Omics Core

组学核心

• 批准号: 10377893
• 负责人: Xiang Zhang
• 金额: $ 31.44万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-10 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10377893
• 关键词: Address; Applications Grants; Attention; Award; Bioinformatics; Biological; Biological Assay; Centers of Research Excellence; Chemicals; Clinical Research; Communities; Complex Mixtures; Continuing Education; Data; Data Analyses; Data Collection; Data Reporting; Development; Disease; Drug Interactions; Ensure; Environment; Equipment; Fee-for-Service Plans; Felis catus; Funding; Future; Goals; Health Sciences; Human Resources; Individual; Infrastructure; Institution; Intervention Studies; Leadership; Liver; Liver Dysfunction; Liver diseases; Malignant neoplasm of liver; Mass Spectrum Analysis; Methods; Modality; Modeling; Modification; Molecular Evolution; Peptides; Performance; Phase; Preparation; Procedures; Protein Analysis; Protein Fragment; Proteins; Proteomics; Protocols documentation; RNA; Reagent; Research; Research Activity; Research Personnel; Research Support; Resources; S10 grant; Sampling; Science; Services; Standardization; Statistical Data Interpretation; Techniques; Technology; Toxicology; Training; Training and Education; Translational Research; United States National Institutes of Health; Universities; base; career; career development; clinical infrastructure; data sharing; design; epitranscriptomics; experimental study; fatty liver disease; innovation; instrument; liver development; liver injury; meetings; member; metabolomics; method development; molecular marker; non-alcoholic; novel; nutrition; operation; problem drinker; programs; sample collection; small molecule; success; theories; tool; toxicant

Abstract: The primary function of OMICS Core (Core B) is to provide members of the University of Louisville Hepatobiology and Toxicology COBRE with the expertise, resources, and facilities needed for metabolomic, proteomic, and bioinformatic analyses of biological samples collected to study liver injury, nutrition, gut:liver interactions, and liver:environment/toxicant/drug interactions. Core B personnel will assist with the design of sample collection protocols, will drive the development and the execution of novel and robust chromatographic methods for sample separation and mass spectrometric methods for the analysis of proteins, peptides, and metabolites with a goal of providing a greater understanding of the evolution of molecular mechanisms that correlate with or participate in liver dysfunction. Core B will ensure uniformity and standardization in sample preparation, method development, instrument performance, data collection, data reporting, and data sharing. Core B endeavors to contribute to the overall success and utility of the COBRE and to enhance the infrastructure and the technical and academic capabilities of the institution as a whole. In addition to its function as a service core, Core B will also promote the education and training of the COBRE members and other biomedical investigators with regards to the state-of-the-art omics technologies; with particular attention to the COBRE junior investigators. Furthermore, Core B will become an independent and self-supporting entity using a set comprehensive approaches that have been already implemented and demonstrated their success in our Phase I COBRE. During the Hepatobiology and Toxicology COBRE Phase II period the goals of Core B will be addressed by the following Specific Aims: 1) To support current COBRE and UofL Health Science Center (HSC) projects. 2) To educate and train mentees and other investigators. 3) To develop new protocols and techniques. 4) To become self-sustaining feature of the COBRE and UofL HSC.

摘要：OMICS Core （Core B）的主要功能是为美国路易斯维尔大学（University of Louisville）的成员提供信息