Mentoring in Endocrine and Metabolic Abnormalities in HIV and Aging

艾滋病毒和衰老的内分泌和代谢异常的指导

• 批准号: 10667521
• 负责人: TODD T BROWN
• 金额: $ 19.26万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667521
• 关键词: AIDS clinical trial group; Acquired Immunodeficiency Syndrome; Address; Aging; Area; Award; Benefits and Risks; Bone Density; Cardiac; Cardiology; Cardiovascular Diseases; Clinical; Clinical Management; Clinical Research; Cohort Studies; Communicable Diseases; Consequences of HIV; Coronary Arteriosclerosis; Country; Data; Diabetes Mellitus; Discipline; Disease; Doctor of Philosophy; Endocrine; Endocrine System Diseases; Endocrinologist; Endocrinology; Environment; Epidemiologist; Epidemiology; Faculty; Fracture; Functional disorder; Funding; General Population; Geriatrics; Goals; Grant; HIV; HIV/HCV; Hand Strength; Health; Hepatitis C; High Prevalence; Hypogonadism; Immunoglobulin G; Individual; Inflammation; Inflammatory; Infrastructure; Institution; Insulin Resistance; Internal Medicine; International; Intravenous; Investigation; K-Series Research Career Programs; Link; Medicine; Mentored Clinical Scientist Development Program; Mentors; Mentorship; Metabolic; Metabolic Diseases; Metabolic dysfunction; Metabolism; Mid-Career Clinical Scientist Award (K24); Morphology; Organ; Osteoporosis; Outcome; Pathogenesis; Pattern; Peer Review; Persons; Physical Function; Plasma Proteins; Play; Polysaccharides; Population; Prevention strategy; Productivity; Publications; Quality of life; Research; Research Personnel; Research Support; Resources; Risk; Risk Factors; Role; Science; Secondary Prevention; Series; Testing; Testosterone; The Multicenter AIDS Cohort Study; Time; Training; Translational Research; United States National Institutes of Health; Universities; Woman; Women' s Interagency HIV Study; Work; career development; cohort; comorbidity; experience; fracture risk; fragility fracture; glycosylation; health related quality of life; high risk; interest; medical specialties; member; men; multidisciplinary; next generation; novel; older men; patient oriented research; professor; programs; skills; systemic inflammatory response; testosterone replacement therapy; translational pipeline; walking speed

Project Summary Todd Brown, MD, PhD, a Professor of Medicine and Endocrinology in the Division of Endocrinology, Diabetes, & Metabolism at Johns Hopkins University, submits this application to renew his K24 Mid-Career Development award in order to continue to provide protected time to mentor trainees in patient-oriented research (POR) in HIV Endocrinology. Dr. Brown is one of the few endocrinologists worldwide specializing in endocrine and metabolic disorders in people living with HIV. He will pursue additional training to expand his research program to support a wider range of early investigators in both the US and abroad. Candidate: Dr. Brown is a highly productive clinical researcher in the HIV Comorbidities field. Since 2004, he has been continuously NIH-funded to investigate the epidemiology, pathogenesis, and clinical management of endocrine and metabolic dysfunction in individuals with HIV, using long-standing, NIH-supported infrastructure as a platform for his investigations, including the MACS WIHS Combined Cohort Study (MWCCS), the AIDS Linked to the IntraVenous Experience (ALIVE) cohort, and the AIDS Clinical Trials Group. With his uncommon skill set and strong POR program in endocrine and metabolic complications in HIV, he has been a sought-after collaborator and mentor at Johns Hopkins and at institutions from around the country. Mentoring Plan/Environment: This application will leverage the extensive training resources at Johns Hopkins, including the Center for AIDS Research, the Institute for Clinical and Translational Research, and K12/T32 training grants in a variety of specialties. It draws on the unparalleled resources of the MWCCS and other funded studies to serve as a platform for POR trainees at multiple levels. Research Plan: The novel research supported by this K24 award will make a significant contribution to the understanding of the causes and consequences of endocrine and metabolic abnormalities in HIV-infected persons in three major areas: 1) Osteoporosis and Fracture Risk, 2) Hypogonadism, and 3) Insulin Resistance. It will build on ongoing work in the MWCCS, explore new hypotheses, and expand opportunities for trainees.

