Connected Lives - Overcoming the Self through Empathy (CLOSE): A Dyadic, Multi-Method Study

互联生活 - 通过同理心克服自我（关闭）：二元、多方法研究

• 批准号: 10376271
• 负责人: Jessica Renee Andrews-Hanna
• 金额: $ 63.26万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10376271
• 关键词: 3-Dimensional; Address; Adult; Affect; Anxiety; Area; Behavior; Behavioral; Brain; Couples; Data; Emotional; Emotional disorder; Emotions; Empathy; Feedback; Feeling; Functional Magnetic Resonance Imaging; Future; Goals; Health; Heart; Hostility; Impaired health; Impairment; Individual; Intervention; Life; Light; Link; Loneliness; Measures; Mediating; Mental Depression; Mental Health; Mental disorders; Methods; Mind; Modeling; Outcome; Participant; Partner in relationship; Patient Self-Report; Pattern; Personal Satisfaction; Psyche structure; Psychopathology; Questionnaires; Research; Research Design; Research Personnel; Risk; Risk Factors; Role; Sampling; Scientific Advances and Accomplishments; Services; Shapes; Social Behavior; Stress; Symptoms; Testing; Thinking; Time; Work; biopsychosocial factor; brain behavior; design; healthspan; improved; interest; member; middle age; mobile application; negative affect; neuroimaging; novel; primary outcome; prospective; relating to nervous system; smartphone Application; social; social factors; social integration; social relationships; statistics; trait; young adult

PROJECT SUMMARY This project seeks to shed light on mechanisms underlying transdiagnostic risk for mental illness by integrating two traditionally disparate lines of research. One line of work indicates that repetitive negative thinking (RNT)—a transdiagnostic risk factor characterized by frequent, negative, self-focused thoughts— increases vulnerability for a range of mental health disorders, including depression and anxiety. A second line of work demonstrates that high-quality social relationships are associated with lower rates of mental and physical illness; conversely, relationship stress, hostility, and disconnection exacerbate loneliness, isolation, and mental and physical illness. This proposal will test a new model in which RNT and social connectedness work together as parts of an integrated whole. The central argument of this model is that RNT exerts its pernicious effects on mental health by impairing the ability to meaningfully connect with others through empathy—a critical component of social connection that involves sharing and understanding others’ emotions. Critical to this model is the hypothesis that RNT and empathy operate dyadically; that is, they affect both partners in a close relationship. To test this model, this project will implement a multilevel research design that integrates self-report, neuroimaging, and naturalistic observation to study RNT, social connection, and mental health in the context of established close relationships. Specifically, the project will employ a multi-method approach across 200 established romantic couples (young adults to those in middle age; N = 400) to assess the following aims: (1) Examine associations between RNT and partner-directed neural and behavioral empathy among romantic couples; (2) Determine the role of neural empathy in dyadic social-emotional and mental health outcomes; (3) Determine the role of RNT in dyadic mental health outcomes; and (4) Examine whether neural empathy mediates the dyadic association between RNT and longitudinal mental health outcomes. Advancing prior work, the proposed research will examine neural empathy in a novel and validated social feedback task using functional MRI in each member of the couple, to be modelled using dyadic statistics. Additionally, RNT and daily social behaviors will be assessed in everyday life using two mobile apps developed by the research team: Mind Window and the Electronically Activated Recorder (EAR). Finally, mental health will be assessed over 6 months to allow for prospective changes in the primary outcomes of interest. To tackle the study’s aims, this proposal brings together an interdisciplinary team of researchers with expertise spanning all facets of the proposed research: RNT, depression, neural empathy, social connectedness, dyadic modelling, and ambulatory assessment. Ultimately, this work holds promise for advancing scientific understanding of how individual and social risks for psychopathology operate together to shape emotional disorders. In turn, this research has the potential to help identify novel intervention targets to strengthen social connectedness in service of improving mental health.

项目摘要 该项目旨在通过以下方式揭示精神疾病转诊风险的潜在机制： 整合了两个传统上完全不同的研究方向。一种工作方式表明， 思维（RNT）-一种以频繁，消极，自我为中心的想法为特征的transdiagnosis风险因素- 增加了对一系列精神健康障碍的脆弱性，包括抑郁和焦虑。第二线 的工作表明，高质量的社会关系与较低的精神和 身体疾病;相反，关系压力，敌意，断开加剧孤独，孤立， 以及精神和身体疾病。这项提案将测试一个新的模型，其中RNT和社会联系 作为一个整体的一部分一起工作。该模型的核心论点是，RNT发挥其 通过损害与他人有意义地联系的能力，对心理健康产生有害影响， 同理心-社会联系的一个重要组成部分，涉及分享和理解他人的情绪。 这个模型的关键是假设RNT和共情是二元运作的，也就是说，它们同时影响两者 亲密关系中的伙伴。为了检验这个模型，本项目将实施一个多层次的研究设计， 整合自我报告，神经影像学和自然观察研究RNT，社会联系和心理 在已建立的密切关系的背景下的健康。具体而言，该项目将采用多种方法 对200对成熟的浪漫情侣（年轻人到中年人; N = 400）进行评估 本研究的主要目的是：（1）研究RNT与伙伴定向的神经和行为之间的关系 （2）确定神经共情在二元社会情感和 心理健康结果;（3）确定RNT在二元心理健康结果中的作用;（4）检查 神经移情是否介导RNT和纵向心理健康之间的二元关联 成果。推进先前的工作，拟议的研究将在一个新的和验证的 社会反馈任务，使用功能磁共振成像在每一个成员的夫妇，要模拟使用二元 统计此外，将使用两个移动的应用程序在日常生活中评估RNT和日常社交行为 由研究小组开发的：心灵之窗和电子激活记录器（Mind Window and the Electronically Activated Recorder，缩写为EAI）。最后， 将在6个月内评估心理健康，以考虑主要结局的前瞻性变化， 兴趣为了实现这项研究的目标，这项提议汇集了一个跨学科的研究人员团队， 专业知识涵盖了拟议研究的各个方面：RNT，抑郁症，神经同理心，社会 连通性、二元建模和动态评估。最终，这项工作有望 推进对精神病理学的个人和社会风险如何共同运作的科学理解， 形成情绪障碍反过来，这项研究有可能帮助确定新的干预目标， 加强社会联系，为改善心理健康服务。