Research and Mentoring on Brain and Peripheral Bioenergetics in Schizophrenia
精神分裂症大脑和周围生物能量学的研究和指导
基本信息
- 批准号:9763643
- 负责人:
- 金额:$ 15.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-08-01 至 2020-07-31
- 项目状态:已结题
- 来源:
- 关键词:ATP Synthesis PathwayAntipsychotic AgentsApplications GrantsAreaAwardBioenergeticsBipolar DisorderBrainBrain imagingCaliberClinicalClinical InvestigatorClinical ResearchDataDevelopmentDiabetes MellitusEducational process of instructingEnsureEnvironmentExcess MortalityExerciseFacultyFirst Degree RelativeFunctional disorderFundingFutureGeneticGlutamatesGoalsGrantHospitalsIndividualInsulin ResistanceInterventionLeadLinkLipidsLiteratureMagnetic Resonance SpectroscopyMeasuresMentorsMentorshipMetabolicMetabolic syndromeMetabolismMid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented ResearchMitochondriaMotivationMuscleNational Institute of Mental HealthNeurobiologyParticipantPatientsPeripheralPharmaceutical PreparationsPhosphorusPhotic StimulationProcessProductionProductivityProtonsPsychiatristPsychotic DisordersPublic HealthResearchResearch ActivityResearch PersonnelResearch ProposalsResearch TrainingResourcesRestRoleRotationSchizophreniaScientistSeriesSeveritiesSoleus MuscleTechniquesTimeTrainingUnited States National Institutes of HealthVisual CortexWorkWritingbasebrain abnormalitiesbrain metabolismcareercareer developmentcohortdesignfirst episode schizophreniagamma-Aminobutyric Acidglucose metabolismin vivoinformation processinginterestknowledge basemeetingsmuscle metabolismneuroimagingneurotransmissionnext generationnovelpatient oriented researchprogramspublic health relevancerecruitsevere psychiatric disorderskillssuccesstherapeutic targettoolwhite matter
项目摘要
DESCRIPTION (provided by applicant): This is an application for a K24 Midcareer Investigator in Patient Oriented Research award. I am a psychiatrist with clinical expertise in psychotic disorders and background in neurobiology. I have been conducting noninvasive neuroimaging studies probing cellular abnormalities in schizophrenia and bipolar disorder. I have built a group of junior investigators engaged in patient oriented research and I am the Chief of the Psychotic Disorders Division at McLean Hospital. However, I have a need for protected time to enhance my mentoring activities and to develop new areas of expertise to meet my long-term career goals of identifying therapeutic targets in psychotic disorders and to train the next generation of investigators in this field. In this proposal, I outline a mentoring lan for recruiting and retaining high caliber junior investigators into my research group. In addition,I will obtain additional training in mitochondrial function, brain bioenergetics, and peripheral glucose metabolism/diabetes. My research to date has examined abnormalities in glutamatergic and GABAergic neurotransmission. I will use this training to expand my studies into 31P magnetic resonance spectroscopy which provides detailed information about ATP synthesis and metabolism - processes which are intricately linked with neurotransmission. There are multiple indications that brain metabolism is also related to peripheral metabolism. Since patients with psychotic disorders are also prone to the metabolic syndrome, I will also initiate a new series of studies on muscle metabolism and peripheral markers of insulin resistance. I predict that these measures will correlate with brain measures, and they will suggest potential new opportunities for treating schizophrenia - an area of great unmet need.
项目成果
期刊论文数量(14)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Development of novel behavioral interventions in an experimental therapeutics world: Challenges, and directions for the future.
实验治疗领域新型行为干预的发展:挑战和未来方向。
- DOI:10.1016/j.schres.2017.06.010
- 发表时间:2018
- 期刊:
- 影响因子:4.5
- 作者:Lewandowski,KathrynE;Ongur,Dost;Keshavan,MatcheriS
- 通讯作者:Keshavan,MatcheriS
The structural basis for interhemispheric functional connectivity: Evidence from individuals with agenesis of the corpus callosum.
- DOI:10.1016/j.nicl.2020.102425
- 发表时间:2020
- 期刊:
- 影响因子:0
- 作者:Yuan J;Song X;Kuan E;Wang S;Zuo L;Ongur D;Hu W;Du F
- 通讯作者:Du F
Cognitive and clinical predictors of community functioning across the psychoses.
精神病社区功能的认知和临床预测因素。
- DOI:10.1002/pchj.356
- 发表时间:2020
- 期刊:
- 影响因子:1.6
- 作者:Lewandowski,KathrynE;Cohen,TaliaR;Ongur,Dost
- 通讯作者:Ongur,Dost
Past due: improving the naming of psychiatric disorders.
逾期:改进精神疾病的命名。
- DOI:10.1016/s2215-0366(21)00478-8
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Cohen,BruceM;Öngür,Dost;Harris,PeterQ
- 通讯作者:Harris,PeterQ
N-acetylaspartate concentration in psychotic disorders: T2-relaxation effects.
- DOI:10.1016/j.schres.2021.04.012
- 发表时间:2021-06
- 期刊:
- 影响因子:4.5
- 作者:Kuan E;Chen X;Du F;Ongur D
- 通讯作者:Ongur D
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Dost Ongur其他文献
Dost Ongur的其他文献
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{{ truncateString('Dost Ongur', 18)}}的其他基金
American Psychopathological Association 2023 Annual Meeting
美国精神病理学协会2023年年会
- 批准号:
10682780 - 财政年份:2023
- 资助金额:
$ 15.77万 - 项目类别:
Randomized controlled trial of enhanced coordinated specialty care (CSC 2.0)
增强协调专业护理的随机对照试验(CSC 2.0)
- 批准号:
10623805 - 财政年份:2019
- 资助金额:
$ 15.77万 - 项目类别:
Research and Mentoring on Brain and Peripheral Bioenergetics in Schizophrenia
精神分裂症大脑和周围生物能量学的研究和指导
- 批准号:
8890959 - 财政年份:2015
- 资助金额:
$ 15.77万 - 项目类别:
Research and Mentoring on Brain and Peripheral Bioenergetics in Schizophrenia
精神分裂症大脑和周围生物能量学的研究和指导
- 批准号:
9320660 - 财政年份:2015
- 资助金额:
$ 15.77万 - 项目类别:
An MRI based in vivo measure of glutamatergic synaptic neurotransmission
基于 MRI 的谷氨酸突触神经传递体内测量
- 批准号:
8797971 - 财政年份:2014
- 资助金额:
$ 15.77万 - 项目类别:
An MRI based in vivo measure of glutamatergic synaptic neurotransmission
基于 MRI 的谷氨酸突触神经传递体内测量
- 批准号:
8925157 - 财政年份:2014
- 资助金额:
$ 15.77万 - 项目类别:
An MRI based in vivo measure of glutamatergic synaptic neurotransmission
基于 MRI 的谷氨酸突触神经传递体内测量
- 批准号:
9130268 - 财政年份:2014
- 资助金额:
$ 15.77万 - 项目类别:
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