Real time biofeedback Tai Chi training for knee osteoarthritis: A feasibility study

实时生物反馈太极拳训练治疗膝骨关节炎:可行性研究

基本信息

  • 批准号:
    10468265
  • 负责人:
  • 金额:
    $ 16.48万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-08-15 至 2024-07-31
  • 项目状态:
    已结题

项目摘要

Program Director/Principal Investigator (Liu, Wei): Abstract The overall goal of this mentored career development award (K23) is to support Wei Liu, PhD to become an independent investigator in the field of complementary and alternative medicine (CAM) and chronic pain, with a focus on biofeedback Tai Chi intervention development and testing. Disabilities that arise from typical impairments of knee osteoarthritis (OA) include decreased muscle strength, reduced range of motion, and decreased aerobic cardiovascular function. A large number of individuals with knee OA experience disability and require rehabilitation. Traditional Tai Chi intervention (TC) has been promising therapeutic intervention for pain reduction in knee OA, but the efficacy of TC as a knee OA intervention have proven inconclusive because individual with knee OA performed TC with widely varying mechanical knee joint loads, this variation could be a confounding factor in any study of TC. Therefore, Dr. Liu proposes a feasibility study in Aim 1 to quantify external knee adduction moment (EKAM), a strong predictor of OA disease severity and progression during TC practice, and in Aim 2, he will introduce real time biofeedback Tai Chi training (BTC) and see if it is feasible to use biofeedback of torque acting on the knee to modify some TC forms by reducing EKAM. In Aim 3, he will conduct a pilot study to determine the feasibility of using optimized BTC training for OA knee pain reduction. The proposed research represents the first study to identify the biomechanical mechanisms of TC exercise (Aim 1 and 2) and target EKAM by using real-time biofeedback approach and manipulate EKAM independently for TC intervention (Aim 3). We can alter medial knee joint loading response of TC. EKAM would be a biomechanical marker for TC intervention associated with clinical outcomes in knee OA. At the completion of the pilot trial in Aim 3, the optimized BTC intervention will be ready to be tested in an R33 to evaluate its efficacy. This proposal represents a 5-year comprehensive mentoring, training and research plan to transition the candidate, Dr. Liu, to a career as a successful independent investigator. By end of the award period, Dr. Liu will have contributed substantially to the field of CAM research. Already an expert on biomechanical approaches to Tai Chi, he will be positioned to become a leader in developing and testing novel CAM interventions in this area, including conducting behavioural clinical trials. OMB No. 0925-0001/0002 (Rev. 03/16 Approved Through 10/31/2018) Page Continuation Format Page
项目主任/首席研究员(刘伟):

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Wei Liu其他文献

Porous TiC–TiB2–NiAl composites and effect of NiAl contents on pore structure and microstructure
多孔TiC—TiB2—NiAl复合材料及NiAl含量对孔结构和显微结构的影响
  • DOI:
    10.1179/1743290115y.0000000007
  • 发表时间:
    2015-06
  • 期刊:
  • 影响因子:
    1.4
  • 作者:
    Hongzhi Cui;Xiaojie Song;Wei Liu;Nan Hou
  • 通讯作者:
    Nan Hou

Wei Liu的其他文献

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{{ truncateString('Wei Liu', 18)}}的其他基金

New Strategies for Copper-Catalyzed Cross-Coupling of Alkyl Electrophiles
铜催化烷基亲电试剂交叉偶联的新策略
  • 批准号:
    10650863
  • 财政年份:
    2022
  • 资助金额:
    $ 16.48万
  • 项目类别:
Structural Biology of Dopamine Signaling
多巴胺信号传导的结构生物学
  • 批准号:
    10543124
  • 财政年份:
    2021
  • 资助金额:
    $ 16.48万
  • 项目类别:
Structural Biology of Dopamine Signaling
多巴胺信号传导的结构生物学
  • 批准号:
    10322399
  • 财政年份:
    2021
  • 资助金额:
    $ 16.48万
  • 项目类别:
Structural Biology of Dopamine Signaling
多巴胺信号传导的结构生物学
  • 批准号:
    10570686
  • 财政年份:
    2021
  • 资助金额:
    $ 16.48万
  • 项目类别:
Real time biofeedback Tai Chi training for knee osteoarthritis: A feasibility study
实时生物反馈太极拳训练治疗膝骨关节炎:可行性研究
  • 批准号:
    10374319
  • 财政年份:
    2018
  • 资助金额:
    $ 16.48万
  • 项目类别:
Real time biofeedback Tai Chi training for knee osteoarthritis: A feasibility study
实时生物反馈太极拳训练治疗膝骨关节炎:可行性研究
  • 批准号:
    9976459
  • 财政年份:
    2018
  • 资助金额:
    $ 16.48万
  • 项目类别:
Real time biofeedback Tai Chi training for knee osteoarthritis: A feasibility study
实时生物反馈太极拳训练治疗膝骨关节炎:可行性研究
  • 批准号:
    9761465
  • 财政年份:
    2018
  • 资助金额:
    $ 16.48万
  • 项目类别:
Structure and Function of Dopamine Receptors
多巴胺受体的结构和功能
  • 批准号:
    9317762
  • 财政年份:
    2017
  • 资助金额:
    $ 16.48万
  • 项目类别:
4D Robust Optimization in Intensity-Modulated Proton Therapy
调强质子治疗中的 4D 鲁棒优化
  • 批准号:
    8725494
  • 财政年份:
    2012
  • 资助金额:
    $ 16.48万
  • 项目类别:
4D Robust Optimization in Intensity-Modulated Proton Therapy
调强质子治疗中的 4D 鲁棒优化
  • 批准号:
    8353825
  • 财政年份:
    2012
  • 资助金额:
    $ 16.48万
  • 项目类别:

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