UniProt - Enhancing functional genomics data access for the Alzheimer's Disease (AD) and dementia-related protein research communities

UniProt - 增强阿尔茨海默病 (AD) 和痴呆相关蛋白质研究社区的功能基因组学数据访问

• 批准号: 10121011
• 负责人: Alex Bateman
• 金额: $ 31.87万
• 依托单位: EUROPEAN MOLECULAR BIOLOGY LABORATORY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-18 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10121011
• 关键词: Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Amino Acid Sequence; Amino Acids; Animal Model; Biomedical Research; ClinVar; Communities; Computer Analysis; Data; Dementia; Derivation procedure; Development; Disease; Educational workshop; Feedback; Funding; Gene Proteins; Genes; Genome; Genomics; Goals; Knowledge; Link; Literature; Maps; Methods; Mining; Mission; Neurobiology; Neurodegenerative Disorders; Ontology; Orthologous Gene; Pharmaceutical Preparations; Play; Positioning Attribute; Proteins; Publications; Publishing; Records; Research; Resources; Role; Series; Services; Source; Standardization; Structure; Text; Training; Transcript; Variant; Work; base; data access; deep learning; functional genomics; genetic variant; genomic data; improved; knowledge base; parent grant; precision medicine; prevent; protein expression; protein function; response; text searching; tool; usability

PROJECT SUMMARY UNIPROT - ENHANCING FUNCTIONAL GENOMICS DATA ACCESS FOR THE ALZHEIMER’S DISEASE (AD) AND DEMENTIA-RELATED PROTEIN RESEARCH COMMUNITIES - SUPPLEMENT REQUEST 2020 The mission of the Universal Protein Resource (UniProt) is to support biomedical research by providing a freely available, stable, comprehensive, richly and accurately annotated protein sequence KnowledgeBase (UniProtKB). Currently, 5.7 million US citizens are living with the effects of Alzheimer’s Disease (AD), which is estimated to rise to 14 million by 2025. A National Plan has been implemented by the US aimed at preventing and effectively treating AD and related dementias by 2025. To support precision medicine based on genomic data, UniProt is tasked with providing a centralized resource that both links the genome to the functional proteins it encodes. It also efficiently identifies, captures and disseminates published information on protein function, facilitating computational analysis. The goal of this supplement is to further enhance the usability and content of the AD pages in the prototypic Disease Portal, in response to feedback obtained at a series of NIA-funded AD workshops. We will enable users access to protein pages for genes associated with the disease that have been identified by several groups active in the field, and make these easily discoverable by use of additional disease ontologies. We will provide graphical views of protein expression data and links to data on orthologous genes/proteins in model organism species. We will use text mining to supplement the results of expert literature curation and determine ways in which the research community can directly contribute to UniProt records.

项目摘要 UNIPROT -增强阿尔茨海默病的功能基因组学数据访问 (AD)与痴呆症有关的蛋白质研究社区-请求答复 2020 通用蛋白质资源（UniProt）的使命是通过提供 免费、稳定、全面、丰富、准确注释的蛋白质序列知识库 （UniProtKB）。目前，570万美国公民患有阿尔茨海默病（AD）， 预计到2025年将增加到1400万。美国实施了一项国家计划， 到2025年预防和有效治疗AD和相关痴呆症。支持精准医疗， 在基因组数据方面，UniProt的任务是提供一个集中的资源，将基因组与 它编码的功能蛋白质。它还有效地识别、获取和传播已发布的信息 对蛋白质功能的研究，促进了计算机分析。 这个补充的目标是进一步增强原型中AD页面的可用性和内容 疾病门户网站，以回应在一系列由国家免疫局资助的AD研讨会上获得的反馈。我们将使 用户可以访问与疾病相关的基因的蛋白质页面，这些基因已经被几个 活跃在该领域的团体，并通过使用额外的疾病本体使这些易于识别。我们 将提供蛋白质表达数据的图形视图，并链接到 模式生物物种。我们将使用文本挖掘来补充专家文献策展的结果， 确定研究社区可以直接为UniProt记录做出贡献的方式。