Neurocognitive and Family Functioning at End of Therapy in Pediatric Brain Tumor

小儿脑肿瘤治疗结束时的神经认知和家庭功能

• 批准号: 8541773
• 负责人: Matthew C. Hocking
• 金额: $ 7.87万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-07 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8541773
• 关键词: Affect; Aftercare; Age; Area; Caregivers; Caring; Central Nervous System Diseases; Cephalic; Child; Childhood; Childhood Brain Neoplasm; Data; Disease; Family; Family Caregiver; Future; Goals; Grant; Intervention; Investigation; Late Effects; Literature; Measures; Medical; Memory; Modeling; Neurocognitive; Neurocognitive Deficit; Neuropsychological Tests; Outcome; Parents; Participant; Pathway interactions; Patients; Pediatric Hospitals; Philadelphia; Population; Psychosocial Factor; Psychosocial Influences; Quality of life; Radiation; Recruitment Activity; Research; Short-Term Memory; Spinal; Survivors; System; Time; Traumatic Brain Injury; base; childhood cancer survivor; clinical care; contextual factors; executive function; experience; family influence; family management; functional outcomes; health related quality of life; indexing; memory process; neglect; neuro-oncology; oncology program; processing speed; prospective; psychosocial; public health relevance; social; survivorship; tumor

DESCRIPTION (provided by applicant): Childhood brain tumor survivors experience neurocognitive declines that may impact the family system. Research with other illness populations (e.g., traumatic brain injury) illustrates the potential of neurocognitive functioning and family functioning to affect each other. The primary goals of this application are to examine the concurrent relations between survivor neurocognitive functioning and family functioning (Aim 1) and the prospective influences of family functioning (Aim 2) and medical treatment intensity (Aim 3) on survivor neurocognitive functioning. The proposed research is the first known study to investigate prospectively these interrelations in childhood brain tumor survivors (N = 50) and their caregivers. Participants will include those treated with either cranial or cranial-spinal radiation and transitioning off of active medical treatment. Participants will complete a brief battery of neuropsychological tests assessing all areas where childhood brain tumor survivors generally show deficits (working memory, processing speed, verbal memory and executive function) at the conclusion of medical treatment (T1) and again 6 months later (T2). Caregivers also will complete well-validated measures of quality of life and family functioning at both time points. Twenty-five participants with Time 2 data also will repeat these measures 1 year post-treatment (T3). It is hypothesized that (1 & 2) better family functioning will be positively associated with concurrent survivor neurocognitive functioning and survivor and caregiver quality of life at T2 and (3) better family functioning at T1 will be associated with fewer decline in survivor neurocognitive functioning at T2. It also is hypothesized (4) that greater treatment intensity will be associated with greater decline in survivor neurocognitive functioning. Exploratory analyses will examine whether family functioning at T1 moderates the relation between treatment intensity and decline in neurocognitive functioning seen at T2. Findings from this study could inform clinical care with childhood brain tumor patients and subsequent research among a broader group of survivors affected by central nervous system disease. Data from this study will be used for future grant submissions and will serve as the basis for a programmatic line of research that examines psychosocial influences on the neurocognitive late effects experienced by childhood cancer survivors.

DESCRIPTION (provided by applicant): Childhood brain tumor survivors experience neurocognitive declines that may impact the family system. Research with other illness populations (e.g., traumatic brain injury) illustrates the potential of neurocognitive functioning and family functioning to affect each other. The primary goals of this application are to examine the concurrent relations between survivor neurocognitive functioning and family functioning (Aim 1) and the prospective influences of family functioning (Aim 2) and medical treatment intensity (Aim 3) on survivor neurocognitive functioning. The proposed research is the first known study to investigate prospectively these interrelations in childhood brain tumor survivors (N = 50) and their caregivers. Participants will include those treated with either cranial or cranial-spinal radiation and transitioning off of active medical treatment. Participants will complete a brief battery of neuropsychological tests assessing all areas where childhood brain tumor survivors generally show deficits (working memory, processing speed, verbal memory and executive function) at the conclusion of medical treatment (T1) and again 6 months later (T2). Caregivers also will complete well-validated measures of quality of life and family functioning at both time points. Twenty-five participants with Time 2 data also will repeat these measures 1 year post-treatment (T3). It is hypothesized that (1 & 2) better family functioning will be positively associated with concurrent survivor neurocognitive functioning and survivor and caregiver quality of life at T2 and (3) better family functioning at T1 will be associated with fewer decline in survivor neurocognitive functioning at T2. It also is hypothesized (4) that greater treatment intensity will be associated with greater decline in survivor neurocognitive functioning. Exploratory analyses will examine whether family functioning at T1 moderates the relation between treatment intensity and decline in neurocognitive functioning seen at T2. Findings from this study could inform clinical care with childhood brain tumor patients and subsequent research among a broader group of survivors affected by central nervous system disease. Data from this study will be used for future grant submissions and will serve as the basis for a programmatic line of research that examines psychosocial influences on the neurocognitive late effects experienced by childhood cancer survivors.

项目成果

Development of the Pediatric Neuro-Oncology Rating of Treatment Intensity (PNORTI).

儿科神经肿瘤治疗强度评级 (PNORTI) 的发展。

• DOI: 10.1007/s11060-017-2618-2
• 发表时间: 2018
• 期刊: Journal of neuro-oncology
• 影响因子: 3.9
• 作者: Hocking,MatthewC;Hobbie,Wendy;Fisher,MichaelJ
• 通讯作者: Fisher,MichaelJ