Tracking autobiographical thoughts: a smartphone-based approach to identifying cognitive correlates of Alzheimer's disease biomarkers and risk factors in clinically normal older adults
追踪自传体思想:一种基于智能手机的方法,用于识别临床正常老年人阿尔茨海默病生物标志物和危险因素的认知相关性
基本信息
- 批准号:10680538
- 负责人:
- 金额:$ 84.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-15 至 2028-04-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAdultAgeAgingAlzheimer disease detectionAlzheimer&aposs DiseaseAlzheimer&aposs Disease PathwayAlzheimer&aposs disease pathologyAlzheimer&aposs disease riskAlzheimer’s disease biomarkerAmericanAmyloidAmyloid beta-ProteinApolipoprotein EAutobiographyBiological AssayBiological MarkersBiology of AgingBrainCause of DeathCellular PhoneCharacteristicsClassificationClinicalClinical PathologyClinical TrialsCognitionCognitiveCollaborationsDataDementiaDeveloping CountriesDiseaseDisease ProgressionEarly DiagnosisEarly treatmentElderlyEnrollmentEvaluationFrequenciesFunctional Magnetic Resonance ImagingFutureGenesGenetic RiskGenotypeGoalsHealthHomeImpaired cognitionIndividualInterventionLifeLongevityMeasuresMemoryMethodsMindNational Institute on AgingNeurocognitiveNeuropsychological TestsOnline SystemsOutcomePatientsPhasePhosphorylationPlasmaPreventionProcessPsyche structurePublic HealthResearchResearch PersonnelRestRisk FactorsScientistSpecificityTestingThinkingTimeUnderserved PopulationUnited StatesWorkage effectaging brainbrain pathwayclinical carecognitive changecognitive testingcohortdaily functioningdisabilitydisease prognosisearly detection biomarkerseffective therapyfollow-upfunctional declinegenetic testinghealthy agingimprovedindexinginnovationlaboratory experimentlarge datasetslongitudinal analysismiddle agemild cognitive impairmentmultimodalityneuroimagingneuroimaging markerneuropathologynormal agingpathological agingpre-clinicalpsychosocialrecruitsimulationsmartphone applicationsmartphone based assessmentsociodemographic grouptau Proteinstoolunderserved communityyoung adult
项目摘要
While the earliest phase of Alzheimer’s disease (AD) pathology is often described as “clinically silent”, prior work
raises the possibility that early AD is associated with detectable alterations in autobiographical thought – a class
of cognition encompassing memories, plans, and other mental simulations related to our personal lives. Here
we introduce two multi-modal studies that investigate whether cognitive markers of early AD neuropathology can
be detected by deploying smartphone applications (apps) to track autobiographical thoughts in everyday life.
Using two smartphone apps developed by our team to naturalistically assess cognition, the proposed studies
will a) examine the sensitivity of real-world autobiographical thoughts to AD plasma and brain biomarkers in
clinically normal older adults, b) reveal the predictive and scalable potential of measuring autobiographical
thoughts in older adults for a host of longitudinal AD biomarker and associated health outcomes, and c) shed
light on neurocognitive autobiographical thought characteristics that may separate normal from abnormal
cognitive and brain aging. MPIs Dr. Grilli and Dr. Andrews-Hanna have formed a team of researchers with
expertise in smartphone-based assessment of cognition, autobiographical thought, functional magnetic
resonance imaging, healthy and pathological aging, and longitudinal analysis of large datasets. Leveraging our
team’s interdisciplinary expertise, we will execute an innovative two-pronged project harnessing in-lab, at-home,
and online assessment methods that will evaluate the relationships of AD biomarkers and aging to the
autobiographical thoughts of 1,225+ adults, with a subset completing additional in-lab experimental cognitive
tests, neuroimaging, plasma biomarker assays, and longitudinal follow-up. In Aim 1, we will test the hypothesis
that among clinically normal older adults, smartphone measures of autobiographical thoughts are sensitive to
plasma AD biomarkers, and resting state functional connectivity in the default network, a brain network targeted
by early AD. Aim 2 tests the hypothesis that these smartphone measures predict future plasma biomarker
accumulation among older adults who were clinically normal at enrollment, as well as future resting state
functional connectivity of the default network, and daily psychosocial / instrumental decline. Aim 3 deploys one
of our smartphone apps to a large remote, clinically normal, and genotyped cohort, providing an opportunity to
evaluate questions about effects of age and genetic risk for AD on autobiographical thoughts at an
unprecedented scale. Across the aims, we also examine how smartphone measures of autobiographical
thoughts compare to in-lab cognitive tests, and if they improve sensitivity to aging and AD risk. To our knowledge,
this project will be the first to use smartphones to track autobiographical thoughts as a means to identify cognitive
correlates of AD biomarkers, despite theoretical tenets and evidence that doing so could tap into the primary
brain pathway of AD. Ultimately, our mobile tools may lead to more accessible cognitive tests of early AD,
including initial stages of amyloid and tau, with broad impact for scientists, clinicians and patients worldwide.
虽然阿尔茨海默病(AD)病理的早期阶段通常被描述为“临床沉默”,但先前的工作
项目成果
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Jessica Renee Andrews-Hanna其他文献
Jessica Renee Andrews-Hanna的其他文献
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{{ truncateString('Jessica Renee Andrews-Hanna', 18)}}的其他基金
Tracking autobiographical thoughts: a smartphone-based approach to identifying cognitive correlates of Alzheimer's disease biomarkers and risk factors in clinically normal older adults
追踪自传体思想:一种基于智能手机的方法,用于识别临床正常老年人阿尔茨海默病生物标志物和危险因素的认知相关性
- 批准号:
10523836 - 财政年份:2022
- 资助金额:
$ 84.02万 - 项目类别:
Connected Lives - Overcoming the Self through Empathy (CLOSE): A Dyadic, Multi-Method Study
互联生活 - 通过同理心克服自我(关闭):二元、多方法研究
- 批准号:
10559597 - 财政年份:2021
- 资助金额:
$ 84.02万 - 项目类别:
Connected Lives - Overcoming the Self through Empathy (CLOSE): A Dyadic, Multi-Method Study
互联生活 - 通过同理心克服自我(关闭):二元、多方法研究
- 批准号:
10376271 - 财政年份:2021
- 资助金额:
$ 84.02万 - 项目类别:
Tracking autobiographical thoughts: a smartphone-based approach to the detection of cognitive and neural markers of Alzheimer's disease risk
追踪自传思想:一种基于智能手机的方法来检测阿尔茨海默病风险的认知和神经标记
- 批准号:
10228998 - 财政年份:2020
- 资助金额:
$ 84.02万 - 项目类别:
The Neural Basis of Executive Control of Internally-Directed Attention
内部定向注意力执行控制的神经基础
- 批准号:
8003432 - 财政年份:2011
- 资助金额:
$ 84.02万 - 项目类别:
The Neural Basis of Executive Control of Internally-Directed Attention
内部定向注意力执行控制的神经基础
- 批准号:
8262044 - 财政年份:2011
- 资助金额:
$ 84.02万 - 项目类别:
The Neural Basis of Executive Control of Internally-Directed Attention
内部定向注意力执行控制的神经基础
- 批准号:
8424142 - 财政年份:2011
- 资助金额:
$ 84.02万 - 项目类别:
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