Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center

MACS/WIHS 联合队列研究 (MACS/WIHS-CCS) 的临床研究中心 - 巴尔的摩/华盛顿特区中心

• 批准号: 10658086
• 负责人: TODD T BROWN
• 金额: $ 3.89万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10658086
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Area; Atherosclerosis; Baltimore; Behavioral; Blood; Blood specimen; CD4 Lymphocyte Count; Calibration; Cardiac; Cardiomyopathies; Cardiovascular Diseases; Clinical; Clinical Research; Cohort Studies; Data; Development; Diabetes Mellitus; Disease; Echocardiography; Functional disorder; Funding; General Population; Generations; Genes; Genotype; HIV; HIV Seronegativity; HIV Seropositivity; Heart Abnormalities; Heart Diseases; Heart Rate; Heart failure; High Prevalence; Image; Impairment; Lead; Left; Left Ventricular Mass; Link; Measurement; Measures; Mendelian randomization; Molecular; Myocardial dysfunction; Nature; Outcome; Participant; Pathway interactions; Persons; Pharmaceutical Preparations; Pharmacotherapy; Phenotype; Plasma; Population; Preventive; Protein Analysis; Proteins; Proteomics; Quantitative Trait Loci; Reporting; Research; Research Personnel; Risk; Risk Factors; Sampling; Site; Specimen; Structure; Technology; Testing; Therapeutic; Therapeutic Uses; Training; Translational Research; United States National Institutes of Health; Ventricular; Viral; Visit; Woman; antiretroviral therapy; aptamer; clinical research site; clinical risk; cohort; comorbidity; drug development; gene function; health disparity; healthy volunteer; heart function; heart imaging; high risk; imaging study; improved; indexing; men; multiple omics; next generation; novel therapeutics; protein biomarkers; proteomic signature; recruit; risk prediction; secondary analysis; sudden cardiac death; targeted treatment; ultrasound

Abstract Fund Year 2023 OAR Strategic Funds are requested to perform high-throughput proteomic measurements to investigate the protein signatures of cardiac dysfunction in MWCCS. Previously collected blood specimens in participants who completed baseline echocardiography in MACS Visits 67-71 (n=1195) and WIHS Visits 44-50 (n=1655) will be used to measure proteomics in order to permit discovery of protein markers. Genotypic data in MACS and WIHS will be leveraged to conduct Mendelian randomization analysis using protein quantitative trait loci, allowing causal inference and selection of protein targets for pharmacotherapy. This supplement will support HIV/AIDS research corresponding to the following NIH high-priority AIDS-designated topics: (1) HIV-associated comorbidities; (2) cross-cutting areas involving clinical translational research, cardiovascular disease, proteomics, multi-omics, and health disparities; and (3) training of the next generation of HIV investigators in omics and comorbidities research.

摘要 2023年基金年要求OAR战略资金进行高通量蛋白质组学 研究MWCCS患者心功能不全的蛋白质特征的测量。 之前采集的完成基线超声心动图的参与者的血液样本 在互委会访问67-71次(n=1195)和WIHS访问44-50次(n=1655)将用于测量 蛋白质组学，以便发现蛋白质标记物。MACS和WIHS中的基因数据 将利用蛋白质数量性状进行孟德尔随机化分析 基因座，允许因果推断和选择药物治疗的蛋白质靶标。这 补充资金将支持与以下国家卫生研究院高度优先事项相对应的艾滋病毒/艾滋病研究 指定的艾滋病专题：(1)与艾滋病毒有关的合并症；(2)涉及 临床转化研究、心血管疾病、蛋白质组学、多组学和健康 差异；以及(3)培训下一代艾滋病毒调查员的组学和 合并症研究。

项目成果

Short-term binge drinking, marijuana, and recreational drug use trajectories in a prospective cohort of people living with HIV at the start of COVID-19 mitigation efforts in the United States.

• DOI: 10.1016/j.drugalcdep.2021.109233
• 发表时间: 2022-02-01
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Meanley S;Choi SK;Thompson AB;Meyers JL;D'Souza G;Adimora AA;Mimiaga MJ;Kempf MC;Konkle-Parker D;Cohen MH;Teplin LA;Murchison L;Rubin LH;Rubtsova AA;Weiss DJ;Aouizerat B;Friedman MR;Plankey MW;Wilson TE
• 通讯作者: Wilson TE

Long-term trajectories of C-reactive protein among men living with and without HIV infection in the Multicenter AIDS Cohort Study.

• DOI: 10.1093/gerona/glab190
• 发表时间: 2021-07
• 期刊: The journals of gerontology. Series A, Biological sciences and medical sciences
• 作者: N. Wada;E. Breen;W. Post;V. Stosor;B. Macatangay;J. Margolick

CARDIOVASCULAR DISEASE IN HIV.

HIV 中的心血管疾病。

• 发表时间: 2022
• 期刊: Transactions of the American Clinical and Climatological Association
• 作者: Post,WendyS

Early Life Trauma and Social Processing in HIV: The Role of Neuroendocrine Factors and Inflammation.

• DOI: 10.1097/psy.0000000000001124
• 发表时间: 2022-10-01
• 期刊: PSYCHOSOMATIC MEDICINE
• 影响因子: 3.3
• 作者: Rubin, Leah H.;Bhattacharya, Deeya;Fuchs, Joelle;Matthews, Abigail;Abdellah, Sarah;Veenhuis, Rebecca T.;Langenecker, Scott A.;Weber, Kathleen M.;Nazarloo, Hans P.;Keating, Sheila M.;Carter, C. Sue;Maki, Pauline M.
• 通讯作者: Maki, Pauline M.

Does Social Support Predict Depressive Symptoms? A Longitudinal Study of Midlife and Older Men Who Have Sex with Men from the Multicenter AIDS Cohort Study.

• DOI: 10.1891/lgbtq-2020-0042
• 发表时间: 2021
• 期刊: Annals of LGBTQ public and population health
• 作者: Henderson ER;Egan JE;Haberlen SA;Detels R;Teplin LA;Friedman MR;Plankey MW;Coulter RWS
• 通讯作者: Coulter RWS