Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center
MACS/WIHS 联合队列研究 (MACS/WIHS-CCS) 的临床研究中心 - 巴尔的摩/华盛顿特区中心
基本信息
- 批准号:10658086
- 负责人:
- 金额:$ 3.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-04-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:AIDS/HIV problemAcquired Immunodeficiency SyndromeAreaAtherosclerosisBaltimoreBehavioralBloodBlood specimenCD4 Lymphocyte CountCalibrationCardiacCardiomyopathiesCardiovascular DiseasesClinicalClinical ResearchCohort StudiesDataDevelopmentDiabetes MellitusDiseaseEchocardiographyFunctional disorderFundingGeneral PopulationGenerationsGenesGenotypeHIVHIV SeronegativityHIV SeropositivityHeart AbnormalitiesHeart DiseasesHeart RateHeart failureHigh PrevalenceImageImpairmentLeadLeftLeft Ventricular MassLinkMeasurementMeasuresMendelian randomizationMolecularMyocardial dysfunctionNatureOutcomeParticipantPathway interactionsPersonsPharmaceutical PreparationsPharmacotherapyPhenotypePlasmaPopulationPreventiveProtein AnalysisProteinsProteomicsQuantitative Trait LociReportingResearchResearch PersonnelRiskRisk FactorsSamplingSiteSpecimenStructureTechnologyTestingTherapeuticTherapeutic UsesTrainingTranslational ResearchUnited States National Institutes of HealthVentricularViralVisitWomanantiretroviral therapyaptamerclinical research siteclinical riskcohortcomorbiditydrug developmentgene functionhealth disparityhealthy volunteerheart functionheart imaginghigh riskimaging studyimprovedindexingmenmultiple omicsnext generationnovel therapeuticsprotein biomarkersproteomic signaturerecruitrisk predictionsecondary analysissudden cardiac deathtargeted treatmentultrasound
项目摘要
Abstract
Fund Year 2023 OAR Strategic Funds are requested to perform high-throughput proteomic
measurements to investigate the protein signatures of cardiac dysfunction in MWCCS.
Previously collected blood specimens in participants who completed baseline echocardiography
in MACS Visits 67-71 (n=1195) and WIHS Visits 44-50 (n=1655) will be used to measure
proteomics in order to permit discovery of protein markers. Genotypic data in MACS and WIHS
will be leveraged to conduct Mendelian randomization analysis using protein quantitative trait
loci, allowing causal inference and selection of protein targets for pharmacotherapy. This
supplement will support HIV/AIDS research corresponding to the following NIH high-priority
AIDS-designated topics: (1) HIV-associated comorbidities; (2) cross-cutting areas involving
clinical translational research, cardiovascular disease, proteomics, multi-omics, and health
disparities; and (3) training of the next generation of HIV investigators in omics and
comorbidities research.
摘要
2023年基金年要求OAR战略资金进行高通量蛋白质组学
研究MWCCS患者心功能不全的蛋白质特征的测量。
之前采集的完成基线超声心动图的参与者的血液样本
在互委会访问67-71次(n=1195)和WIHS访问44-50次(n=1655)将用于测量
蛋白质组学,以便发现蛋白质标记物。MACS和WIHS中的基因数据
将利用蛋白质数量性状进行孟德尔随机化分析
基因座,允许因果推断和选择药物治疗的蛋白质靶标。这
补充资金将支持与以下国家卫生研究院高度优先事项相对应的艾滋病毒/艾滋病研究
指定的艾滋病专题:(1)与艾滋病毒有关的合并症;(2)涉及
临床转化研究、心血管疾病、蛋白质组学、多组学和健康
差异;以及(3)培训下一代艾滋病毒调查员的组学和
合并症研究。
项目成果
期刊论文数量(30)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Short-term binge drinking, marijuana, and recreational drug use trajectories in a prospective cohort of people living with HIV at the start of COVID-19 mitigation efforts in the United States.
- DOI:10.1016/j.drugalcdep.2021.109233
- 发表时间:2022-02-01
- 期刊:
- 影响因子:4.2
- 作者:Meanley S;Choi SK;Thompson AB;Meyers JL;D'Souza G;Adimora AA;Mimiaga MJ;Kempf MC;Konkle-Parker D;Cohen MH;Teplin LA;Murchison L;Rubin LH;Rubtsova AA;Weiss DJ;Aouizerat B;Friedman MR;Plankey MW;Wilson TE
- 通讯作者:Wilson TE
Long-term trajectories of C-reactive protein among men living with and without HIV infection in the Multicenter AIDS Cohort Study.
