Increasing physical activity among breast cancer survivors: Use of the ORBIT Model to refine and test a novel approach to exercise promotion based on affect-regulation

项目摘要/摘要 本次K08临床科学家导师研究职业发展奖的目标是为 独立研究事业的候选人 经常锻炼的乳腺癌幸存者 行为肿瘤学和健康行为干预科学。 癌症后诊断不太可能死于癌症，甚至 体力活动适度增加(≥ 相关死亡率。然而，纵向研究表明，在12-12个月中，锻炼参与度显著下降 每周15分钟)在临床上有意义地减少乳腺癌- 诊断后几个月，大多数乳腺癌幸存者从未完全恢复到诊断前的活动水平。 候选人提出了一种基于情感调节的创新方法来解决身体缺乏活动的问题，如 对乳腺癌存活率有负面影响的公共健康风险因素。培训和指导计划是 旨在提供以下方面的知识和技能：(1)早期干预开发；(2)密集纵向干预 数据收集和分析方法，(3)随机临床试验设计，(4)专业发展。这个 拟议的研究将完善一种受情绪调节的运动处方策略(Effect-Rx)，以便与身体一起使用 非活动性乳腺癌存活者(目标1)，概念验证测试影响-Rx对临床意义的影响 干预后中等强度体力活动参与，操作名称为≥ 每周90分钟 (目标2)、 以及量化情感因素和总体力活动之间的人内关联的强度(目的 3)。候选人将利用肥胖症建立的早期干预发展里程碑- 相关行为干预试验(Orbit) 两项研究。在这两项研究中，参与者的日常 指导要测试的方法和结果的模型 情感感受状态和体力活动将被测量 在基线和2周、6周和12周时使用生态瞬时评估(EMA)和加速度法- 向上。Effect-Rx策略将在研究1(N=20)中针对可接受性进行改进，并在#年进行测试(通过改进) 研究2(N=60)。在与她的导师和科学顾问团队协商后，候选人将使用 培训、研究成果和轨道干预发展框架，以系统指导 在这个基于影响的体力活动促进工作线的下一步，并提交她的第一个R01提案。

PROJECT SUMMARY/ABSTRACT The goal of this K08 Mentored Clinical Scientist Research Career Development Award is to prepare the candidate for an independent research career Breast cancer survivors who exercise regularly in behavioral oncology and health behavior intervention science. post-cancer diagnosis are less likely to die from cancer and even modest increases in physical activity (≥ related mortality. However, longitudinal studies show significant declines in exercise engagement during the 12- 15 minutes/week) yield clinically meaningful reductions in breast cancer- months post-diagnosis, with most breast cancer survivors never fully returning to pre-diagnosis activity levels. The candidate proposes an innovative approach, based on affect-regulation, to addressing physical inactivity as a public health risk factor negatively impacting breast cancer survivorship. The training and mentoring plan is designed to provide knowledge and skills in (1) early-phase intervention development, (2) intensive longitudinal data collection and analysis methods, (3) randomized clinical trial design, and (4) professional development. The proposed research will refine an affect-regulated exercise prescription strategy (Affect-Rx) for use with physically inactive breast cancer survivors (Aim 1), test for proof-of-concept the effect of Affect-Rx on clinically meaningful moderate-vigorous physical activity participation post-intervention, operationalized as ≥ 90 mins/week (Aim 2), and quantify the strength of within-person associations between affective factors and total physical activity (Aim 3). The candidate will use the milestones for early-phase intervention development established by the Obesity- Related Behavioral Intervention Trials (ORBIT) two studies. In both studies, participants’ daily Model to guide the methods and outcomes to be tested across affective feeling states and physical activity will be measured using ecological momentary assessment (EMA) and accelerometry at baseline and 2-, 6- and 12-weeks follow- up. The Affect-Rx strategy will be refined for acceptability in Study 1 (N = 20) and tested (with refinements) in Study 2 (N = 60). In consultation with her team of mentors and scientific advisors, the candidate will use the training, the results of the research, and the ORBIT intervention development framework to systematically guide the next steps in this affect-based physical activity promotion line of work and submit her first R01 proposal.