Research Education Program in Experimental Neuropathology

实验神经病理学研究教育计划

• 批准号: 8330473
• 负责人: JUAN TRONCOSO
• 金额: $ 5.17万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8330473
• 关键词: Administrative Supplement; Alzheimer' s Disease; Animal Model; Applications Grants; Award; Basic Science; Biological Markers; Biomedical Research; Clinical; Clinical Medicine; Communication; Dementia; Development; Diagnosis; Diagnostic tests; Disease; Education; Education Projects; Epilepsy; Ethics; Faculty; Fellowship; Funding; Goals; Grant; Human; Immersion Investigative Technique; Individual; Instruction; K-Series Research Career Programs; Laboratories; Mentored Patient-Oriented Research Career Development Award; Mentors; Microscopic; Molecular; Molecular Biology; Molecular Genetics; Monitor; Morbidity - disease rate; Neurodegenerative Disorders; Neurosciences; Oral; Parkinson Disease; Participant; Pathology; Peer Review; Physicians; Play; Preparation; Prevention; Process; Productivity; Public Health; Publications; Qualifying; Records; Recruitment Activity; Research; Research Activity; Research Personnel; Research Project Grants; Residencies; Scholarship; Science; Scientist; Staging; Stroke; Time; Tissues; Training; Training Programs; Translating; Traumatic Brain Injury; United States National Institutes of Health; Work; Writing; base; career; cellular imaging; clinical application; experience; insight; medical schools; mortality; multidisciplinary; nervous system disorder; neuro-oncology; neuropathology; next generation; novel; novel diagnostics; programs; relating to nervous system; skills; success; tool

DESCRIPTION (provided by applicant): There is a shortage of physician-scientists who can bridge basic research and clinical neurosciences. These are the individuals who can take the discoveries of basic science and use them to understand the mechanisms of neurological disorders such as Alzheimer's or Parkinson's disease or stroke, and to develop novel treatments and biomarkers. Neuropathologists play a key role in this process, as they are specifically trained to study the microscopic and molecular manifestations of disease. They can provide critical insights into the changes present in human neural tissues, as well as those of animal models and based on their unique perspective can generate novel hypotheses or form an essential part of multidisciplinary teams studying neurological disease. The goal of the Johns Hopkins Research Education Program in Experimental Neuropathology is to provide neuropathology residents and fellows with an intensive, mentored research experience during their residency or fellowship. This early immersion in research will help them to develop a research career and prepare them to successfully apply for NIH career development awards (KO8 and K23). To attain this goal, we have assembled a group of highly qualified mentors, both from neuropathology and other neurosciences departments, who will guide the research activities of the trainees. These mentors are physician-scientists and basic researchers with strong track records of independent funding and research, scholarship, and previous training of physician-scientists. Trainees will be selected based on their potential for becoming independent investigators and will be admitted to the program while in their neuropathology residency or fellowship. The trainees will then work for one or two years in the laboratory of a mentor, who will guide and supervise them. The plan for research will be jointly developed by the trainee and mentor and approved by the Program Executive Committee. The trainees will also attend courses in the ethical conduct of research and professional development (grant writing). They will also be able to apply for an Administrative Supplement of the award to extend their research experience once they complete their clinical training. While in the program, the trainees will start writing applications for KO8 or K23 awards. The success of the program will be evaluated by the number of trainees that apply for and succeed in obtaining career development awards (i.e. KO8 and K23) or other major research grants (i.e. R01), pursue research and academic careers, and author significant peer-reviewed publications. PUBLIC HEALTH RELEVANCE: Public Health Diseases of the nervous system such as dementia, stroke, epilepsy, and traumatic brain injury are common causes or morbidity and mortality. There is an urgent need to find new ways to diagnose and cure these conditions. New advances in basic sciences, including cell imaging, molecular biology and genetics, have created great opportunities that need to be translated into diagnostic tests and therapies for these neurological disorders. This R25 Neuropathology Research Education Program aims to train physician-scientists focused on Neuropathology who will be able to bridge the gap between basic research and clinical medicine, and to develop the next generation of diagnostic tools and therapies for neurological disorders.

描述（由申请人提供）：缺乏能够连接基础研究和临床神经科学的医生科学家。这些人可以利用基础科学的发现，并利用它们来了解阿尔茨海默氏症或帕金森氏症或中风等神经系统疾病的机制，并开发新的治疗方法和生物标志物。神经病理学家在这一过程中发挥着关键作用，因为他们受过专门训练，可以研究疾病的微观和分子表现。他们可以对人类神经组织中存在的变化以及动物模型的变化提供关键的见解，并基于他们独特的视角可以产生新的假设或形成研究神经系统疾病的多学科团队的重要组成部分。约翰霍普金斯实验神经病理学研究教育计划的目标是为神经病理学住院医师和研究员在住院医师或研究员期间提供密集的，指导性的研究经验。这种早期沉浸在研究中将帮助他们发展研究生涯，并为他们成功申请NIH职业发展奖（KO 8和K23）做好准备。为了实现这一目标，我们召集了一批来自神经病理学和其他神经科学部门的高素质导师，他们将指导学员的研究活动。这些导师是物理科学家和基础研究人员，在独立资助和研究、奖学金以及物理科学家之前的培训方面拥有良好的记录。学员将根据他们成为独立研究者的潜力进行选择，并将在他们的神经病理学住院或奖学金期间被录取。然后，受训人员将在导师的实验室工作一到两年，导师将指导和监督他们。研究计划将由学员和导师共同制定，并由项目执行委员会批准。受训人员还将参加研究道德行为和专业发展（赠款撰写）课程。他们还可以申请该奖项的行政补充，以延长他们的研究经验，一旦他们完成临床培训。在项目期间，学员将开始撰写KO 8或K23奖项的申请。该计划的成功将通过申请并成功获得职业发展奖（即KO 8和K23）或其他主要研究赠款（即R 01），追求研究和学术生涯以及作者重要同行评审出版物的受训人员数量进行评估。 公共卫生关系：神经系统疾病如痴呆、中风、癫痫和创伤性脑损伤是发病和死亡的常见原因。迫切需要找到新的方法来诊断和治疗这些疾病。基础科学的新进展，包括细胞成像、分子生物学和遗传学，创造了巨大的机会，需要转化为这些神经系统疾病的诊断测试和治疗。该R25神经病理学研究教育计划旨在培养专注于神经病理学的医生-科学家，他们将能够弥合基础研究和临床医学之间的差距，并开发下一代神经疾病的诊断工具和疗法。