Tracking autobiographical thoughts: a smartphone-based approach to identifying cognitive correlates of Alzheimer's disease biomarkers and risk factors in clinically normal older adults
追踪自传体思想:一种基于智能手机的方法,用于识别临床正常老年人阿尔茨海默病生物标志物和危险因素的认知相关性
基本信息
- 批准号:10523836
- 负责人:
- 金额:$ 89.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-15 至 2027-04-30
- 项目状态:未结题
- 来源:
- 关键词:AdultAgeAgingAlzheimer&aposs DiseaseAlzheimer&aposs Disease PathwayAlzheimer&aposs disease pathologyAlzheimer&aposs disease riskAlzheimer’s disease biomarkerAmericanAmyloidAmyloid beta-ProteinApolipoprotein EBiological AssayBiological MarkersBiology of AgingBrainCause of DeathCellular PhoneCharacteristicsClinicalClinical PathologyClinical TrialsCognitionCognitiveCollaborationsDataDiseaseDisease ProgressionEarly DiagnosisEarly treatmentElderlyEnrollmentEvaluationFrequenciesFunctional Magnetic Resonance ImagingFutureGenesGenetic RiskGenotypeGoalsHealthHomeImpaired cognitionIndividualInterventionLeadLifeLightLongevityMeasuresMemoryMethodsMindNational Institute on AgingNeurocognitiveNeuropsychological TestsOnline SystemsOutcomePatientsPhasePlasmaPreventionProcessPsyche structurePublic HealthResearchResearch PersonnelRestRisk FactorsScientistSpecificityTestingThinkingTimeUnderserved PopulationUnited StatesWorkage effectaging brainbasebrain pathwayclinical carecognitive changecognitive testingcohortdaily functioningdisabilitydisease prognosisearly detection biomarkerseffective therapyfollow-upfunctional declinegenetic testinghealthy agingimprovedindexinginnovationlarge datasetslongitudinal analysismiddle agemild cognitive impairmentmultimodalityneuroimagingneuroimaging markerneuropathologynormal agingpathological agingpre-clinicalpsychosocialrecruitsimulationsmartphone Applicationsmartphone based assessmentsociodemographic grouptau Proteinstau-1toolunderserved communityyoung adult
项目摘要
While the earliest phase of Alzheimer’s disease (AD) pathology is often described as “clinically silent”, prior work
raises the possibility that early AD is associated with detectable alterations in autobiographical thought – a class
of cognition encompassing memories, plans, and other mental simulations related to our personal lives. Here
we introduce two multi-modal studies that investigate whether cognitive markers of early AD neuropathology can
be detected by deploying smartphone applications (apps) to track autobiographical thoughts in everyday life.
Using two smartphone apps developed by our team to naturalistically assess cognition, the proposed studies
will a) examine the sensitivity of real-world autobiographical thoughts to AD plasma and brain biomarkers in
clinically normal older adults, b) reveal the predictive and scalable potential of measuring autobiographical
thoughts in older adults for a host of longitudinal AD biomarker and associated health outcomes, and c) shed
light on neurocognitive autobiographical thought characteristics that may separate normal from abnormal
cognitive and brain aging. MPIs Dr. Grilli and Dr. Andrews-Hanna have formed a team of researchers with
expertise in smartphone-based assessment of cognition, autobiographical thought, functional magnetic
resonance imaging, healthy and pathological aging, and longitudinal analysis of large datasets. Leveraging our
team’s interdisciplinary expertise, we will execute an innovative two-pronged project harnessing in-lab, at-home,
and online assessment methods that will evaluate the relationships of AD biomarkers and aging to the
autobiographical thoughts of 1,225+ adults, with a subset completing additional in-lab experimental cognitive
tests, neuroimaging, plasma biomarker assays, and longitudinal follow-up. In Aim 1, we will test the hypothesis
that among clinically normal older adults, smartphone measures of autobiographical thoughts are sensitive to
plasma AD biomarkers, and resting state functional connectivity in the default network, a brain network targeted
by early AD. Aim 2 tests the hypothesis that these smartphone measures predict future plasma biomarker
accumulation among older adults who were clinically normal at enrollment, as well as future resting state
functional connectivity of the default network, and daily psychosocial / instrumental decline. Aim 3 deploys one
of our smartphone apps to a large remote, clinically normal, and genotyped cohort, providing an opportunity to
evaluate questions about effects of age and genetic risk for AD on autobiographical thoughts at an
unprecedented scale. Across the aims, we also examine how smartphone measures of autobiographical
thoughts compare to in-lab cognitive tests, and if they improve sensitivity to aging and AD risk. To our knowledge,
this project will be the first to use smartphones to track autobiographical thoughts as a means to identify cognitive
correlates of AD biomarkers, despite theoretical tenets and evidence that doing so could tap into the primary
brain pathway of AD. Ultimately, our mobile tools may lead to more accessible cognitive tests of early AD,
including initial stages of amyloid and tau, with broad impact for scientists, clinicians and patients worldwide.
