Social Connectedness in Pediatric Brain Cancer Survivors

儿童脑癌幸存者的社会联系

• 批准号: 10373555
• 负责人: Matthew C. Hocking
• 金额: $ 50.26万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10373555
• 关键词: Address; Adult; Affect; Age; Behavior; Body Composition; Body mass index; Brain; Brain Injuries; Cancer Survivor; Cancer Survivorship; Cerebellar Pilocytic Astrocytoma; Childhood Brain Neoplasm; Childhood Malignant Brain Tumor; Clinical; Cognitive; Craniopharyngioma; Data; Development; Diagnosis; Endocrine; Exhibits; Face Processing; Family; Family health status; Fatigue; Friends; Friendships; Goals; Health; Hearing; Hormones; Impairment; Intervention; Knowledge; Late Effects; Lead; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Childhood Neoplasm; Malignant Neoplasms; Malignant neoplasm of brain; Marriage; Measurement; Measures; Medical; Mental Health; Metabolic; Modeling; Morbidity - disease rate; Neurologic; Neurosecretory Systems; Non-Malignant; Operative Surgical Procedures; Outcome; Participant; Pediatric Hospitals; Personal Satisfaction; Philadelphia; Physical therapy; Pilocytic Astrocytoma; Process; Radiation; Research; Rest; Risk; Risk Factors; Schools; Secondary to; Social Behavior; Social isolation; Somatotropin; Survivors; Testing; Thyroid Gland; Time; Visit; Well in self; Youth; biopsychosocial; cancer therapy; cohort; effective intervention; experience; health related quality of life; improved; information processing; innovation; interest; irradiation; longitudinal design; medulloblastoma; neurobiological mechanism; neuroimaging marker; novel; peer; prospective; recruit; sex; side effect; social; social attention; social factors; social influence; tumor

PROJECT SUMMARY/ABSTRACT Survivors of pediatric brain tumors often experience significant problems with social connectedness during youth that have lasting effects as adults (e.g., reduced rates of marriage). However, the factors contributing to these difficulties are unclear and little is known about how domains of social connectedness influence health- related quality of life (HRQL) and psychological well-being over time in survivors of pediatric brain cancer. Further, intervention efforts to address these issues have been limited by a lack of research on the underlying risk and mechanistic factors of social connectedness. Candidate risk and mechanistic factors include age at diagnosis, treatment, and treatment-related morbidities across many domains (e.g., cognitive, neurologic, endocrine, metabolic). Additionally, brain cancer treatments disrupt neurodevelopmental processes that are essential to social behavior, such as brain connectivity, face processing, and social attention. Establishing the importance of social connectedness to overall health and the mechanistic processes contributing to social connectedness impairments in pediatric brain cancer survivors is important in order to develop appropriate interventions. The broad objectives of this proposal are to compare domains of social connectedness among survivors of malignant brain tumors to survivors of non-malignant brain tumors, evaluate the influence of social connectedness on HQRL and psychological well-being among survivors, and to evaluate risk and mechanistic factors for the trajectory of social connectedness. We propose an innovative study of youth treated for medulloblastoma (MB), cerebellar pilocytic astrocytoma (PA) or craniopharyngioma (CP) (N = 180; ages 8-16) using a 2-year accelerated longitudinal design with annual visits with cohorts stratified by time since diagnosis. Clinical differences between groups (e.g., malignant/non-malignant, use of craniospinal irradiation) allow for tests of their unique impacts on social connectedness and for identification of potential intervention targets. Participants will be recruited from the Children's Hospital of Philadelphia. At each study visit, participants will complete measures of social connectedness, HRQL, and psychological well-being, as well as assessments of body composition, neuroendocrine function, hearing, brain connectivity (e.g., MRI), social information processing (SIP) and social behavior. Neuroimaging markers of interest include structural connectivity, resting state functional connectivity, and functional connectivity in the social brain during social processing tasks. We hypothesize that social connectedness, and thus HRQL and psychological well-being, are uniquely impacted in MB survivors, and that risk (e.g., CSI) and mechanistic factors (e.g., hearing, social behavior) affect social connectedness over time. We expect to establish deficits in social connectedness as a notable late effect in survivors of medulloblastoma with significant impact on HRQL and well-being and to identify mechanisms of social connectedness. By identifying the mechanisms underlying social connectedness, we can then develop interventions that target key mechanistic factors and improve social connectedness, health, and well-being.

项目摘要/摘要 小儿脑肿瘤的幸存者经常在社会联系中遇到重大问题 成年人具有持久影响的年轻人（例如，结婚率降低）。但是，导致的因素 这些困难尚不清楚，关于社会联系领域如何影响健康的知之甚少 - 小儿脑癌幸存者随着时间的流逝，相关的生活质量（HRQL）和心理健康。 此外，由于缺乏对基础的研究而限制了解决这些问题的干预措施 社会联系的风险和机理因素。候选风险和机理因素包括年龄 许多领域的诊断，治疗和与治疗相关的病因（例如，认知，神经系统， 内分泌，代谢）。此外，脑癌治疗破坏了神经发育过程 对社会行为必不可少的，例如大脑连通性，面对处理和社会关注。建立 社会联系与整体健康的重要性以及有助于社会的机械过程 小儿脑癌幸存者中的连接性障碍对于发展适当的 干预措施。该提案的广泛目标是比较之间的社会联系领域 恶性脑肿瘤的幸存者对非恶性脑肿瘤的幸存者，评估社会的影响 幸存者的HQRL和心理健康的联系，并评估风险和机械 社会联系轨迹的因素。我们建议对接受治疗的青年进行创新研究 髓母细胞瘤（MB），小脑毛囊星形胶质细胞瘤（PA）或颅咽瘤（CP）（n = 180; 8-16岁） 使用2年的加速纵向设计，每年访问与诊断以来按时间分层的同类群。 组之间的临床差异（例如，恶性/非恶性，使用颅骨辐射）允许 测试它们对社会联系和识别潜在干预目标的独特影响。 参与者将从费城儿童医院招募。在每次研究访问中，参与者将 完全衡量社会联系，HRQL和心理健康，以及评估 身体成分，神经内分泌功能，听力，大脑连通性（例如MRI），社会信息 处理（SIP）和社会行为。感兴趣的神经影像学标记包括结构连通性，休息 在社会处理任务中，国家功能连通性和社交大脑中的功能连通性。我们 假设社会联系，因此HRQL和心理健康受到了独特的影响 MB幸存者，以及这种风险（例如CSI）和机械因素（例如听力，社会行为）会影响社会 随着时间的推移连接。我们期望在社会联系方面建立赤字，作为明显的后期效果 髓母细胞瘤的幸存者对HRQL和幸福感有重大影响，并确定 社会联系。通过确定社会联系的基本机制，我们可以发展 针对关键机械因素并改善社会联系，健康和福祉的干预措施。