Research Education Program in Experimental Neuropathology

实验神经病理学研究教育计划

• 批准号: 8473930
• 负责人: JUAN TRONCOSO
• 金额: --
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8473930
• 关键词: Administrative Supplement; Alzheimer' s Disease; Animal Model; Applications Grants; Award; Basic Science; Biological Markers; Biomedical Research; Clinical; Clinical Medicine; Communication; Dementia; Development; Diagnosis; Diagnostic tests; Disease; Education; Education Projects; Epilepsy; Ethics; Faculty; Fellowship; Funding; Goals; Grant; Human; Immersion Investigative Technique; Individual; Instruction; K-Series Research Career Programs; Laboratories; Mentored Patient-Oriented Research Career Development Award; Mentors; Microscopic; Molecular; Molecular Biology; Molecular Genetics; Monitor; Morbidity - disease rate; Neurodegenerative Disorders; Neurosciences; Oral; Parkinson Disease; Participant; Pathology; Peer Review; Physicians; Play; Preparation; Prevention; Process; Productivity; Public Health; Publications; Qualifying; Records; Recruitment Activity; Research; Research Activity; Research Personnel; Research Project Grants; Residencies; Scholarship; Science; Scientist; Staging; Stroke; Time; Tissues; Training; Training Programs; Translating; Traumatic Brain Injury; United States National Institutes of Health; Work; Writing; base; career; cellular imaging; clinical application; experience; insight; medical schools; mortality; multidisciplinary; nervous system disorder; neuro-oncology; neuropathology; next generation; novel; novel diagnostics; programs; public health relevance; relating to nervous system; skills; success; tool

DESCRIPTION (provided by applicant): There is a shortage of physician-scientists who can bridge basic research and clinical neurosciences. These are the individuals who can take the discoveries of basic science and use them to understand the mechanisms of neurological disorders such as Alzheimer's or Parkinson's disease or stroke, and to develop novel treatments and biomarkers. Neuropathologists play a key role in this process, as they are specifically trained to study the microscopic and molecular manifestations of disease. They can provide critical insights into the changes present in human neural tissues, as well as those of animal models and based on their unique perspective can generate novel hypotheses or form an essential part of multidisciplinary teams studying neurological disease. The goal of the Johns Hopkins Research Education Program in Experimental Neuropathology is to provide neuropathology residents and fellows with an intensive, mentored research experience during their residency or fellowship. This early immersion in research will help them to develop a research career and prepare them to successfully apply for NIH career development awards (KO8 and K23). To attain this goal, we have assembled a group of highly qualified mentors, both from neuropathology and other neurosciences departments, who will guide the research activities of the trainees. These mentors are physician-scientists and basic researchers with strong track records of independent funding and research, scholarship, and previous training of physician-scientists. Trainees will be selected based on their potential for becoming independent investigators and will be admitted to the program while in their neuropathology residency or fellowship. The trainees will then work for one or two years in the laboratory of a mentor, who will guide and supervise them. The plan for research will be jointly developed by the trainee and mentor and approved by the Program Executive Committee. The trainees will also attend courses in the ethical conduct of research and professional development (grant writing). They will also be able to apply for an Administrative Supplement of the award to extend their research experience once they complete their clinical training. While in the program, the trainees will start writing applications for KO8 or K23 awards. The success of the program will be evaluated by the number of trainees that apply for and succeed in obtaining career development awards (i.e. KO8 and K23) or other major research grants (i.e. R01), pursue research and academic careers, and author significant peer-reviewed publications.

描述（由申请人提供）：目前缺乏能够在基础研究和临床神经科学之间架起桥梁的内科科学家。这些人可以利用基础科学的发现来理解神经系统疾病的机制，如阿尔茨海默氏症、帕金森病或中风，并开发新的治疗方法和生物标志物。神经病理学家在这一过程中起着关键作用，因为他们受过专门的训练，研究疾病的微观和分子表现。它们可以为人类神经组织以及动物模型中存在的变化提供关键的见解，并且基于它们独特的视角可以产生新的假设或形成研究神经系统疾病的多学科团队的重要组成部分。约翰霍普金斯大学实验神经病理学研究教育计划的目标是为神经病理学住院医师和研究员提供密集的指导研究经验。这种早期的研究沉浸将帮助他们发展研究事业，并为他们成功申请NIH职业发展奖（KO8和K23）做好准备。为了实现这一目标，我们从神经病理学和其他神经科学部门召集了一群高素质的导师，他们将指导学员的研究活动。这些导师是内科科学家和基础研究人员，他们在独立资助和研究、奖学金和之前的内科科学家培训方面有着良好的记录。学员将根据他们成为独立研究者的潜力进行选择，并将在他们的神经病理学住院医师或研究员期间进入该项目。然后，受训者将在导师的实验室工作一到两年，导师将指导和监督他们。研究计划将由学员和导师共同制定，并由项目执行委员会批准。受训者还将参加有关研究和专业发展的道德行为（拨款写作）的课程。一旦完成临床培训，他们还可以申请该奖项的行政补充，以扩展他们的研究经验。在此期间，学员们将开始撰写KO8或K23奖项的申请。该计划的成功与否将根据申请并成功获得职业发展奖励（即KO8和K23）或其他重大研究资助（即R01），从事研究和学术事业以及撰写重要同行评审出版物的学员人数来评估。