LEAP Administrative Core

1. 摘要 “早期精神病实验室”中心（又名 LEAP）的行政核心将支持创建 一个研究联盟的成员，该联盟涵盖马萨诸塞州和美国三个主要的首发精神病诊所 组建由领先研究人员组成的跨学科团队。 LEAP 中心致力于 T2 转化 首发精神病的研究，包括分析专业护理、广泛的多模式的影响 纵向数据收集、预测和比较有效性研究，以更好地理解 患者结果和治疗效果的异质性。行政核心将服务于中心的目标 通过促进定期沟通、促进学科之间的协同作用、支持培训机会 和试点项目，传播有关中心活动的信息，组织利益相关者小组，以及 监督对中心本身的评估。核心将由中心领导博士领导。翁古尔、许和 埃尔南，并得到中心管理员的支持。核心有四个目标。首先，它将监督和协调 对中心运作至关重要的所有活动，包括维护监管和合同 义务、预算和分包合同的管理、与学术、州和联邦机构的互动， 完成报告要求，支持中心各部门之间的定期沟通，以及 促进和跟踪合作。其次，核心将监督和协调治理结构 包括指导委员会、手稿委员会、数据管理和访问委员会、试点项目委员会和培训委员会 中心内。第三，它将管理行为的征集、审查、资助、监控和报告 每年平均有两个R03级试点项目。第四，行政核心将协调和 管理与不同利益相关者的参与，包括患者和家庭团体、国家和 国家政策制定者、付款人以及高级科学专家小组。核心还将支持 通过会议和短期课程、访问学者系列传播中心的活动和进展， 临床病例会议、协议和软件，以及旨在为公众服务的网站。 最后，行政核心将跟踪中心绩效的客观指标并召开年度会议 咨询委员会会议（由精神病学研究内外的高级研究人员组成） 将对中心进展进行评估并提出改进建议）并定期召开会议 该中心的教师小组和利益相关者委员会的会议。总而言之，核心活动是 旨在确保 LEAP 中心成为一个大于各个部分之和的统一整体。

1. Abstract The Administrative Core for the “Laboratory in Early Psychosis” Center, a.k.a. LEAP, will support the creation of a research consortium spanning three major first episode psychosis clinics in Massachusetts and the formation of a transdisciplinary team of leading researchers. The LEAP Center is dedicated to T2 translational research in first episode psychosis, including analysis of the impact of specialized care, extensive multimodal longitudinal data collection, and prediction and comparative effectiveness research to better understand heterogeneity in patient outcomes and treatment effects. The Administrative Core will serve the Center’s goals by facilitating regular communication, fostering synergy among disciplines, supporting training opportunities and pilot projects, disseminating information on Center activities, organizing stakeholder panels, and overseeing evaluation of the Center itself. The Core will be led by the Center Leads Drs. Öngür, Hsu, and Hernan, and supported by a Center Administrator. The Core has four aims. First, it will oversee and coordinate all activities essential to the functioning of the Center, including maintenance of regulatory and contractual obligations, management of budgets and subcontracts, interacting with academic, state, and federal agencies, completion of reporting requirements, supporting regular communication between Center elements, and fostering and tracking collaborations. Second, the Core will oversee and coordinate governance structures including the Steering, Manuscript, Data Management and Access, Pilot Project, and Training committees within the Center. Third, it will manage the solicitation, review, funding, monitoring, and reporting of the conduct of an average of two R03-level pilot projects each year. And fourth, the Administrative Core will coordinate and manage engagement with a diverse array of stakeholders including patient and family groups, national and state policy makers, payers, as well as a panel of senior scientific experts. The Core will also support dissemination of Center activities and advances through conferences and short courses, visiting scholar series, clinical case conferences, protocols and software, as well as a website intended to serve the general public. Finally, the Administrative Core will track objective metrics of Center performance and convene annual meetings of the Advisory Board (composed of senior investigators within and outside of psychiatry research which will conduct assessments of Center progress and suggest refinements) as well as convene regular meetings of the Center’s Faculty Panel, and Stakeholder Committees. Taken together, the Core activities are designed to ensure that the LEAP Center becomes a unified whole that is greater than the sum of its parts.