- DOI:10.1093/gerona/glab190
- 发表时间:2021-07
- 期刊:
- 影响因子:0
- 作者:N. Wada;E. Breen;W. Post;V. Stosor;B. Macatangay;J. Margolick
- 通讯作者:N. Wada;E. Breen;W. Post;V. Stosor;B. Macatangay;J. Margolick
Does Social Support Predict Depressive Symptoms? A Longitudinal Study of Midlife and Older Men Who Have Sex with Men from the Multicenter AIDS Cohort Study.
- DOI:10.1891/lgbtq-2020-0042
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Henderson ER;Egan JE;Haberlen SA;Detels R;Teplin LA;Friedman MR;Plankey MW;Coulter RWS
- 通讯作者:Coulter RWS
Self-Perception of Aging and Hypertension in a Cohort of Sexual Minority.
- DOI:10.7759/cureus.43127
- 发表时间:2023-08
- 期刊:
- 影响因子:0
- 作者:Jacobsen AP;Polanka BM;Ware D;Haberlen SA;Brennan-Ing M;Meanley S;Okafor CN;Palella FJ;Bolan RK;Friedman MR;Plankey M
- 通讯作者:Plankey M
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{{ truncateString('TODD T BROWN', 18)}}的其他基金
25th International Workshop on Long-term Complications of HIV and SARS-CoV-2
第 25 届艾滋病毒和 SARS-CoV-2 长期并发症国际研讨会
- 批准号:
10828053 - 财政年份:2023
- 资助金额:
$ 3.89万 - 项目类别:
24th International Workshop on Long-term Complications of HIV and SARS-CoV-2
第 24 届艾滋病毒和 SARS-CoV-2 长期并发症国际研讨会
- 批准号:
10548510 - 财政年份:2022
- 资助金额:
$ 3.89万 - 项目类别:
23rd Annual International Workshop on Co-morbidities and Adverse Drug Reactions in HIV
第23届艾滋病毒合并症和药物不良反应年度国际研讨会
- 批准号:
10327072 - 财政年份:2021
- 资助金额:
$ 3.89万 - 项目类别:
22nd International Workshop on Co-Morbidities and Adverse Drug Reactions in HIV
第22届艾滋病毒合并症和药物不良反应国际研讨会
- 批准号:
10082909 - 财政年份:2020
- 资助金额:
$ 3.89万 - 项目类别:
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center
MACS/WIHS 联合队列研究 (MACS/WIHS-CCS) 的临床研究中心 - 巴尔的摩/华盛顿特区中心
- 批准号:
10370339 - 财政年份:2019
- 资助金额:
$ 3.89万 - 项目类别:
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center
MACS/WIHS 联合队列研究 (MACS/WIHS-CCS) 的临床研究中心 - 巴尔的摩/华盛顿特区中心
- 批准号:
10462255 - 财政年份:2019
- 资助金额:
$ 3.89万 - 项目类别:
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center
MACS/WIHS 联合队列研究 (MACS/WIHS-CCS) 的临床研究中心 - 巴尔的摩/华盛顿特区中心
- 批准号:
10220553 - 财政年份:2019
- 资助金额:
$ 3.89万 - 项目类别:
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center
MACS/WIHS 联合队列研究 (MACS/WIHS-CCS) 的临床研究中心 - 巴尔的摩/华盛顿特区中心
- 批准号:
10213917 - 财政年份:2019
- 资助金额:
$ 3.89万 - 项目类别:
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center
MACS/WIHS 联合队列研究 (MACS/WIHS-CCS) 的临床研究中心 - 巴尔的摩/华盛顿特区中心
- 批准号:
9903475 - 财政年份:2019
- 资助金额:
$ 3.89万 - 项目类别:
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center
MACS/WIHS 联合队列研究 (MACS/WIHS-CCS) 的临床研究中心 - 巴尔的摩/华盛顿特区中心
- 批准号:
10223578 - 财政年份:2019
- 资助金额:
$ 3.89万 - 项目类别:
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