Increasing physical activity among breast cancer survivors: Use of the ORBIT Model to refine and test a novel approach to exercise promotion based on affect-regulation

项目概要/摘要 这个K 08指导临床科学家研究职业发展奖的目标是准备 独立研究生涯的候选人 定期锻炼的乳腺癌幸存者 在行为肿瘤学和健康行为干预科学方面。 癌症后诊断不太可能死于癌症， 体力活动适度增加（≥ 相关死亡率。然而，纵向研究显示，在12- 18岁期间， 15分钟/周）产生临床上有意义的减少乳腺癌- 大多数乳腺癌幸存者从未完全恢复到诊断前的活动水平。 候选人提出了一种创新的方法，基于影响调节，以解决身体活动不足， 一个对乳腺癌生存率产生负面影响的公共卫生风险因素。培训和指导计划是 旨在提供以下方面的知识和技能：（1）早期干预发展，（2）密集的纵向 数据收集和分析方法，（3）随机临床试验设计，（4）专业发展。的 拟议的研究将完善一种受影响的运动处方策略（Affect-Rx）， 非活动性乳腺癌幸存者（目标1），检测Affect-Rx对临床有意义的 干预后参与中度-剧烈体力活动，操作为≥ 90分钟/周 (Aim 2）、 并量化情感因素和总体力活动之间的人内关联强度（目的 3）。候选人将使用肥胖协会建立的早期干预开发里程碑- 相关行为干预试验（ORBIT） 两项研究。在这两项研究中，参与者每天 模型，以指导方法和结果进行测试， 将测量情感状态和身体活动 在基线和2周、6周和12周后使用生态瞬时评估（EMA）和加速度计- 起来将在研究1（N = 20）中对Affect-Rx策略的可接受性进行细化，并在 研究2（N = 60）。在与她的导师和科学顾问团队协商后，候选人将使用 培训、研究成果和ORBIT干预开发框架， 在这个基于影响的身体活动促进工作线的下一步，并提交她的第一个R 01提案。

PROJECT SUMMARY/ABSTRACT The goal of this K08 Mentored Clinical Scientist Research Career Development Award is to prepare the candidate for an independent research career Breast cancer survivors who exercise regularly in behavioral oncology and health behavior intervention science. post-cancer diagnosis are less likely to die from cancer and even modest increases in physical activity (≥ related mortality. However, longitudinal studies show significant declines in exercise engagement during the 12- 15 minutes/week) yield clinically meaningful reductions in breast cancer- months post-diagnosis, with most breast cancer survivors never fully returning to pre-diagnosis activity levels. The candidate proposes an innovative approach, based on affect-regulation, to addressing physical inactivity as a public health risk factor negatively impacting breast cancer survivorship. The training and mentoring plan is designed to provide knowledge and skills in (1) early-phase intervention development, (2) intensive longitudinal data collection and analysis methods, (3) randomized clinical trial design, and (4) professional development. The proposed research will refine an affect-regulated exercise prescription strategy (Affect-Rx) for use with physically inactive breast cancer survivors (Aim 1), test for proof-of-concept the effect of Affect-Rx on clinically meaningful moderate-vigorous physical activity participation post-intervention, operationalized as ≥ 90 mins/week (Aim 2), and quantify the strength of within-person associations between affective factors and total physical activity (Aim 3). The candidate will use the milestones for early-phase intervention development established by the Obesity- Related Behavioral Intervention Trials (ORBIT) two studies. In both studies, participants’ daily Model to guide the methods and outcomes to be tested across affective feeling states and physical activity will be measured using ecological momentary assessment (EMA) and accelerometry at baseline and 2-, 6- and 12-weeks follow- up. The Affect-Rx strategy will be refined for acceptability in Study 1 (N = 20) and tested (with refinements) in Study 2 (N = 60). In consultation with her team of mentors and scientific advisors, the candidate will use the training, the results of the research, and the ORBIT intervention development framework to systematically guide the next steps in this affect-based physical activity promotion line of work and submit her first R01 proposal.