Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center

项目总结(出自U01HL146201合作协议) 这项申请是为了更新这项研究，以帮助艾滋病研究努力(SHARE)，它已经 自1984年以来一直是巴尔的摩-华盛顿特区多中心艾滋病队列研究(MACS)的地点。Mac电脑 在巴尔的摩-华盛顿、芝加哥、匹兹堡和洛杉矶建立了网站，最初是为了研究 男男性行为者中HIV感染的自然病史以及后来出现的有效结合 抗逆转录病毒治疗(CART)，治疗HIV感染者的病史，包括长期与 控制艾滋病毒感染和慢性病以及与老龄化相关的并存。以反映这些 改变艾滋病毒研究的优先事项，Share随后进行了登记，以平衡艾滋病毒-和 并更准确地反映艾滋病毒的流行情况。登记的男性每半年进行一次跟踪调查 自1984年或招生以来，a)提供了问卷数据、体检数据、实验室数据(包括 HIV血清状态、T细胞亚群测量和HIV病毒载量测量)以及大量血浆， 血清、冷冻保存的外周血单核细胞和其他标本；这些允许 分享和互委会为了解已治疗和未治疗的艾滋病毒疾病作出重大贡献，以及 与抗逆转录病毒治疗提高存活率相关的合并症。 本申请响应RFA-HL-19-008，旨在扩大共享队列的后续行动 (约640人)，从2019年到2026年，允许Share(和其他Mac站点)与9个站点合并 将妇女机构间艾滋病毒研究(WIHS)纳入一个单一队列，称为MACS-WIHS联合队列 研究(CCS)，这将包括男性和女性。CCS的具体目标是以平行方式概述的 来自CCS假定数据和协调中心(DACC)的申请，以及该中心的10个具体目标 在CCS的DACC应用程序中概述了单一队列；其中包括心血管(CV)， 肺/睡眠(PS)、神经认知(NC)、衰老(AG)、癌症、HIV发病机制(PA)、心理社会(PS)、 健康差距、平台(PL)和职业发展(CD)目标。《临床分享》的具体目标 研究站点(CRS)将：1)在CCS实现这些目标的7个方面发挥主导作用(即CV、PS、AG、 PA、PS、PL和CD)，包括作为超声心动图和睡眠研究的阅读中心；2)到 有助于实现其他3个CCS目标，以及3)执行所有适用的CCS协议和 支持CCS的科学目标。当地关于炎症和体力活动的倡议也将支持 这些目标充分利用了已有的广泛的后续行动和生物标本储存库 可从此队列中获得，并将根据本提案进行扩展，从而能够对我们的 了解和照顾当今艾滋病毒携带者面临的合并症和其他健康问题。

Project Summary (from U01HL146201 cooperative agreement) This application is for the renewal of the Study to Help the AIDS Research Effort (SHARE), which has been the Baltimore-Washington DC site of the Multicenter AIDS Cohort Study (MACS) since 1984. The MACS was established with sites in Baltimore-Washington, Chicago, Pittsburgh, and Los Angeles, initially to study the natural history of HIV infection in men who have sex with men and later, with the advent of effective combination antiretroviral therapy (cART), the treated history of HIV infection, including the relationship between long-term controlled HIV infection and chronic diseases and co-morbidities associated with aging. To reflect these changing priorities in HIV research, SHARE has had subsequent enrollments to balance proportions of HIV- and HIV+ men and to reflect the HIV epidemic more accurately. Men enrolled have been followed semi annually since 1984 or enrollment and have a) provided questionnaire data, physical exam data, laboratory data (including HIV serostatus, T cell subset measurements, and HIV viral load measurements), and a large repository of plasma, serum, cryopreserved peripheral blood mononuclear cells, and other specimens; and these have permitted SHARE and MACS to make major contributions to the understanding of treated and untreated HIV disease, and comorbidities associated with increased survival due to antiretroviral treatment. The present application, in response to RFA-HL-19-008, aims to extend followup of the SHARE cohort (about 640 men) from 2019 to 2026, to allow merger of SHARE (and the other MACS sites) with the nine sites of the Women’s Interagency HIV Study (WIHS) into a single cohort, termed the MACS-WIHS Combined Cohort Study (CCS), that will include both men and women. The specific aims of the CCS are outlined in a parallel application from the putative Data and Coordinating Center (DACC) of the CCS, and the 10 Specific Aims of that single cohort are outlined in the DACC application for the CCS; these include Cardiovascular (CV), Pulmonary/Sleep (PS), Neurocognitive NC), Aging (AG), Cancer, HIV Pathogenesis (PA), Psychosocial (PS), Health Disparities, Platform (PL), and Career Development (CD) Aims. The specific aims of the SHARE Clinical Research Site (CRS) are to: 1) play a leading role in the achievement 7 of these Aims by the CCS (i.e., CV, PS, AG, PA, PS, PL, and CD), including serving as a reading center for echocardiography and sleep studies; 2) to contribute to the achievement of the other 3 CCS aims, and 3) to implement all applicable CCS protocols and support the scientific goals of the CCS. Local initiatives on inflammation and physical activity will also support these aims, which take full advantage of the extensive follow-up and repository of biological specimens already available from this cohort and which will be extended under this proposal, enabling further contributions to our understanding and care of comorbidities and other health issues faced by people living with HIV today.