Real time biofeedback Tai Chi training for knee osteoarthritis: A feasibility study

实时生物反馈太极拳训练治疗膝骨关节炎：可行性研究

• 批准号: 10468265
• 负责人: Wei Liu
• 金额: $ 16.48万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10468265
• 关键词: Aerobic; Affect; Area; Articular Range of Motion; Award; Biofeedback; Biofeedback Training; Biomechanics; Calibration; Cardiovascular Physiology; Chronic; Clinical; Clinical Investigator; Clinical Trials Design; Collaborations; Complementary Health; Complementary and alternative medicine; Data; Degenerative polyarthritis; Development; Disease Progression; Doctor of Philosophy; Educational Intervention; Effectiveness; Equilibrium; Exercise Test; Feasibility Studies; Future; Goals; Grant; Health; Impairment; Individual; Integrative Medicine; Intervention; Joint Instability; K-Series Research Career Programs; Knee; Knee Osteoarthritis; Knee joint; Knowledge; Learning; Measures; Mechanics; Medial; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Mind-Body Intervention; Mission; Movement; Muscle Weakness; National Center for Complementary and Integrative Health; Outcome; Pain; Patients; Performance; Persons; Pilot Projects; Population; Positioning Attribute; Principal Investigator; Publishing; Rehabilitation therapy; Research; Research Personnel; Research Training; Rheumatology; Risk; Series; Severity of illness; Speed; Statistical Data Interpretation; Strategic Planning; Tai Ji; Technology; Testing; Therapeutic Intervention; Time; Torque; Training; Training Programs; Variant; Walking; Western Ontario and McMaster Universities Arthritis Index; Work; acceptability and feasibility; base; behavioral clinical trial; career; chronic pain; compliance behavior; design; disability; exercise intervention; experience; experimental analysis; functional improvement; improved; insight; joint loading; knee pain; mechanical load; muscle strength; novel; osteoarthritis pain; pain reduction; pain symptom; patient oriented research; pilot test; pilot trial; programs; public health relevance; radiological imaging; recruit; reduced muscle strength; response; therapy development

Program Director/Principal Investigator (Liu, Wei): Abstract The overall goal of this mentored career development award (K23) is to support Wei Liu, PhD to become an independent investigator in the field of complementary and alternative medicine (CAM) and chronic pain, with a focus on biofeedback Tai Chi intervention development and testing. Disabilities that arise from typical impairments of knee osteoarthritis (OA) include decreased muscle strength, reduced range of motion, and decreased aerobic cardiovascular function. A large number of individuals with knee OA experience disability and require rehabilitation. Traditional Tai Chi intervention (TC) has been promising therapeutic intervention for pain reduction in knee OA, but the efficacy of TC as a knee OA intervention have proven inconclusive because individual with knee OA performed TC with widely varying mechanical knee joint loads, this variation could be a confounding factor in any study of TC. Therefore, Dr. Liu proposes a feasibility study in Aim 1 to quantify external knee adduction moment (EKAM), a strong predictor of OA disease severity and progression during TC practice, and in Aim 2, he will introduce real time biofeedback Tai Chi training (BTC) and see if it is feasible to use biofeedback of torque acting on the knee to modify some TC forms by reducing EKAM. In Aim 3, he will conduct a pilot study to determine the feasibility of using optimized BTC training for OA knee pain reduction. The proposed research represents the first study to identify the biomechanical mechanisms of TC exercise (Aim 1 and 2) and target EKAM by using real-time biofeedback approach and manipulate EKAM independently for TC intervention (Aim 3). We can alter medial knee joint loading response of TC. EKAM would be a biomechanical marker for TC intervention associated with clinical outcomes in knee OA. At the completion of the pilot trial in Aim 3, the optimized BTC intervention will be ready to be tested in an R33 to evaluate its efficacy. This proposal represents a 5-year comprehensive mentoring, training and research plan to transition the candidate, Dr. Liu, to a career as a successful independent investigator. By end of the award period, Dr. Liu will have contributed substantially to the field of CAM research. Already an expert on biomechanical approaches to Tai Chi, he will be positioned to become a leader in developing and testing novel CAM interventions in this area, including conducting behavioural clinical trials. OMB No. 0925-0001/0002 (Rev. 03/16 Approved Through 10/31/2018) Page Continuation Format Page

项目主任/首席研究员（刘伟）：