Neurocognitive and Family Functioning at End of Therapy in Pediatric Brain Tumor

小儿脑肿瘤治疗结束时的神经认知和家庭功能

基本信息

批准号：
8541773
负责人：
Matthew C. Hocking
金额：
$ 7.87万
依托单位：
CHILDREN'S HOSP OF PHILADELPHIA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-07 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8541773
关键词：
Affect Aftercare Age Area Caregivers Caring Central Nervous System Diseases Cephalic Child Childhood Childhood Brain Neoplasm Data Disease Family Family Caregiver Future Goals Grant Intervention Investigation Late Effects Literature Measures Medical Memory Modeling Neurocognitive Neurocognitive Deficit Neuropsychological Tests Outcome Parents Participant Pathway interactions Patients Pediatric Hospitals Philadelphia Population Psychosocial Factor Psychosocial Influences Quality of life Radiation Recruitment Activity Research Short-Term Memory Spinal Survivors System Time Traumatic Brain Injury base childhood cancer survivor clinical care contextual factors executive function experience family influence family management functional outcomes health related quality of life indexing memory process neglect neuro-oncology oncology program processing speed prospective psychosocial public health relevance social survivorship tumor

项目摘要

DESCRIPTION (provided by applicant): Childhood brain tumor survivors experience neurocognitive declines that may impact the family system. Research with other illness populations (e.g., traumatic brain injury) illustrates the potential of neurocognitive functioning and family functioning to affect each other. The primary goals of this application are to examine the concurrent relations between survivor neurocognitive functioning and family functioning (Aim 1) and the prospective influences of family functioning (Aim 2) and medical treatment intensity (Aim 3) on survivor neurocognitive functioning. The proposed research is the first known study to investigate prospectively these interrelations in childhood brain tumor survivors (N = 50) and their caregivers. Participants will include those treated with either cranial or cranial-spinal radiation and transitioning off of active medical treatment. Participants will complete a brief battery of neuropsychological tests assessing all areas where childhood brain tumor survivors generally show deficits (working memory, processing speed, verbal memory and executive function) at the conclusion of medical treatment (T1) and again 6 months later (T2). Caregivers also will complete well-validated measures of quality of life and family functioning at both time points. Twenty-five participants with Time 2 data also will repeat these measures 1 year post-treatment (T3). It is hypothesized that (1 & 2) better family functioning will be positively associated with concurrent survivor neurocognitive functioning and survivor and caregiver quality of life at T2 and (3) better family functioning at T1 will be associated with fewer decline in survivor neurocognitive functioning at T2. It also is hypothesized (4) that greater treatment intensity will be associated with greater decline in survivor neurocognitive functioning. Exploratory analyses will examine whether family functioning at T1 moderates the relation between treatment intensity and decline in neurocognitive functioning seen at T2. Findings from this study could inform clinical care with childhood brain tumor patients and subsequent research among a broader group of survivors affected by central nervous system disease. Data from this study will be used for future grant submissions and will serve as the basis for a programmatic line of research that examines psychosocial influences on the neurocognitive late effects experienced by childhood cancer survivors.

描述（由申请人提供）：儿童脑肿瘤幸存者经历了可能影响家庭系统的神经认知下降。与其他疾病人群的研究（例如，创伤性脑损伤）说明了神经认知功能和家庭功能相互影响的潜力。该应用的主要目标是检查幸存者神经认知功能与家庭功能（AIM 1）与家庭功能（AIM 2）和医疗治疗强度（AIM 3）对幸存者神经认知功能的前瞻性影响之间的并发关系。拟议的研究是第一项已知的研究，旨在研究儿童脑肿瘤幸存者（n = 50）及其护理人员的这些相互关系。参与者将包括那些接受颅骨或颅骨辐射治疗的人，并通过主动治疗过渡。参与者将完成一系列简短的神经心理学测试，评估儿童脑肿瘤幸存者在医疗治疗（T1）结束时通常显示出脑肿瘤幸存者通常显示出缺陷（工作记忆，处理速度，言语记忆和执行功能）的所有领域（T1）。护理人员还将在两个时间点完成验证的生活质量和家庭功能的衡量标准。有时间2数据的25名参与者还将在治疗后1年重复这些措施（T3）。假设（1＆2）更好的家庭功能将与同时的幸存者神经认知功能呈正相关，以及T2时的幸存者和照料者的生活质量，以及（3）T1更好的家庭功能将与T2处于T2的幸存者神经认知功能的降低相关。还可以假设（4）更大的治疗强度将与幸存者神经认知功能下降更大有关。探索性分析将检查在T1处的家庭功能是否会在T2处看到的治疗强度与神经认知功能的下降之间的关系。这项研究的发现可以为儿童脑肿瘤患者提供临床护理，并随后在受中枢神经系统疾病影响的一群幸存者中进行研究。这项研究的数据将用于未来的赠款提交，并将作为一项计划研究线的基础，该研究线研究对儿童癌症幸存者所经历的神经认知后期影响进行了社会心理影响。