Technology to Realize the Full Potential of UHF MRI
充分发挥 UHF MRI 潜力的技术
基本信息
- 批准号:10376730
- 负责人:
- 金额:$ 120.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-02-01 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAddressAdvanced DevelopmentAlgorithmsAnimal ModelBasic ScienceBehaviorBiochemicalBiomedical ResearchBiotechnologyBrainClinicalClinical ResearchCognitive ScienceDataData SetDevelopmentDisease ProgressionEngineeringEnvironmentFunctional Magnetic Resonance ImagingFutureGoalsHeadHeatingHumanImageImaging DeviceImaging technologyImplantIndividualJointsMacacaMagnetic ResonanceMagnetic Resonance ImagingMalignant NeoplasmsMeasuresMetabolicMethodsModelingMolecular ProbesMonitorMorphologic artifactsMotionMultimodal ImagingMusculoskeletal DiseasesNeuronsNeurosciencesNoisePhysicsPhysiologicalPopulationResearchResolutionResourcesRunningSafetySchemeSiteSpatial DistributionSpectrum AnalysisSynapsesSystemTechniquesTechnologyTemperatureTimeTissuesTranslational ResearchVariantWorkbasedesignhigh resolution imagingimage reconstructionimaging approachimaging modalityimaging platformimaging studyimaging systemimprovedin vivoinnovationinsightinstrumentationmagnetic fieldmolecular dynamicsmolecular imagingmultidimensional datamultiphoton imagingnervous system disordernovelnovel strategiesoptical imagingparametric imagingradio frequencyreconstructionresearch and developmentsenescencesensorsimulationspatiotemporalspectroscopic imagingtechnology research and developmenttooltreatment response
项目摘要
OVERALL ABSTRACT
The Center for Magnetic Resonance Research (CMRR) has pioneered many of the MR methods that are critical
in contemporary biomedical research including (but not limited to) the introduction of UHF instrumentation and
accompanying techniques that overcome its challenges, accelerated MR imaging approaches, and many of the
methods used to obtain biochemical information in vivo using spectroscopy and multinuclear capabilities. To
continue the tradition of innovation, the long term goal of this Center proposal is to establish a national resource
for enabling ultrahigh field (UHF, mostly 7T and above), magnetic resonance imaging (MRI) technologies to
advance biomedical research and discovery. Towards building this P41 center, several technical research and
development (TRD) projects are proposed that will work synergistically to realize the potential of our unique
imaging resources. TRD1 involves the development of a multimodal imaging platform allowing simultaneous
optical imaging, an invasive technology capable of visualizing neuronal activity at the single neuron and synapse
level, with non-invasive MRI methods which provide high resolution functional MRI and connectivity data over
the entire brain but at a coarser spatiotemporal resolution. This platform will provide unprecedented opportunities
for detailed studies of brain function underlying behavior and inform future human studies using MRI alone. TRD2
focuses on establishing a sensitive molecular imaging platform combining novel systems solutions and advanced
strategies to perform multinuclear MRI spectroscopy and imaging studies. This system will provide unparalleled
sensitivity to probe molecular parameters to characterize tissue through molecular dynamics, spatial distributions
of functional metabolic parameters and advanced multinuclear studies. TRD3 develops reconstruction strategies
supporting highly accelerated high-resolution imaging approaches while incorporating methods to reduce the
impact of physiologic motion and noise. These reconstruction methods advance the field by overcoming what
otherwise would be limiting factors with respect to achievable temporal and spatial resolutions. TRD4 provides
critical engineering solutions addressing both 1) radiofrequency (RF) coil (i.e. antennae) designs and safety for
sensitive high resolution imaging at UHF without which the systems conceived of in TRD1 and TRD2 could not
be realized and 2) methods to image around implants by minimizing heating and artifacts which if not addressed
would limit the access of the UHF imaging to a large section of the population. As described, these projects can
tackle the fundamental challenges of UHF. Only when these challenges are addressed can we develop the new
approaches to truly advance basic and clinical translational research. In fact it is exactly this cycle of development
and discovery that inspired, then justified, the spending of time and resources to develop, build and site the
10.5T system at our center. While the 10.5T scanner is at the center of the proposed developments, the impact
of this Center on biomedical research will extend 7T and below as well as to fields beyond MRI (cognitive science,
neuroscience, senescence, musculoskeletal disorders, neurological disorder, cancer among others).
