UniProt: A centralized protein sequence and function resource

UniProt：集中的蛋白质序列和功能资源

• 批准号: 8739769
• 负责人: Alex Bateman
• 金额: $ 465万
• 依托单位: EUROPEAN MOLECULAR BIOLOGY LABORATORY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-18 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8739769
• 关键词: Academia; Affect; Amino Acid Sequence; Area; Base Sequence; Biology; Biomedical Research; Biotechnology; Cells; Commit; Communities; Complement; Computer software; Coupled; Data; Databases; Development; Educational workshop; Ensure; Feedback; Funding; Future; Genes; Genetic Variation; Genomics; Goals; Grant; Growth; Health; Human; Imagery; Individual; Industry; International; Link; Literature; Manuals; Maps; Medical; Medicine; Mission; Ontology; Output; Peptide Sequence Determination; Persons; Pharmacologic Substance; Preventive; Proteins; Proteome; Proteomics; Provider; Publishing; Research; Research Infrastructure; Research Personnel; Resources; Science; Services; Solutions; Source; System; Targeted Research; Technology; Testing; Training; Update; Variant; Work; Writing; base; drug discovery; experience; improved; interest; knowledge base; meetings; model organisms databases; novel strategies; online tutorial; outreach; protein function; research and development; social; symposium; transcriptome sequencing; web services; web site

DESCRIPTION (provided by applicant): The long-term objective of the UniProt Consortium is to provide a centralized curated, accurate, stable, and comprehensive protein sequence and function resource by enhancing the UniProt Knowledgebase (UniProtKB) and ensuring that the diverse information in UniProt will be of use to a broad scientific user community by exploiting a range of dissemination strategies. This objective will enable new scientific discoveries in the fields of biomedical research that will enhance human health. The specific aims of the project are: 1. To provide the experimental information associated with proteins through manual curation of the scientific literature. This will be achieved by identifying and curating newly experimentally characterized proteins and by updating existing proteins for new information. Interaction with other manually curated resources will be extended, and community standard interfaces used. 2. To automatically annotate experimentally uncharacterized proteins, increasing both coverage and depth. This will enhance the value of the exponentially growing protein sequence space and allow for the correction of erroneous information. UniProt's rule based system will be made available to the community. 3. To act as the global central hub for protein information. This will be achieved by leveraging data from other resources either as imports or as links/visualization and organizing the data for its optimum use and navigation. New data types will be included as they become available, and the technical infrastructure will be developed to scale with the continued growth in protein sequences. 4. To maintain and further develop UniProt's website and other services. This will be done by creating or incorporating specialized visualizations from other resources for a more intuitive and better overview, and by providing appropriate web services and formats to facilitate the extraction of UniProt's rich data. 5. To actively seek user feedback from and provide training for existing and new user communities. Designated user experience testing and the engagement of new user communities will help to define future directions. Target research communities include researchers working on genetic variation, medical researchers and clinicians, cell biologists and drug discovery/ pharmaceutical researchers. RELEVANCE: The databases produced by the UniProt Consortium provide researchers with an integrated access to protein sequence and function by gathering and enriching data from genomics and proteomics projects as well as the results published by individual researchers. This is a crucial step in making genomics and proteomics research results easily accessible to support biomedical research in academia and industry and hence facilitate the development of preventive and curative strategies for human health.

描述（由申请人提供）：UniProt联盟的长期目标是通过增强UniProt知识库（UniProtKB）并确保UniProt中的多样化信息通过利用一系列传播策略对广泛的科学用户社区有用，从而提供集中策划的、准确的、稳定的和全面的蛋白质序列和功能资源。这一目标将促成生物医学研究领域的新科学发现，增进人类健康。该项目的具体目标是：1。通过人工整理科学文献，提供与蛋白质相关的实验信息。这将通过识别和管理新的实验表征的蛋白质以及更新现有蛋白质以获得新信息来实现。将扩展与其他手动管理资源的交互，并使用社区标准界面。2.自动注释实验未表征的蛋白质，增加覆盖范围和深度。这将提高指数增长的蛋白质序列空间的价值，并允许纠正错误信息。UniProt的基于规则的系统将向社区开放。3.作为蛋白质信息的全球中心枢纽。这将通过以下方式实现：利用来自其他资源的数据，将其作为进口数据或链接/可视化数据，并对数据进行组织，以实现最佳使用和导航。新的数据类型将在可用时被包括在内，技术基础设施将随着蛋白质序列的持续增长而发展。4.维护和进一步发展UniProt的网站和其他服务。这将通过创建或整合来自其他资源的专业可视化来实现，以获得更直观和更好的概述，并通过提供适当的Web服务和格式来促进UniProt丰富数据的提取。5.积极寻求用户反馈，并为现有和新用户社区提供培训。指定的用户体验测试和新用户社区的参与将有助于确定未来的方向。目标研究群体包括从事遗传变异研究的研究人员、医学研究人员和临床医生、细胞生物学家和药物发现/制药研究人员。 相关性：UniProt联盟创建的数据库通过收集和丰富基因组学和蛋白质组学项目的数据以及单个研究人员发表的结果，为研究人员提供了对蛋白质序列和功能的综合访问。这是使基因组学和蛋白质组学研究成果易于获得的关键一步，以支持学术界和工业界的生物医学研究，从而促进制定人类健康的预防和治疗战略。