Technology to Realize the Full Potential of UHF MRI

充分发挥 UHF MRI 潜力的技术

• 批准号: 10376730
• 负责人: Gregory John Metzger
• 金额: $ 120.32万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10376730
• 关键词: 3-Dimensional; Address; Advanced Development; Algorithms; Animal Model; Basic Science; Behavior; Biochemical; Biomedical Research; Biotechnology; Brain; Clinical; Clinical Research; Cognitive Science; Data; Data Set; Development; Disease Progression; Engineering; Environment; Functional Magnetic Resonance Imaging; Future; Goals; Head; Heating; Human; Image; Imaging Device; Imaging technology; Implant; Individual; Joints; Macaca; Magnetic Resonance; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Metabolic; Methods; Modeling; Molecular Probes; Monitor; Morphologic artifacts; Motion; Multimodal Imaging; Musculoskeletal Diseases; Neurons; Neurosciences; Noise; Physics; Physiological; Population; Research; Resolution; Resources; Running; Safety; Scheme; Site; Spatial Distribution; Spectrum Analysis; Synapses; System; Techniques; Technology; Temperature; Time; Tissues; Translational Research; Variant; Work; base; design; high resolution imaging; image reconstruction; imaging approach; imaging modality; imaging platform; imaging study; imaging system; improved; in vivo; innovation; insight; instrumentation; magnetic field; molecular dynamics; molecular imaging; multidimensional data; multiphoton imaging; nervous system disorder; novel; novel strategies; optical imaging; parametric imaging; radio frequency; reconstruction; research and development; senescence; sensor; simulation; spatiotemporal; spectroscopic imaging; technology research and development; tool; treatment response

OVERALL ABSTRACT The Center for Magnetic Resonance Research (CMRR) has pioneered many of the MR methods that are critical in contemporary biomedical research including (but not limited to) the introduction of UHF instrumentation and accompanying techniques that overcome its challenges, accelerated MR imaging approaches, and many of the methods used to obtain biochemical information in vivo using spectroscopy and multinuclear capabilities. To continue the tradition of innovation, the long term goal of this Center proposal is to establish a national resource for enabling ultrahigh field (UHF, mostly 7T and above), magnetic resonance imaging (MRI) technologies to advance biomedical research and discovery. Towards building this P41 center, several technical research and development (TRD) projects are proposed that will work synergistically to realize the potential of our unique imaging resources. TRD1 involves the development of a multimodal imaging platform allowing simultaneous optical imaging, an invasive technology capable of visualizing neuronal activity at the single neuron and synapse level, with non-invasive MRI methods which provide high resolution functional MRI and connectivity data over the entire brain but at a coarser spatiotemporal resolution. This platform will provide unprecedented opportunities for detailed studies of brain function underlying behavior and inform future human studies using MRI alone. TRD2 focuses on establishing a sensitive molecular imaging platform combining novel systems solutions and advanced strategies to perform multinuclear MRI spectroscopy and imaging studies. This system will provide unparalleled sensitivity to probe molecular parameters to characterize tissue through molecular dynamics, spatial distributions of functional metabolic parameters and advanced multinuclear studies. TRD3 develops reconstruction strategies supporting highly accelerated high-resolution imaging approaches while incorporating methods to reduce the impact of physiologic motion and noise. These reconstruction methods advance the field by overcoming what otherwise would be limiting factors with respect to achievable temporal and spatial resolutions. TRD4 provides critical engineering solutions addressing both 1) radiofrequency (RF) coil (i.e. antennae) designs and safety for sensitive high resolution imaging at UHF without which the systems conceived of in TRD1 and TRD2 could not be realized and 2) methods to image around implants by minimizing heating and artifacts which if not addressed would limit the access of the UHF imaging to a large section of the population. As described, these projects can tackle the fundamental challenges of UHF. Only when these challenges are addressed can we develop the new approaches to truly advance basic and clinical translational research. In fact it is exactly this cycle of development and discovery that inspired, then justified, the spending of time and resources to develop, build and site the 10.5T system at our center. While the 10.5T scanner is at the center of the proposed developments, the impact of this Center on biomedical research will extend 7T and below as well as to fields beyond MRI (cognitive science, neuroscience, senescence, musculoskeletal disorders, neurological disorder, cancer among others).

总体摘要 磁共振研究中心 (CMRR) 开创了许多至关重要的 MR 方法 当代生物医学研究，包括（但不限于）UHF 仪器的引入和 克服挑战的伴随技术、加速 MR 成像方法以及许多 使用光谱学和多核能力获取体内生化信息的方法。到 延续创新传统，该中心提案的长期目标是建立国家资源 为了实现超高场（UHF，主要是 7T 及以上），磁共振成像 (MRI) 技术 推进生物医学研究和发现。为了建设这个 P41 中心，多项技术研究和 拟议的开发（TRD）项目将协同工作，以实现我们独特的潜力 影像资源。 TRD1 涉及多模态成像平台的开发，允许同时 光学成像，一种侵入性技术，能够可视化单个神经元和突触的神经元活动 级别，采用非侵入性 MRI 方法，可提供高分辨率功能 MRI 和连接数据 整个大脑，但具有较粗糙的时空分辨率。这个平台将提供前所未有的机遇 对行为背后的大脑功能进行详细研究，并为未来仅使用 MRI 的人类研究提供信息。 TRD2 专注于建立结合新颖的系统解决方案和先进的敏感分子成像平台 进行多核 MRI 光谱和成像研究的策略。该系统将提供无与伦比的 对探测分子参数的敏感性，通过分子动力学、空间分布来表征组织 功能代谢参数和高级多核研究。 TRD3 制定重建策略 支持高度加速的高分辨率成像方法，同时结合方法来减少 生理运动和噪音的影响。这些重建方法通过克服以下问题推动了该领域的发展： 否则将成为可实现的时间和空间分辨率的限制因素。 TRD4提供 关键工程解决方案解决 1) 射频 (RF) 线圈（即天线）设计和安全问题 在 UHF 下进行灵敏的高分辨率成像，否则 TRD1 和 TRD2 中设想的系统就无法实现 2) 通过最大限度地减少热量和伪影来对植入物周围进行成像的方法，如果不解决这些问题 将限制大部分人群获得 UHF 成像。如上所述，这些项目可以 解决 UHF 的根本挑战。只有解决了这些挑战，我们才能开发出新的产品。 真正推进基础和临床转化研究的方法。其实就是这个发展周期 和发现启发并证明了花费时间和资源来开发、建造和选址 我们中心的10.5T系统。虽然 10.5T 扫描仪是拟议开发的核心，但其影响 该生物医学研究中心的研究范围将扩展到 7T 及以下以及 MRI 以外的领域（认知科学、 神经科学、衰老、肌肉骨骼疾病、神经系统疾病、癌症等）。