总体摘要
磁共振研究中心(CMRR)开创了许多至关重要的MR方法
在当代生物医学研究中,包括(但不限于)UHF仪器的引入,
伴随的技术,克服了它的挑战,加速MR成像方法,以及许多
使用光谱学和多核能力获得体内生化信息的方法。到
继续创新的传统,本中心提案的长期目标是建立一个国家资源
为了使超高频(UHF,主要是7T及以上),磁共振成像(MRI)技术,
推进生物医学研究和发现。为了建立这个P41中心,一些技术研究和
提出了将协同工作,以实现我们独特的
图像资源。TRD 1涉及多模式成像平台的开发,
光学成像,一种能够可视化单个神经元和突触的神经元活动的侵入性技术
水平,与非侵入性MRI方法,提供高分辨率的功能性MRI和连接数据,
整个大脑,但在一个粗糙的时空分辨率。这个平台将提供前所未有的机会
用于详细研究大脑功能潜在的行为,并为未来单独使用MRI的人类研究提供信息。TRD 2
专注于建立一个灵敏的分子成像平台,结合新颖的系统解决方案和先进的
策略进行多核MRI光谱和成像研究。该系统将提供无与伦比的
通过分子动力学、空间分布和分子动力学来表征组织的探针分子参数的灵敏度
功能代谢参数和先进的多核研究。TRD 3制定重建战略
支持高度加速的高分辨率成像方法,同时结合减少
生理运动和噪声的影响。这些重建方法通过克服
否则将是关于可实现的时间和空间分辨率的限制因素。TRD 4提供
关键工程解决方案,解决1)射频(RF)线圈(即天线)设计和安全性,
在超高频下进行灵敏的高分辨率成像,如果没有这些成像,TRD 1和TRD 2中设想的系统就不能
2)通过最小化加热和伪影(如果不解决)来在植入物周围成像的方法
这将限制超高频成像对大部分人口的访问。如上所述,这些项目可以
应对UHF的根本挑战。只有应对这些挑战,我们才能发展新的
真正推进基础和临床转化研究的方法。事实上正是这种发展的循环
和发现,激发,然后证明,花费时间和资源来开发,建设和网站,
10.5T系统在我们的中心。虽然10.5T扫描仪是拟议开发的中心,但其影响
该中心的生物医学研究将扩展到7T及以下以及MRI(认知科学,
神经科学、衰老、肌肉骨骼疾病、神经系统疾病、癌症等)。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Gregory John Metzger其他文献
Gregory John Metzger的其他文献
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{{ truncateString('Gregory John Metzger', 18)}}的其他基金
Development of Enabling Technologies for Clinical Ultrahigh Field Body MRI
临床超高场体 MRI 使能技术的开发
- 批准号:
10391523 - 财政年份:2021
- 资助金额:
$ 120.32万 - 项目类别:
Computer Aided Diagnostic System for Prostate Cancer Detection Using Quantitative Multiparametric MRI
使用定量多参数 MRI 检测前列腺癌的计算机辅助诊断系统
- 批准号:
10493089 - 财政年份:2021
- 资助金额:
$ 120.32万 - 项目类别:
Development of Enabling Technologies for Clinical Ultrahigh Field Body MRI
临床超高场体 MRI 使能技术的开发
- 批准号:
10533352 - 财政年份:2021
- 资助金额:
$ 120.32万 - 项目类别:
Computer Aided Diagnostic System for Prostate Cancer Detection Using Quantitative Multiparametric MRI
使用定量多参数 MRI 检测前列腺癌的计算机辅助诊断系统
- 批准号:
10705180 - 财政年份:2021
- 资助金额:
$ 120.32万 - 项目类别:
Development of Enabling Technologies for Clinical Ultrahigh Field Body MRI
临床超高场体 MRI 使能技术的开发
- 批准号:
10210905 - 财政年份:2021
- 资助金额:
$ 120.32万 - 项目类别:
Technology to Realize the Full Potential of UHF MRI (Supplement)
充分发挥 UHF MRI 潜力的技术(补充)
- 批准号:
10285102 - 财政年份:2019
- 资助金额:
$ 120.32万 - 项目类别:
Technology to Realize the Full Potential of UHF MRI
充分发挥 UHF MRI 潜力的技术
- 批准号:
10549850 - 财政年份:2019
- 资助金额:
$ 120.32万 - 项目类别:
TRD2 - Ultrahigh Field Molecular Imaging and Spectroscopy
TRD2 - 超高场分子成像和光谱
- 批准号:
10376733 - 财政年份:2019
- 资助金额:
$ 120.32万 - 项目类别:
TRD2 - Ultrahigh Field Molecular Imaging and Spectroscopy
TRD2 - 超高场分子成像和光谱
- 批准号:
10549854 - 财政年份:2019
- 资助金额:
$ 120.32万 - 项目类别:
Development of an Optimal MRI Platform for Prostate Investigations at 7 Tesla
开发用于 7 特斯拉前列腺研究的最佳 MRI 平台
- 批准号:
8234736 - 财政年份:2012
- 资助金额:
$ 120.32万 - 项目类别:
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