Core D: Neuropathology Core

核心 D：神经病理学核心

• 批准号: 10374076
• 负责人: JUAN TRONCOSO
• 金额: $ 59.37万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10374076
• 关键词: Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease pathology; Alzheimer’s disease biomarker; Autopsy; Biochemistry; Biological; Biological Markers; Brain; Brain Diseases; Clinic; Clinical; Clinical Research; Cognitive; Communities; Consensus; Consultations; Data; Databases; Dementia; Development; Diagnosis; Diagnostic; Disease; Doctor of Philosophy; Drug or chemical Tissue Distribution; Electron Microscopy; Enrollment; Etiology; Evaluation; Faculty; Family; Genetically Engineered Mouse; Goals; Hippocampus (Brain); Histology; Human; Human Resources; Image; Institution; Investigation; Liquid substance; Molecular Biology; Morphology; Neuroanatomy; Neurobiology; Neurodegenerative Disorders; Neurology; Pamphlets; Participant; Pathogenesis; Pathologic; Physicians; Preparation; Progress Reports; Publications; Reporting; Research; Research Personnel; Resources; Services; Source; Specimen; Structure; Tissue Banks; Tissues; Training; Update; Work; base; biomarker development; brain tissue; clinical biomarkers; clinical center; clinical diagnosis; cohort; comorbidity; education research; immunocytochemistry; interest; neuroimaging; neuropathology; outreach; recruit; symposium

NEUROPATHOLOGY CORE – CORE D: PROJECT SUMMARY/ABSTRACT Postmortem examination remains critical to elucidate the etiology in cases of dementia and to confirm the diagnosis of AD, despite recent advances in neuroimaging and fluid biomarkers. Autopsy is also critical for confirming the clinical diagnosis and identifying comorbidities, which are common in older subjects. The Neuropathology Core (Core D) of the Johns Hopkins Alzheimer's Disease Research Center (JHADRC) has three overarching goals. The first is to conduct postmortem neuropathological assessments in subjects enrolled in the JHADRC Clinical Core. Second, to prepare, store, and distribute autopsy brain tissues for research. The third goal is the training of young physicians and neuroscientists in the neuropathology of dementias and neurodegenerative diseases. The specific aims of Core D are as follows: (1) to arrange and perform autopsies on clinically well-characterized subjects enrolled through the JHADRC and assist with consensus diagnoses on JHADRC subjects, (2) to store optimally prepared tissues from the autopsies and to make these specimens available to investigators associated with the JHADRC and at other collaborating institutions, (3) to integrate the neuropathologic data from these cases with the clinical and biomarker data acquired in the same participants, using the JHADRC database, and to submit the neuropathology data to the National Alzheimer's Coordinating Center (NACC), working with the Data Core (4) to support the assessment of genetically engineered mouse models relevant to Alzheimer's disease (AD) and related disorders, and (5) to train basic investigators and clinical neuroscientists in the morphological and diagnostic concepts relevant to AD, to other types of dementias and neurodegenerative disorders (including trainees supported by the REC). In addition, the availability of human brain postmortem tissues has become increasingly important for validating research hypotheses and for investigations and development of biomarkers of AD. Core D will therefore be expanding its postmortem tissue collection to include a large number of specimens from younger subjects (30 to 65 years) suitable to examine the very early stages of AD pathology and its pathogenesis.

神经病理学核心-核心D：项目摘要/摘要 尸检对于阐明痴呆症的病因和确认 诊断阿尔茨海默病，尽管最近在神经成像和液体生物标记物方面取得了进展。尸检也是关键 确认临床诊断并识别在老年受试者中常见的合并症。这个 约翰霍普金斯阿尔茨海默病研究中心(JHADRC)的神经病理学核心(D核心) 三个首要目标。第一种是对受试者进行死后神经病理学评估。 参加了JHADRC临床核心项目。第二，准备、储存和分发尸检脑组织 研究。第三个目标是对年轻的内科医生和神经科学家进行神经病理学方面的培训 痴呆症和神经退行性疾病。核心D的具体目标如下：(1)安排和 对通过JHADRC登记的具有良好临床特征的受试者进行尸检，并协助 对JHADRC受试者的共识诊断，(2)存储来自身体解剖的最佳准备组织，并 将这些标本提供给与JHADRC有关的调查人员和其他合作组织 机构，(3)将这些病例的神经病理数据与临床和生物标记物数据相结合 使用JHADRC数据库在同一参与者中获得，并将神经病理数据提交给 国家阿尔茨海默氏症协调中心(NACC)，与数据核心(4)合作支持评估 与阿尔茨海默病(AD)和相关疾病相关的基因工程小鼠模型，以及(5) 对基础研究人员和临床神经学家进行有关以下方面的形态和诊断概念的培训 AD，适用于其他类型的痴呆症和神经退行性疾病(包括由REC支持的受训人员)。 此外，人脑死后组织的可用性对于验证变得越来越重要 研究假说以及AD生物标志物的调查和开发。因此，核心D将是 扩大其死后组织收集，以包括大量来自年轻受试者的标本(30 至65岁)适合于研究AD的病理及其发病机制的非常早期阶段。