UniProt: A centralized protein sequence and function resource

UniProt：集中的蛋白质序列和功能资源

• 批准号: 10372430
• 负责人: Alex Bateman
• 金额: $ 191.68万
• 依托单位: EUROPEAN MOLECULAR BIOLOGY LABORATORY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-08 至 2021-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10372430
• 关键词: Amino Acid Sequence; Animal Model; Biological Sciences; Biomedical Research; Catalogs; Clinical; Communities; Complement; Data; Data Set; Education and Outreach; Ensure; FAIR principles; Foundations; Genomics; Homo sapiens; Infrastructure; Knowledge; Literature; Mission; Ontology; Production; Proteins; Publications; Records; Research; Resources; Scientist; Source; Testing; Update; Variant; Work; annotation system; base; biomedical resource; data resource; data science resource; data standards; human disease; improved; knowledge base; metabolomics; multiple omics; pathogen; personalized approach; precision medicine; protein function; software development; text searching; web site

PROJECT SUMMARY/ABSTRACT The mission of the Universal Protein Resource (UniProt) is to support biomedical research by providing a freely available, stable, comprehensive, richly and accurately annotated protein sequence knowledgebase (www.uniprot.org). UniProt integrates, interprets and standardizes data from a multitude of sources to achieve the most comprehensive catalog of protein sequences and functional annotation available to date, providing information from hundreds of thousands of publications for tens of millions of proteins from tens of thousands of species. The activities proposed here will increase the utility of UniProt for biomedical research and precision medicine. The expert curated functional information provided by UniProt is widely acknowledged to be of exceptional quality and is continuously updated as new knowledge becomes available. Our first aim will be to continue to curate the scientific literature to ensure UniProt remains up to date. We will also work with the text-mining community to continue to improve curation efficiency. The curated records (0.5 million) are complemented by the (80 million) records for uncharacterized proteins. To ensure their usefulness for the community we will continue to develop our automatic annotation systems to annotate these proteins based on the knowledge of characterized proteins. Our third aim is to connect to and integrate protein data from resources around the world to make UniProt the worldwide global hub of protein information. The integration of clinical variation data as well as metabolomics information with proteins will help to support the multi-omics approaches of precision medicine. Our fourth aim describes the production of the resource to ensure that our data is freely available according to the FAIR principles. UniProt forms a foundation for hundreds of life sciences data resources. Continuous software development is needed to ensure delivery of this key component of the life science infrastructure. The UniProt website is used by hundreds of thousands of scientists every month. The final aim describes how we will enable this community to make best use of UniProt, through user training, outreach and improved user interfaces, driven by user testing.

项目摘要/摘要 全球蛋白质资源(UniProt)的使命是通过提供免费的 可用、稳定、全面、丰富、准确标注的蛋白质序列知识库 (www.uniprot.org)。UniProt集成、解释和标准化来自多个来源的数据，以实现 迄今为止最全面的蛋白质序列和功能注释目录，提供 来自数十万种出版物的信息，涉及数万种蛋白质 物种。这里提出的活动将增加UniProt在生物医学研究和精确度方面的效用 医药。 UniProt提供的专家精选的功能信息被广泛认为具有卓越的质量 并随着新知识的出现而不断更新。我们的首要目标将是继续策划 科学文献，以确保UniProt保持最新。我们还将与文本挖掘社区合作，以 持续提高监管效率。 经过整理的记录(50万份)得到了(8000万份)未鉴定蛋白质记录的补充。至 我们将继续开发我们的自动注解系统，以确保它们对社区的实用性 根据特征蛋白质的知识对这些蛋白质进行注释。 我们的第三个目标是连接和集成来自世界各地资源的蛋白质数据，使UniProt成为 全球蛋白质信息中心。临床变异数据与代谢组学的整合 蛋白质信息将有助于支持精准医学的多组学方法。 我们的第四个目标描述了资源的生产，以确保我们的数据可以根据 公平原则。UniProt是数百种生命科学数据资源的基础。连续式 需要进行软件开发，以确保生命科学基础设施的这一关键组成部分的交付。 UniProt网站每月有数十万名科学家使用。最终目标描述了如何 我们将通过用户培训、推广和改进用户，使这个社区能够最好地利用UniProt 界面，由用户测试驱动。