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Research and Mentoring on Brain and Peripheral Bioenergetics in Schizophrenia

精神分裂症大脑和周围生物能量学的研究和指导

基本信息

批准号：
9763643
负责人：
Dost Ongur
金额：
$ 15.77万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-01 至 2020-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9763643
关键词：
ATP Synthesis Pathway Antipsychotic Agents Applications Grants Area Award Bioenergetics Bipolar Disorder Brain Brain imaging Caliber Clinical Clinical Investigator Clinical Research Data Development Diabetes Mellitus Educational process of instructing Ensure Environment Excess Mortality Exercise Faculty First Degree Relative Functional disorder Funding Future Genetic Glutamates Goals Grant Hospitals Individual Insulin Resistance Intervention Lead Link Lipids Literature Magnetic Resonance Spectroscopy Measures Mentors Mentorship Metabolic Metabolic syndrome Metabolism Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Mitochondria Motivation Muscle National Institute of Mental Health Neurobiology Participant Patients Peripheral Pharmaceutical Preparations Phosphorus Photic Stimulation Process Production Productivity Protons Psychiatrist Psychotic Disorders Public Health Research Research Activity Research Personnel Research Proposals Research Training Resources Rest Role Rotation Schizophrenia Scientist Series Severities Soleus Muscle Techniques Time Training United States National Institutes of Health Visual Cortex Work Writing base brain abnormalities brain metabolism career career development cohort design first episode schizophrenia gamma-Aminobutyric Acid glucose metabolism in vivo information processing interest knowledge base meetings muscle metabolism neuroimaging neurotransmission next generation novel patient oriented research programs public health relevance recruit severe psychiatric disorder skills success therapeutic target tool white matter

项目摘要

DESCRIPTION (provided by applicant): This is an application for a K24 Midcareer Investigator in Patient Oriented Research award. I am a psychiatrist with clinical expertise in psychotic disorders and background in neurobiology. I have been conducting noninvasive neuroimaging studies probing cellular abnormalities in schizophrenia and bipolar disorder. I have built a group of junior investigators engaged in patient oriented research and I am the Chief of the Psychotic Disorders Division at McLean Hospital. However, I have a need for protected time to enhance my mentoring activities and to develop new areas of expertise to meet my long-term career goals of identifying therapeutic targets in psychotic disorders and to train the next generation of investigators in this field. In this proposal, I outline a mentoring lan for recruiting and retaining high caliber junior investigators into my research group. In addition,I will obtain additional training in mitochondrial function, brain bioenergetics, and peripheral glucose metabolism/diabetes. My research to date has examined abnormalities in glutamatergic and GABAergic neurotransmission. I will use this training to expand my studies into 31P magnetic resonance spectroscopy which provides detailed information about ATP synthesis and metabolism - processes which are intricately linked with neurotransmission. There are multiple indications that brain metabolism is also related to peripheral metabolism. Since patients with psychotic disorders are also prone to the metabolic syndrome, I will also initiate a new series of studies on muscle metabolism and peripheral markers of insulin resistance. I predict that these measures will correlate with brain measures, and they will suggest potential new opportunities for treating schizophrenia - an area of great unmet need.

描述（由申请人提供）：这是一份 K24 职业生涯中期研究员以患者为导向的研究奖的申请。我是一名精神科医生，拥有精神病方面的临床专业知识和神经生物学背景。我一直在进行无创神经影像学研究，探讨精神分裂症和双相情感障碍的细胞异常。我组建了一批初级研究人员，从事以患者为导向的研究，我是麦克莱恩医院精神障碍科的主任。然而，我需要有受保护的时间来加强我的指导活动并开发新的专业领域，以实现我的长期职业目标，即确定精神障碍的治疗目标并培训该领域的下一代研究人员。在这份提案中，我概述了一个指导网络，用于招募和留住高素质的初级研究人员进入我的研究小组。此外，我还将获得线粒体功能、大脑生物能量学和外周葡萄糖代谢/糖尿病方面的额外培训。迄今为止，我的研究已经检查了谷氨酸能和 GABA 能神经传递的异常。我将利用这次培训将我的研究扩展到 31P 磁共振波谱，它提供有关 ATP 合成和代谢（与神经传递错综复杂的过程）的详细信息。有多种迹象表明大脑代谢也与外周代谢有关。由于精神病患者也容易出现代谢综合征，因此我还将启动一系列关于肌肉代谢和胰岛素抵抗外周标志物的新系列研究。我预测这些措施将与大脑测量相关，并且它们将为治疗精神分裂症（一个需求未得到满足的领域）提供潜在的新机会。