A Prospective Study of Social Competence in Pediatric Brain Tumor Survivors

儿科脑肿瘤幸存者社交能力的前瞻性研究

基本信息

批准号：
8739626
负责人：
Matthew C. Hocking
金额：
$ 13.07万
依托单位：
CHILDREN'S HOSP OF PHILADELPHIA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-23 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8739626
关键词：
Address Affect Affective Aftercare Age Animal Tarsus Area Attention Award Biological Brain Brain Diseases Brain Neoplasms Brain region Cancer Center Caregivers Central Nervous System Diseases Child Childhood Childhood Brain Neoplasm Clinical Data Collection Development Disease Doctor of Philosophy Exhibits Family Focus Groups Friendships Funding Goals Grant Health Intervention Investigation Journals Knoll brand of cerivastatin sodium Late Effects Malignant Childhood Neoplasm Measures Medical Mentorship Methods Modeling Neuraxis Neurocognitive Outcome Parent-Child Relations Parents Participant Pathway interactions Patients Pediatric Brain Injury Pediatric Hospitals Pediatric Oncology Phase Philadelphia Population Problem Solving Prospective Studies Publications Quality of life Recruitment Activity Research Research Peer Review Research Personnel Risk Sampling Scientific Advances and Accomplishments Secondary to Shapes Short-Term Memory Social Adjustment Social Environment Social Functioning Social Interaction Social Problems Solid Neoplasm Survival Rate Survivors Testing Time Training Training Support Traumatic Brain Injury Treatment Factor Writing base cancer therapy career childhood cancer survivor clinical care cognitive neuroscience design experience family influence functional outcomes health care economics health related quality of life heuristics improved information processing memory process neuro-oncology peer prospective psychologic psychosocial psychosocial adjustment resilience skills social social model social skills survivorship symposium tumor

项目摘要

DESCRIPTION (provided by applicant): Childhood brain tumor survivors experience significant neurocognitive and social deficits secondary to their disease and related medical treatments that contribute to them having the poorest health- related quality of life among childhood cancer survivors. Although children surviving brain tumors have significant social adjustment difficulties (e.g., fewer friendships, less accepted by peers), little research has examined their social competence over time or identified predictors of their social adjustment. Findings from other pediatric brain injury populations (e.g., traumatic brain injury) suggests deficits in social information processing and illustrates the influence of family functioning on social outcomes yet these associations have not been explored in pediatric brain tumor survivors. This proposal would be the first known prospective investigation of survivor social competence and one of the few studies to examine the interrelations between components of social information processing, family functioning and social adjustment. The specific aims of this application are to 1) qualitatively describe caregivers' perspectives on the factors contributing t survivor social adjustment after treatment; 2) compare components of social information processing (social problem- solving, social affective functions, neurocognitive functioning) between pediatric brain tumor and solid tumor survivors and examine associations between components of social information processing and social adjustment over time; and 3) examine the influence of risk and resilience factors (treatment intensity, family functioning, parent-survivor relationship quality) on survivor social information processing and social adjustment. Methods: Participants will be recruited from The Cancer Center at The Children's Hospital of Philadelphia. A qualitative phase at the outset of the project with a separate sample of caregivers of long-term pediatric BT survivors will inform the prospective design by exploring perspectives on the factors that shape survivor social adjustment outcomes. In the longitudinal phase, participants will include survivors of pediatric brain tumor and survivors of pediatric soli tumor, ages 7-14, and a parent or caregiver. Data collection will occur about one month after the end of tumor-directed treatment and again one and two years later. Assessments at each time point will include measures of survivor social information processing, neurocognitive functioning, social skills and social adjustment, as well as family functioning and parent-survivor relationship quality. It is hypothesized that(1) pediatric brain tumor survivors will have worse social information processing than solid tumor survivors, (2) poorer social-affective function and social problem-solving will be associated with worse survivor social adjustment over time, (3) neurocognitive functioning will be associated with poorer social-affective functioning, social problem-solving and social adjustment, and (4) better family functioning at baseline will be associated with smaller declines across domains of social information processing and social adjustment over time. Career Goals: This K07 award will provide the necessary training and mentorship for Matthew Hocking, Ph.D. to become an independent clinical researcher and leader in the field of pediatric psycho-oncology and pediatric neuro-oncology survivorship. Through this award, Dr. Hocking will 1) gain expertise in specific content areas relevant to understanding the interplay between biological, psychological and social context factors in contributing to survivor psychosocial outcomes; 2) acquire expertise in methodological (e.g., healthcare economics, cognitive neuroscience) and statistical approaches to examining the neurodevelopmental late effects of pediatric brain tumor survivors; 3) enhance skills related to the development and testing of psychosocial interventions directed at improving the social functioning of pediatric cancer survivors; and 4) advance scientific skills in grant writing and peer-reviewed research publication. To advance these training goals, Dr. Hocking has assembled a highly experienced mentorship team, led by Drs. Lamia Barakat and Anne Kazak, and a carefully constructed training plan that includes coursework, seminars, journal clubs, national research conferences, writing groups, and different research lab experiences. With the outlined training and support associated with this award, Dr. Hocking will be well poised to initiate an independent research career dedicated to improving the social functioning and quality of life of pediatric brain tumor survivors Importance: Findings from this study could inform clinical care with childhood brain tumor patients and subsequent research among a broader group of survivors affected by central nervous system disease. This study might identify potential mechanisms that mitigate the effects of cancer treatment on survivor social functioning and improve quality of life for survivors and their families. The proposed K07 award will prepare Dr. Hocking to apply for R01-level funding to advance this research and for R21-level funding to pilot a family- based intervention directed at improving social adjustment outcomes in pediatric brain tumor survivors.

