Development of an Optimal MRI Platform for Prostate Investigations at 7 Tesla

开发用于 7 特斯拉前列腺研究的最佳 MRI 平台

• 批准号: 8234736
• 负责人: Gregory John Metzger
• 金额: $ 54.43万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8234736
• 关键词: Accounting; Aftercare; American; Anatomy; Area; Biomedical Research; Biopsy; Body Image; Brain; Cancer Detection; Clinical; Clinical Research; Data; Detection; Development; Diagnosis; Diagnostic; Diagnostic tests; Disease; Disease Progression; Early treatment; Effectiveness; Evaluation; Explosion; Functional Magnetic Resonance Imaging; Future; Goals; Gold; Human; Image; Individual; Indolent; Intervention; Investigation; Knowledge; Laboratories; Lead; Local Therapy; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of prostate; Manufacturer Name; Measurement; Measures; Methods; Monitor; Morbidity - disease rate; Noise; Pathology; Patient Monitoring; Patients; Performance; Physiological; Play; Prevalence; Problem Solving; Process; Prostate; RF coil; Radial; Recurrence; Reproducibility; Residual Tumors; Resolution; Role; Safety; Sampling Errors; Signal Transduction; Specificity; Spectrum Analysis; Staging; Surface; Techniques; Technology; Testing; Therapeutic; Time; Tissues; Variant; Work; alternative treatment; body system; cancer imaging; data acquisition; design; flexibility; human AMID protein; imaging modality; improved; instrument; interest; magnetic field; men; novel; pharmacokinetic model; reconstruction; research study; response; serum PSA; spectroscopic imaging; success; surveillance study; tool; treatment response; treatment strategy; tumor

DESCRIPTION (provided by applicant): The central hypothesis of this proposal is that technological developments that enable increased spatial, spectral and temporal resolution using the ultrahigh magnetic field of 7 Tesla (7T) will allow the development of quantitative and sensitive MRI markers that better identify prostate cancer and differentiate pathologically indolent from aggressive disease. Advantages of ultrahigh magnetic field MRI, due to gains of signal-to-noise- ratio (SNR), parallel imaging performance and novel and/or improved contrast mechanism have been amply demonstrated in the human brain. However, the organ systems and diseases associated with the human torso have been excluded from these advances to date due to difficulties that arise when the RF wavelength becomes significantly smaller than the object size, as it does in the human torso at 7T. Recent developments, largely coming from our laboratory, demonstrate that these challenges can be overcome. Therefore, we propose to undertake developments aimed at exploiting the potential gains available at higher magnetic fields for MRI to investigate a clinical problem in the human torso. The clinical problem we focus on is prostate cancer, which is the most common non-cutaneous malignancy of American men, one in six of whom will be diagnosed with the disease in their lifetime. Despite its prevalence, few diagnostic tools, mainly biopsy and serum PSA, exist for monitoring disease progression and determining treatment success. Biopsies, while able to locally monitor the prostate, are both invasive and subject to inherent sampling error leading to underestimation of tumor grade and extent of disease, while PSA lacks specificity for malignancy. Improved methods to monitor the disease state would greatly benefit prostate cancer management by distinguishing between patients with aggressive disease who would benefit from treatment versus patients with small, prostate-confined, nonaggressive tumors that may not require treatment, and thus avoiding treatment- associated morbidities in men with nonaggressive tumors. Further, improved methods are needed to identify early disease recurrence after treatment. Our long term goals are to identify quantitative and non-invasive anatomic and functional MRI markers useful for the identification of prostate cancer and for distinguishing biologically aggressive versus indolent disease, and to use these markers to evaluate treatment responses to individualized therapies. To achieve these long term goals, the main objectives of this application are to a) develop a 7 Tesla (7T) prostate platform including the development and evaluation of several interdependent components (RF coils, DCE-MRI methods, spectroscopic imaging methods and new spectral quantification techniques), b) evaluate the reproducibility of measuring quantitative prostate cancer markers to determine their potential sensitivity to change, c) evaluate the ability of the imaging methods and quantitative markers to detect cancer using pathology as a gold standard and d) determine the true advantage of 7T as a powerful tool to detect and monitor prostate cancer by performing a field comparison with 3T. PUBLIC HEALTH RELEVANCE: Upon successful completion of this proposal, an ultra high field magnetic resonance imaging (UHF MRI) platform will be developed taking advantage of the improved spatial, spectral and temporal resolution to quantitatively and sensitively measure several MRI markers to detect prostate cancer, determine the extent of disease, and assess pathological aggressiveness. The information provided by UHF MRI will improve our ability to characterize small volumes of disease and its progression, beyond what is currently possible at lower field strengths and with standard diagnostic tests. This technology is expected to be highly useful to monitor disease progression in patients under active surveillance, to determine the effectiveness of a therapy early in the therapeutic course to indicate if alternative treatment strategies are warranted, and to accurately target local therapies to reduce treatment morbidity and improve survival.

描述（由申请人提供）：本提案的中心假设是，利用7特斯拉（7T）的超高磁场提高空间、光谱和时间分辨率的技术发展，将允许开发定量和敏感的MRI标记物，更好地识别前列腺癌，并区分病理惰性和侵袭性疾病。超高磁场MRI的优势，由于信噪比（SNR）的增益，并行成像性能和新的和/或改进的对比机制，已经在人脑中得到了充分的证明。然而，与人体躯干相关的器官系统和疾病迄今为止一直被排除在这些进展之外，因为当射频波长明显小于物体尺寸时，就像在人体躯干7T时一样，会出现困难。最近的发展，主要来自我们的实验室，表明这些挑战是可以克服的。因此，我们建议开展旨在利用高磁场磁共振成像的潜在收益来研究人体躯干的临床问题的发展。我们关注的临床问题是前列腺癌，这是美国男性中最常见的非皮肤恶性肿瘤，六分之一的人将在他们的一生中被诊断出患有这种疾病。尽管它很流行，但很少有诊断工具，主要是活检和血清PSA，用于监测疾病进展和确定治疗成功。活检虽然能够局部监测前列腺，但具有侵入性，并且存在固有的采样误差，导致对肿瘤分级和疾病程度的低估，而PSA缺乏对恶性肿瘤的特异性。通过区分可从治疗中获益的侵袭性疾病患者与可能不需要治疗的小的、前列腺受限的、非侵袭性肿瘤患者，监测疾病状态的改进方法将极大地有利于前列腺癌的管理，从而避免非侵袭性肿瘤患者的治疗相关发病率。此外，需要改进的方法来识别治疗后疾病的早期复发。我们的长期目标是确定定量和非侵入性解剖和功能MRI标记物，用于识别前列腺癌和区分生物侵袭性与惰性疾病，并使用这些标记物评估个体化治疗的治疗反应。为了实现这些长期目标，本申请的主要目标是a)开发一个7特斯拉（7T）的前列腺平台，包括开发和评估几个相互依赖的组件（RF线圈，DCE-MRI方法，光谱成像方法和新的光谱量化技术），b)评估定量测量前列腺癌标志物的可重复性，以确定其对变化的潜在敏感性。c)评估成像方法和定量标记物以病理学为金标准检测癌症的能力，d)通过与3T进行现场比较，确定7T作为检测和监测前列腺癌的强大工具的真正优势。