LEAP Administrative Core

摘要 “早期精神病实验室”中心的管理核心，又名。Leap Center，将支持 继续开展现有中心的活动。这涉及到第一集的研究联盟 马萨诸塞州的精神病诊所和一个由领先研究人员组成的跨学科团队。LEAP中心是 致力于研究首发精神病，包括在我们的联盟中测试干预策略 临床随机对照试验，广泛的多模式纵向数据收集，并预测和 使用不同临床数据集的比较有效性研究，以更好地了解 患者结局和治疗影响。行政核心将服务于中心的目标，通过促进 定期沟通，促进学科之间的协同，支持培训机会和试点 项目，传播中心活动的信息，组织利益相关者小组，并监督 对中心本身的评价。核心将由中心领导Onngür、Hsu和Hernan博士领导，以及 由中心管理员提供支持。它将被安置在麦克莱恩医院的专用办公空间内。《核心》 有四个目标。首先，它将监督和协调中心运作所必需的所有活动， 包括维持规章和合同义务、管理预算和分包合同， 与学术、州和联邦机构互动，完成报告要求，支持 中心成员之间的定期沟通，并促进和跟踪协作。第二，核心 将监督和协调治理结构，包括指导、手稿、数据管理和 中心内的准入、试点项目和培训委员会。第三，它将管理征集，审查， 平均每年资助、监测和报告两个R03级试点项目的实施情况。和 第四，行政核心将协调和管理与各种利益攸关方的接触 包括患者和家庭团体，国家和州政策制定者，付款人以及一个高级专家小组 科学专家。该中心还将通过以下方式支持中心活动和进展的传播 会议和短期课程，访问学者系列，临床病例会议，以及网站。最后， 行政核心将跟踪中心业绩的客观指标，并召开中心年度会议 咨询委员会(由精神病学研究内外的高级调查人员组成，将进行 对中心进展的评估并提出改进建议)。总而言之，核心活动旨在 确保LEAP中心保持一个统一的整体，大于其各部分的总和。

Abstract The Administrative Core for the “Laboratory in Early Psychosis” Center, a.k.a. LEAP Center, will support continued activities of the currently existing Center. This involves the research consortium of first episode psychosis clinics in Massachusetts and an interdisciplinary team of leading researchers. The LEAP Center is dedicated to research in first episode psychosis, including testing an intervention strategy in our consortium of clinics in a randomized controlled trial, extensive multimodal longitudinal data collection, and prediction and comparative effectiveness research using various clinical datasets to better understand heterogeneity in patient outcomes and treatment impacts. The Administrative Core will serve the Center’s goals by facilitating regular communication, fostering synergy among disciplines, supporting training opportunities and pilot projects, disseminating information on Center activities, organizing stakeholder panels, and overseeing evaluation of the Center itself. The Core will be led by the Center Leads Drs. Öngür, Hsu, and Hernan, and supported by a Center Administrator. It will be housed in dedicated office space at McLean Hospital. The Core has four aims. First, it will oversee and coordinate all activities essential to the functioning of the Center, including maintenance of regulatory and contractual obligations, management of budgets and subcontracts, interacting with academic, state, and federal agencies, completion of reporting requirements, supporting regular communication between Center elements, and fostering and tracking collaborations. Second, the Core will oversee and coordinate governance structures including the Steering, Manuscript, Data Management and Access, Pilot Project, and Training committees within the Center. Third, it will manage the solicitation, review, funding, monitoring, and reporting of the conduct of an average of two R03-level pilot projects each year. And fourth, the Administrative Core will coordinate and manage engagement with a diverse array of stakeholders including patient and family groups, national and state policy makers, payers, as well as a panel of senior scientific experts. The Core will also support dissemination of Center activities and advances through conferences and short courses, visiting scholar series, clinical case conferences, as well as a website. Finally, the Administrative Core will track objective metrics of Center performance and convene annual meetings of the Advisory Board (composed of senior investigators within and outside of psychiatry research which will conduct assessments of Center progress and suggest refinements). Taken together, the Core activities are designed to ensure that the LEAP Center remains a unified whole that is greater than the sum of its parts.