UniProt: A centralized protein sequence and function resource

项目总结/摘要 通用蛋白质资源（UniProt）的使命是通过提供免费的 一个可用、稳定、全面、注释丰富、准确的蛋白质序列知识库 （www.uniprot.org）中找到。UniProt集成、解释和分析来自多个来源的数据， 迄今为止最全面的蛋白质序列和功能注释目录， 从成千上万的出版物中获得的信息， 物种这里提出的活动将增加UniProt在生物医学研究和精确度方面的效用 药 由UniProt提供的专家策划的功能信息被广泛认为具有卓越的质量 并且随着新知识的出现而不断更新。我们的第一个目标将是继续策划 科学文献，以确保UniProt保持最新。我们还将与文本挖掘社区合作， 继续提高管理效率。 整理的记录（50万）由未表征蛋白质的记录（8000万）补充。到 我们将继续开发自动注释系统， 基于特征蛋白的知识注释这些蛋白。 我们的第三个目标是连接和整合来自世界各地的蛋白质数据，使UniProt成为 全球蛋白质信息中心。临床变异数据与代谢组学的整合 蛋白质信息将有助于支持精准医学的多组学方法。 我们的第四个目标描述了资源的生产，以确保我们的数据是免费提供，根据 公平的原则。UniProt是数百种生命科学数据资源的基础。连续 需要开发软件，以确保生命科学基础设施的这一关键组成部分的交付。 UniProt网站每月有数十万科学家使用。最终目标描述了如何 我们将通过用户培训、推广和改进用户体验， 界面，由用户测试驱动。

PROJECT SUMMARY/ABSTRACT The mission of the Universal Protein Resource (UniProt) is to support biomedical research by providing a freely available, stable, comprehensive, richly and accurately annotated protein sequence knowledgebase (www.uniprot.org). UniProt integrates, interprets and standardizes data from a multitude of sources to achieve the most comprehensive catalog of protein sequences and functional annotation available to date, providing information from hundreds of thousands of publications for tens of millions of proteins from tens of thousands of species. The activities proposed here will increase the utility of UniProt for biomedical research and precision medicine. The expert curated functional information provided by UniProt is widely acknowledged to be of exceptional quality and is continuously updated as new knowledge becomes available. Our first aim will be to continue to curate the scientific literature to ensure UniProt remains up to date. We will also work with the text-mining community to continue to improve curation efficiency. The curated records (0.5 million) are complemented by the (80 million) records for uncharacterized proteins. To ensure their usefulness for the community we will continue to develop our automatic annotation systems to annotate these proteins based on the knowledge of characterized proteins. Our third aim is to connect to and integrate protein data from resources around the world to make UniProt the worldwide global hub of protein information. The integration of clinical variation data as well as metabolomics information with proteins will help to support the multi-omics approaches of precision medicine. Our fourth aim describes the production of the resource to ensure that our data is freely available according to the FAIR principles. UniProt forms a foundation for hundreds of life sciences data resources. Continuous software development is needed to ensure delivery of this key component of the life science infrastructure. The UniProt website is used by hundreds of thousands of scientists every month. The final aim describes how we will enable this community to make best use of UniProt, through user training, outreach and improved user interfaces, driven by user testing.