American Psychopathological Association 2023 Annual Meeting

项目总结/摘要 此申请要求R13资金用于2023年美国精神病理学协会会议 （APPA）的主题是“精神病理学的复杂性：一种尺寸不适合所有人”。这个话题很及时，因为 越来越多的人认识到，复杂性和异质性可能是最重要的挑战， 精神疾病的病因、预防和治疗研究进展，包括药物使用 紊乱我们将探索几种研究途径，以识别和拥抱复杂性的来源， 研究作为一个机会，以更好地解决精神病理学在临床和人口为基础的样本。 自1910年成立以来，APPA的使命是：（1）支持对精神障碍的调查 和行为，包括其生物基础和心理社会基础，（2）促进 培养青年科学家。APPA每年举行一次年会，重点讨论不同的主题。 演讲者和与会者在学科和专业领域方面广泛多样。独一无二的一切-- APPA会议的全体会议形式促进了信息，概念，方法，新发现， 当前的争议，以及由演讲者的多样性所促进的知识方面的紧迫差距， 观众2023年会议的目的是以这种独特的形式提供令人兴奋的科学会议 通过刺激新的研究方向，合作和影响该领域的目标-对于初级 科学家和来自代表性不足群体的个人-新的联系和职业机会。 会议主持人包括各自领域的杰出领导人（例如，NIH研究所代表， 大学系主任、中心主任和精神病学、心理学、流行病学的调查人员， 遗传学和神经科学）和有潜力领导下一代的初级科学家。专题介绍 包括：主题演讲“个性化医疗”和“理解精神疾病的复杂性” 和关于“数据：了解和处理信号和噪声的可变性来源”、“发展： 同型连续性还是多能综合征？“诊断：过度特异性和特异性不足”;“ 治疗反应-它是什么，我们如何从中学习？";和“生物学：可变模式，没有映射 从生物学到精神病理学，这是怎么回事？”许多活动是专门为青少年设计的 科学家（学生，研究员，早期职业调查员），包括一个研讨会，早餐圆桌会议与高级 科学家，口头海报介绍给整个APPA观众，并指导更多的初级与会者 APPA理事会成员和研究员。所需资金主要用于提供以下效益的赔偿金： 2023年APPA出席初级科学家和来自代表性不足群体的调查人员，他们将 否则不能参加会议。这样的出席旨在吸引初级科学家， 成为下一代研究人员和代表性不足的群体的成员， 参与我们领域的研究。要求提供额外资金，以支付会议的一些服务费用。

PROJECT SUMMARY/ABSTRACT This application requests R13 funds for the 2023 conference of the American Psychopathological Association (APPA) on the topic “Complexity in Psychopathology: One Size Does Not Fit All.” This topic is timely because of the growing recognition that complexity and heterogeneity are perhaps the most important challenges to progress in research into causes, prevention, and treatment of psychiatric conditions, including substance use disorders. We will explore several avenues of research for identifying and embracing sources of complexity in research as an opportunity to better address psychopathology in both clinical and population-based samples. The mission of APPA, since its founding in 1910, has been to (1) support the investigation of disorders of mind and behavior, including their biological underpinnings and psychosocial substrates, and (2) promote the development of junior scientists. The APPA holds an annual meeting focused on a different topic each year. Presenters and attendees are widely diverse in terms of discipline and area of expertise. The unique all- plenary format of the APPA meeting stimulates an exchange of information, concepts, methods, new findings, current controversies, and pressing gaps in knowledge that is facilitated by the diversity of the presenters and the audience. The aim of the 2023 conference is to provide an exciting scientific meeting in this unique format with the goal of impacting the field by stimulating new research directions, collaborations, and – for junior scientists and individuals from underrepresented groups – new connections and career opportunities. Conference presenters include distinguished leaders in their fields (e.g., NIH institute representatives, university department chairs, center directors, and investigators in psychiatry, psychology, epidemiology, genetics, and neuroscience) and junior scientists with potential to lead the next generation. Presentation topics include: keynote lectures on “Personalized medicine” and “Making sense of complexity in psychiatric disorders” and panels on “Data: Understanding and handling sources of variability in signal and noise”; “Development: Homotypic continuity or pluripotent syndromes?”; “Diagnosis: Over- and under-specificity”; “Heterogeneity of treatment response – what is it and how can we learn from it?”; and “Biology: Variable patterns, no mapping from biology onto psychopathology… what is going on?” Many activities are designed specifically for junior scientists (students, fellows, early-career investigators), including a workshop, breakfast roundtable with senior scientists, oral poster presentations to the entire APPA audience, and mentorship of more junior attendees by APPA Council members and Fellows. Funds are requested primarily for awards that will provide the benefits of 2023 APPA attendance to junior scientists and to investigators from underrepresented groups who would otherwise not be able to participate in the meeting. Such attendance is designed to attract junior scientists to become members of the next generation of researchers and members of underrepresented groups to become involved in research in our field. Additional funds are requested to cover some service costs for the meeting.