项目摘要 托德布朗，医学博士，博士，医学和内分泌学教授，内分泌科，糖尿病， 约翰霍普金斯大学的代谢，提交此申请以更新他的K24中期职业发展 奖励，以继续提供保护的时间，指导学员在以病人为导向的研究（POR）， HIV内分泌学。布朗博士是世界上为数不多的专门从事内分泌和 艾滋病毒感染者的代谢紊乱。他将继续接受额外的培训，以扩大他的研究计划 支持美国和国外更广泛的早期调查人员。候选人：布朗博士是一位 艾滋病合并症领域卓有成效的临床研究者。自2004年以来，他一直受到NIH的资助， 研究内分泌和代谢疾病的流行病学、发病机制和临床管理， 艾滋病毒感染者的功能障碍，使用长期的，NIH支持的基础设施作为他的平台， 调查，包括MACS WIHS联合队列研究（MWCCS），艾滋病与 静脉内经验（ALIVE）队列和艾滋病临床试验组。凭借他非凡的技能， 他在HIV内分泌和代谢并发症方面有着强大的POR计划，他一直是一位广受欢迎的合作者 并在约翰霍普金斯和全国各地的机构担任导师。指导计划/环境：此 申请将利用约翰霍普金斯大学广泛的培训资源，包括艾滋病中心 研究，临床和转化研究所，以及K12/T32培训赠款在各种 特产它利用了MWCCS和其他资助研究的无与伦比的资源， 为POR学员提供多层次的平台。研究计划：K24奖支持的新研究 将为了解内分泌疾病的原因和后果做出重大贡献， HIV感染者在三个主要方面的代谢异常：1）骨质疏松和骨折风险，2） 性腺功能减退; 3）胰岛素抵抗。它将在MWCCS正在进行的工作的基础上， 假设，并扩大学员的机会。

项目成果

Association of hepatitis C infection and acute coronary syndrome: A case-control study.

• DOI: 10.1097/md.0000000000026033
• 发表时间: 2021-05-28
• 期刊: Medicine
• 影响因子: 1.6
• 作者: Wu A;Burrowes S;Zisman E;Brown TT;Bagchi S
• 通讯作者: Bagchi S

Intramuscular depot medroxyprogesterone acetate accentuates bone loss associated with tenofovir disoproxil fumarate-containing antiretroviral therapy initiation in young women living with HIV (the BONE: CARE study): a prospective cohort study in Uganda.

• DOI: 10.1016/s2214-109x(22)00080-8
• 发表时间: 2022-05
• 期刊: LANCET GLOBAL HEALTH
• 影响因子: 34.3
• 作者: Matovu, Flavia Kiweewa;Kiwanuka, Noah;Nabwana, Martin;Scholes, Delia;Musoke, Philippa;Fowler, Mary Glenn;Beksinska, Mags E.;Pettifor, John M.;Brown, Todd T.
• 通讯作者: Brown, Todd T.

Prevalence of and risk factors for hypoglycemic symptoms after gastric bypass and sleeve gastrectomy.

• DOI: 10.1002/oby.21042
• 发表时间: 2015-05
• 期刊: OBESITY
• 影响因子: 6.9
• 作者: Lee, Clare J.;Clark, Jeanne M.;Schweitzer, Michael;Magnuson, Thomas;Steele, Kimberley;Koerner, Olivia;Brown, Todd T.
• 通讯作者: Brown, Todd T.

Risk of post-gastric bypass surgery hypoglycemia in nondiabetic individuals: A single center experience.

• DOI: 10.1002/oby.21479
• 发表时间: 2016-06
• 期刊: Obesity (Silver Spring, Md.)
• 作者: Lee CJ;Wood GC;Lazo M;Brown TT;Clark JM;Still C;Benotti P
• 通讯作者: Benotti P

Clinically Indicated Corticosteroids Do Not Affect Bone Turnover During Immune Restoration of Severely Lymphopenic HIV-Infected Patients.

临床表明皮质类固醇不会影响严重淋巴细胞减少性 HIV 感染患者的免疫恢复期间的骨转换。

• DOI: 10.1089/aid.2015.0028
• 发表时间: 2015
• 期刊: AIDS research and human retroviruses
• 影响因子: 1.5
• 作者: Grant,PhilipM;Sheikh,Virginia;DerSimonian,Rebecca;Rupert,Adam;Roby,Gregg;Pau,Alice;Sneller,MichaelC;Rico,Sheryl-Vi;Brown,ToddT;Sereti,Irini
• 通讯作者: Sereti,Irini