Increasing physical activity among breast cancer survivors: Use of the ORBIT Model to refine and test a novel approach to exercise promotion based on affect-regulation

增加乳腺癌幸存者的体力活动：使用 ORBIT 模型完善和测试基于情感调节的运动促进新方法

• 批准号: 10593920
• 负责人: Courtney Joyce Stevens
• 金额: $ 17.58万
• 依托单位: DARTMOUTH-HITCHCOCK CLINIC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10593920
• 关键词: Accelerometer; Address; Adherence; Adverse effects; Affect; Affective; Aftercare; American; Arousal; Award; Behavior; Behavior Therapy; Behavioral; Breast Cancer Risk Factor; Breast Cancer survivor; Breast Cancer survivorship; Cancer Survivor; Cancer Survivorship; Clinical; Clinical Trials Design; Consultations; Data; Data Analyses; Data Collection; Development; Diagnosis; Doctor of Philosophy; Ecological momentary assessment; Exercise; Fatigue; Feeling; General Population; Goals; Guidelines; Health Benefit; Health behavior; Individual; Intervention; Intervention Trial; Investigation; K-Series Research Career Programs; Knowledge; Light; Longitudinal Studies; Malignant Neoplasms; Measures; Medical center; Mentors; Methods; Modeling; Modification; Obesity; Oncology; Outcome; Participant; Persons; Phase; Phase Ib Trial; Physical Function; Physical activity; Positioning Attribute; Protocols documentation; Psychologist; Public Health; Randomized; Recommendation; Recurrent Malignant Neoplasm; Regulation; Research; Research Personnel; Risk Factors; Sampling; Science; Scientist; Sports Medicine; Strenuous Exercise; Structure; Surveys; Survivors; Testing; Time; Training; Treatment-Related Cancer; Variant; Work; adherence rate; arm; cancer diagnosis; cancer recurrence; career; career development; college; design; exercise prescription; exercise regimen; follow-up; health related quality of life; hedonic; improved; innovation; malignant breast neoplasm; method development; modifiable risk; mortality; motivated behavior; novel strategies; participant interview; patient oriented; physical conditioning; physical inactivity; pleasure; post intervention; preference; randomized, clinical trials; response; satisfaction; skills; standard of care; therapy development

PROJECT SUMMARY/ABSTRACT The goal of this K08 Mentored Clinical Scientist Research Career Development Award is to prepare the candidate for an independent research career Breast cancer survivors who exercise regularly in behavioral oncology and health behavior intervention science. post-cancer diagnosis are less likely to die from cancer and even modest increases in physical activity (≥ related mortality. However, longitudinal studies show significant declines in exercise engagement during the 12- 15 minutes/week) yield clinically meaningful reductions in breast cancer- months post-diagnosis, with most breast cancer survivors never fully returning to pre-diagnosis activity levels. The candidate proposes an innovative approach, based on affect-regulation, to addressing physical inactivity as a public health risk factor negatively impacting breast cancer survivorship. The training and mentoring plan is designed to provide knowledge and skills in (1) early-phase intervention development, (2) intensive longitudinal data collection and analysis methods, (3) randomized clinical trial design, and (4) professional development. The proposed research will refine an affect-regulated exercise prescription strategy (Affect-Rx) for use with physically inactive breast cancer survivors (Aim 1), test for proof-of-concept the effect of Affect-Rx on clinically meaningful moderate-vigorous physical activity participation post-intervention, operationalized as ≥ 90 mins/week (Aim 2), and quantify the strength of within-person associations between affective factors and total physical activity (Aim 3). The candidate will use the milestones for early-phase intervention development established by the Obesity- Related Behavioral Intervention Trials (ORBIT) two studies. In both studies, participants’ daily Model to guide the methods and outcomes to be tested across affective feeling states and physical activity will be measured using ecological momentary assessment (EMA) and accelerometry at baseline and 2-, 6- and 12-weeks follow- up. The Affect-Rx strategy will be refined for acceptability in Study 1 (N = 20) and tested (with refinements) in Study 2 (N = 60). In consultation with her team of mentors and scientific advisors, the candidate will use the training, the results of the research, and the ORBIT intervention development framework to systematically guide the next steps in this affect-based physical activity promotion line of work and submit her first R01 proposal.

项目摘要/摘要 这个K08指导的临床科学家研究职业发展奖的目标是准备 独立研究职业的候选人 定期运动的乳腺癌存活 在行为肿瘤学和健康行为干预科学中。 后癌后诊断不太可能死于癌症甚至 体育锻炼的适度增加（≥ 相关死亡率。但是，纵向研究表明，在12-- 15分钟/周）乳腺癌的临床有意义减少 - 诊断后几个月，大多数乳腺癌存活从未完全恢复到诊断前的活性水平。 候选人提出一种基于情感调节的创新方法，以将身体不活动解决为 公共卫生风险因素对乳腺癌生存产生负面影响。培训和心理计划是 旨在在（1）早期干预开发中提供知识和技能，（2）密集的纵向 数据收集和分析方法，（3）随机临床试验设计和（4）专业发展。这 拟议的研究将完善受情感调节的锻炼处方策略（altim-rx），以便在物理上使用 不活跃的乳腺癌存活（AIM 1），测试概念证明Action-RX对临床意义有意义的影响 干预后中度剧烈的体育活动参与，≥ 90分钟/周 （目标2）， 并量化情感因素与全部体育锻炼之间人际关系的强度（目标 3）。候选人将使用这些里程碑进行肥胖症建立的早期干预发展 - 相关行为干预试验（轨道） 两项研究。在这两项研究中，参与者的每日 指导要测试的方法和结果的模型 情感状态和体育锻炼将被衡量 使用生态瞬时评估（EMA）和基线和2个，6个和12周的加速度测定法 向上。 altimp-rx策略将在研究1（n = 20）中进行可接受性，并在 研究2（n = 60）。在与她的导师和科学顾问团队协商时，候选人将使用 培训，研究结果以及系统指导的轨道干预开发框架 基于影响的体育活动促进工作线的下一步，并提交了她的第一个R01提案。