虽然阿尔茨海默氏病(AD)病理的最早阶段通常被描述为“临床沉默”,但先前的工作
提高了早期广告与自传思想的可检测变化相关的可能性 - 班级
认知涵盖了与我们个人生活有关的记忆,计划和其他心理模拟。这里
我们介绍了两项多模式研究,研究了早期AD神经病理学的认知标志物是否可以
可以通过部署智能手机应用程序(APP)来检测,以跟踪日常生活中的自传思想。
拟议的研究,使用我们团队开发的两个智能手机应用自然评估认知
a)检查现实世界自传思想对AD血浆和脑生物标志物的敏感性
临床上正常的老年人,b)揭示了自传的预测性和可扩展潜力
老年人的想法是许多纵向AD生物标志物和相关的健康结果的想法,c)棚屋
神经认知自传思想特征的光线可能与异常分开
认知和大脑衰老。 MPIS Grilli博士和Andrews-Hanna博士与
基于智能手机的认知评估,自传思想,功能磁性的专业知识
共振成像,健康和病理老化以及大数据集的纵向分析。利用我们的
团队的跨学科专业知识,我们将执行一个创新的两管齐下的项目,利用在家中,在家中
和在线评估方法,将评估广告生物标志物的关系和衰老与
1,225多名成年人的自传思想,一个子集完成了其他实验性认知
测试,神经影像学,血浆生物标志物测定和纵向随访。在AIM 1中,我们将检验假设
在临床正常的老年人中,自传思想的智能手机度量对
等离子体AD生物标志物以及默认网络中的静止状态功能连接,该网络的针对性
由早期广告。 AIM 2检验了这些智能手机措施预测未来血浆生物标志物的假设
在入学临床正常以及将来休息状态的老年人中积累
默认网络的功能连通性以及日常的社会心理 /工具下降。 AIM 3部署一个
我们的智能手机应用程序到一个大型遥控,临床正常和基因分型的队列,提供了机会
评估有关AD的年龄和遗传风险对自传思想影响的影响的问题
空前的量表。在整个目标中,我们还研究了自传智能手机的测量
思想与实验室内认知测试相比,以及它们是否提高对衰老和AD风险的敏感性。据我们所知,
该项目将是第一个使用智能手机跟踪自传思想作为识别认知的手段的项目
广告生物标志物,dospite理论宗旨和这样做的证据的相关性可以利用主要
AD的大脑通路。最终,我们的移动工具可能会导致对早期广告的更容易获得的认知测试,
包括淀粉样蛋白和TAU的初始阶段,对全球科学家,临床医生和患者产生广泛影响。
项目成果
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Jessica Renee Andrews-Hanna其他文献
Jessica Renee Andrews-Hanna的其他文献
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{{ truncateString('Jessica Renee Andrews-Hanna', 18)}}的其他基金
Tracking autobiographical thoughts: a smartphone-based approach to identifying cognitive correlates of Alzheimer's disease biomarkers and risk factors in clinically normal older adults
追踪自传体思想:一种基于智能手机的方法,用于识别临床正常老年人阿尔茨海默病生物标志物和危险因素的认知相关性
- 批准号:
10680538 - 财政年份:2022
- 资助金额:
$ 89.48万 - 项目类别:
Connected Lives - Overcoming the Self through Empathy (CLOSE): A Dyadic, Multi-Method Study
互联生活 - 通过同理心克服自我(关闭):二元、多方法研究
- 批准号:
10559597 - 财政年份:2021
- 资助金额:
$ 89.48万 - 项目类别:
Connected Lives - Overcoming the Self through Empathy (CLOSE): A Dyadic, Multi-Method Study
互联生活 - 通过同理心克服自我(关闭):二元、多方法研究
- 批准号:
10376271 - 财政年份:2021
- 资助金额:
$ 89.48万 - 项目类别:
Tracking autobiographical thoughts: a smartphone-based approach to the detection of cognitive and neural markers of Alzheimer's disease risk
追踪自传思想:一种基于智能手机的方法来检测阿尔茨海默病风险的认知和神经标记
- 批准号:
10228998 - 财政年份:2020
- 资助金额:
$ 89.48万 - 项目类别:
The Neural Basis of Executive Control of Internally-Directed Attention
内部定向注意力执行控制的神经基础
- 批准号:
8003432 - 财政年份:2011
- 资助金额:
$ 89.48万 - 项目类别:
The Neural Basis of Executive Control of Internally-Directed Attention
内部定向注意力执行控制的神经基础
- 批准号:
8262044 - 财政年份:2011
- 资助金额:
$ 89.48万 - 项目类别:
The Neural Basis of Executive Control of Internally-Directed Attention
内部定向注意力执行控制的神经基础
- 批准号:
8424142 - 财政年份:2011
- 资助金额:
$ 89.48万 - 项目类别:
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