pain reduction. The proposed research represents the first study to identify the biomechanical mechanisms of TC exercise (Aim 1 and 2) and target EKAM by using real-time biofeedback approach and manipulate EKAM independently for TC intervention (Aim 3). We can alter medial knee joint loading response of TC. EKAM would be a biomechanical marker for TC intervention associated with clinical outcomes in knee OA. At the completion of the pilot trial in Aim 3, the optimized BTC intervention will be ready to be tested in an R33 to evaluate its efficacy. This proposal represents a 5-year comprehensive mentoring, training and research plan to transition the candidate, Dr. Liu, to a career as a successful independent investigator. By end of the award period, Dr. Liu will have contributed substantially to the field of CAM research. Already an expert on biomechanical approaches to Tai Chi, he will be positioned to become a leader in developing and testing novel CAM interventions in this area, including conducting behavioural clinical trials. OMB No. 0925-0001/0002 (Rev. 03/16 Approved Through 10/31/2018) Page Continuation Format Page

项目主任/首席研究员（刘伟）： 抽象的 该导师职业发展奖（K23）的总体目标是支持刘伟博士成为一名 补充和替代医学 (CAM) 和慢性疼痛领域的独立研究者， 专注于生物反馈太极干预的开发和测试。典型的残疾 膝骨关节炎 (OA) 的损伤包括肌肉力量下降、运动范围缩小以及 有氧心血管功能下降。许多膝关节骨关节炎患者出现残疾 并需要康复治疗。传统太极拳干预（TC）一直是一种有前景的治疗干预方法 膝关节 OA 疼痛减轻，但 TC 作为膝关节 OA 干预措施的功效已被证明尚无定论，因为 患有膝 OA 的个体在机械膝关节负荷差异很大的情况下进行 TC，这种变化可能是 任何 TC 研究中的混杂因素。因此，刘博士在目标1中提出了一项可行性研究来量化 膝外收力矩 (EKAM)，TC 期间 OA 疾病严重程度和进展的有力预测因子 练习，在目标2中，他将引入实时生物反馈太极训练（BTC），看看是否可行 使用作用于膝盖的扭矩生物反馈通过减少 EKAM 来修改某些 TC 形式。在目标 3 中，他将 进行一项试点研究，以确定使用优化的 BTC 训练来减轻 OA 膝关节疼痛的可行性。 拟议的研究代表了第一项确定 TC 运动生物力学机制的研究 （目标 1 和 2）通过使用实时生物反馈方法瞄准 EKAM 并独立操纵 EKAM TC 干预（目标 3）。我们可以改变 TC 的内侧膝关节负荷反应。 EKAM 将是 TC 干预的生物力学标志物与膝关节 OA 的临床结果相关。完成时 在 Aim 3 的试点试验中，优化后的 BTC 干预措施将准备在 R33 中进行测试，以评估其效果 功效。该提案代表了一个为期 5 年的全面指导、培训和研究计划，以实现转型 候选人刘博士将成为一名成功的独立调查员。到奖励期结束时，博士。 刘将为 CAM 研究领域做出重大贡献。已经是生物力学专家 接近太极，他将成为开发和测试新型 CAM 的领导者 该领域的干预措施，包括进行行为临床试验。 OMB 编号 0925-0001/0002（修订版 03/16 已批准至 10/31/2018） 页面延续格式页面