Mentoring in Endocrine and Metabolic Abnormalities in HIV and Aging

项目摘要 托德·布朗，医学博士，糖尿病内分泌科医学和内分泌学教授， 约翰斯·霍普金斯大学的新陈代谢学院提交了这份申请，续签他的K24中期职业发展 获奖，以便继续在以患者为导向的研究(POR)中为受训学员提供受保护的时间 艾滋病毒内分泌学。布朗博士是世界上为数不多的专门研究内分泌和 艾滋病毒携带者的代谢紊乱。他将继续接受额外的培训，以扩大他的研究计划 以支持更广泛的美国和海外早期调查人员。候选人：布朗博士是一位非常优秀的医生 艾滋病毒合并症领域富有成效的临床研究人员。自2004年以来，他一直得到美国国立卫生研究院的资助 探讨内分泌代谢病的流行病学、发病机制和临床治疗。 HIV感染者的功能障碍，使用NIH支持的长期基础设施作为HIS的平台 调查，包括MACS WIHS联合队列研究(MWCCS)，艾滋病与 静脉注射经验(活的)队列，和艾滋病临床试验小组。以他不同寻常的技能和 在艾滋病毒的内分泌和代谢并发症方面有很强的POR计划，他一直是热门的合作者 在约翰·霍普金斯大学和全国各地的机构担任导师。指导计划/环境：此 应用程序将利用约翰霍普金斯大学广泛的培训资源，包括艾滋病中心 研究，临床和转化研究所，以及K12/T32培训赠款，在各种 特色菜。它利用MWCCS无与伦比的资源和其他资助的研究作为 为多个层次的POR学员提供平台。研究计划：本次K24奖项支持的小说研究 将对理解内分泌和营养不良的原因和后果做出重大贡献 HIV感染者在三个主要领域的代谢异常：1)骨质疏松和骨折风险，2) 性腺功能减退，以及3)胰岛素抵抗。它将在MWCCS正在进行的工作的基础上，探索新的 假设，并扩大受训人员的机会。

Project Summary Todd Brown, MD, PhD, a Professor of Medicine and Endocrinology in the Division of Endocrinology, Diabetes, & Metabolism at Johns Hopkins University, submits this application to renew his K24 Mid-Career Development award in order to continue to provide protected time to mentor trainees in patient-oriented research (POR) in HIV Endocrinology. Dr. Brown is one of the few endocrinologists worldwide specializing in endocrine and metabolic disorders in people living with HIV. He will pursue additional training to expand his research program to support a wider range of early investigators in both the US and abroad. Candidate: Dr. Brown is a highly productive clinical researcher in the HIV Comorbidities field. Since 2004, he has been continuously NIH-funded to investigate the epidemiology, pathogenesis, and clinical management of endocrine and metabolic dysfunction in individuals with HIV, using long-standing, NIH-supported infrastructure as a platform for his investigations, including the MACS WIHS Combined Cohort Study (MWCCS), the AIDS Linked to the IntraVenous Experience (ALIVE) cohort, and the AIDS Clinical Trials Group. With his uncommon skill set and strong POR program in endocrine and metabolic complications in HIV, he has been a sought-after collaborator and mentor at Johns Hopkins and at institutions from around the country. Mentoring Plan/Environment: This application will leverage the extensive training resources at Johns Hopkins, including the Center for AIDS Research, the Institute for Clinical and Translational Research, and K12/T32 training grants in a variety of specialties. It draws on the unparalleled resources of the MWCCS and other funded studies to serve as a platform for POR trainees at multiple levels. Research Plan: The novel research supported by this K24 award will make a significant contribution to the understanding of the causes and consequences of endocrine and metabolic abnormalities in HIV-infected persons in three major areas: 1) Osteoporosis and Fracture Risk, 2) Hypogonadism, and 3) Insulin Resistance. It will build on ongoing work in the MWCCS, explore new hypotheses, and expand opportunities for trainees.