描述（由申请人提供）：儿童脑肿瘤幸存者经历了其疾病和相关医疗的重大神经认知和社会缺陷，这导致他们在儿童癌症幸存者中具有最差的健康与健康相关的生活质量。尽管幸存的脑肿瘤的儿童遇到了严重的社会调整困难（例如，友谊较少，被同龄人接受的较少），但很少研究随着时间的流逝检查了他们的社会能力或确定了他们社会调整的预测指标。其他小儿脑损伤人群（例如，创伤性脑损伤）的发现表明社会信息处理缺陷，并说明了家庭功能对社会结果的影响，但在小儿脑肿瘤幸存者中尚未探索这些关联。该提案将是对幸存者社会能力的首次认识的前瞻性研究，也是研究社会信息处理，家庭功能和社会调整组成部分之间相互关系的少数研究之一。本申请的具体目的是1）定性描述护理人员对促成T幸存者社会调整后的因素的观点； 2）比较小儿脑肿瘤与实体瘤幸存者之间的社会信息处理（社会问题解决，社会情感功能，神经认知功能）的组成部分，并检查社会信息处理的组成部分与社会调整的组成部分之间的关联； 3）检查风险和弹性因素（治疗强度，家庭功能，父母生活关系质量）对幸存者社会信息处理和社会调整的影响。方法：将从费城儿童医院的癌症中心招募参与者。项目开始时的定性阶段，由单独的长期儿科BT幸存者的护理人员样本来探讨塑造幸存者社会调整成果的因素的观点，以告知潜在的设计。在纵向阶段，参与者将包括儿科脑肿瘤的幸存者和7-14岁的小儿虫肿瘤的幸存者和父母或照料者。数据收集将发生在肿瘤定向治疗结束后的一个月后，然后在一年后再次发生。每个时间点的评估都将包括幸存者社会信息处理，神经认知功能，社交技能和社交调整以及家庭功能和父母生活关系的度量质量。假设（1）小儿脑肿瘤幸存者的社会信息处理要比实体瘤幸存者更糟糕，（2）（2）较差的社会影响力和解决社会问题将与较差的幸存者社交调整随着时间的推移而差，（3）神经认知功能与较小的社交能力和社交范围越来越多的社交能力和社交能力相关联，（4）与社交范围较小，社交能力较小，（4）与社交的能力相关联（4））随着时间的推移，社会信息处理和社会调整的领域。职业目标：该K07奖将为Matthew Hocking博士提供必要的培训和指导。成为小儿心理肿瘤学和儿科神经肿瘤学领域的独立临床研究人员和领导者。通过该奖项，Hocking博士将1）在与了解生物，心理和社会环境之间的相互作用相关的特定内容领域中获得专业知识，从而在为幸存者的心理社会成果促成贡献方面； 2）获得方法论方面的专业知识（例如医疗保健经济学，认知神经科学）和统计方法，用于检查小儿脑肿瘤幸存者的神经发育后期作用； 3）增强与旨在改善小儿癌症幸存者社会功能的社会心理干预措施的发展和测试有关的技能； 4）提高赠款写作和同行评审研究出版物的科学技能。为了促进这些培训目标，霍金博士召集了由Drs领导的经验丰富的指导团队。 Lamia Barakat和Anne Kazak，以及精心构建的培训计划，包括课程，研讨会，期刊俱乐部，国家研究会议，写作小组和不同的研究实验室经验。借助与该奖项相关的概述培训和支持，Hocking博士将有很好的准备启动独立的研究职业，致力于改善儿科脑肿瘤幸存者的社会功能和生活质量的重要性：这项研究的发现可以为儿童脑肿瘤患者以及由中心神经系统疾病影响更广泛的生存者的临床护理提供依据。这项研究可能会确定潜在的机制，以减轻癌症治疗对幸存者社会功能的影响并改善幸存者及其家人的生活质量。拟议的K07奖将使Hocking博士准备申请R01级资金，以推进这项研究，并为R21级资金提供基于家庭的干预措施，该干预旨在改善儿科脑肿瘤幸存者的社会调整结果。