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Omics Core

Omics Core
组学核心
批准号:
8978011
负责人:
Xiang Zhang
金额:
$46.09万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-05-15 至 2021-04-30
关键词:
AcidsAcroleinAffinityAlcohol NutritionAlcoholic Liver DiseasesAlcoholsAnimalsAttentionAttenuatedAutomobile DrivingBioinformaticsBiologicalBiotinBloodBlood specimenBody WeightCell LineCellsChronicComplex MixturesCurcuminDataData CollectionData ReportingData SetDevelopmentDrug InteractionsEmbryoEndotoxemiaEnsureEnvironmentEpigenetic ProcessExtracellular MatrixFecesFibroblastsGas ChromatographyGingerGoalsGrapefruitHepaticHigh Pressure Liquid ChromatographyHistone AcetylationHistonesHuman ResourcesInflammationInjuryInstitutionInterleukin-2IntestinesLactobacillus casei rhamnosusLiquid substanceLiverLiver DysfunctionLiver diseasesLungLysineMass Spectrum AnalysisMeasuresMediatingMetabolicMethodologyMethodsMolecularMolecular EvolutionMusNeural Crest CellOrganPatternPeptidesPerformancePost-Translational Protein ProcessingPreparationProtein AnalysisProtein FragmentProteinsProteomicsProtocols documentationResearchResearch InfrastructureResearch PersonnelResolutionResourcesRoleSamplingScienceSerumServicesStandardizationSulforaphaneTNFRSF5 geneTechniquesTechnologyTimeTissue SampleTissuesTraining and EducationTranscriptional RegulationUnsaturated FatsUrineabstractingadductalcohol effectdata sharingdesignexosomehistone methylationhistone modificationinstrumentliquid chromatography mass spectrometryliver injurylong chain fatty acidmalemeetingsmembermetabolomicsmethod developmentmultiple reaction monitoringnanoparticlenovelnutritionphosphoproteomicsprogramsprotein metaboliteresponsesample collectionsaturated fatsuccesstoxicanttributyrintwo-dimensional

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中文摘要
翻译
摘要: Omics Core的主要功能是为ULARC成员提供专业知识、资源和 对收集的生物样品进行代谢组学、蛋白质组学和生物信息学分析所需的设施, 研究肝损伤,营养,肠道:肝脏相互作用,肝脏:环境/毒物/药物相互作用。OMICS核心 工作人员将协助设计样本收集方案,将推动开发和 执行用于样品分离和质谱分析的新型和稳健的色谱方法 分析蛋白质、肽和代谢物的方法,目标是提供更大的 了解与肝功能障碍相关或参与肝功能障碍的分子机制的演变。 核心将确保样品制备、方法开发、仪器 绩效、数据收集、数据报告和数据共享。核心致力于为全球 ULARC的成功和实用性,并加强基础设施以及技术和学术能力 整个机构。除了作为服务中心的功能外,我们还将促进教育和 对ULARC成员进行关于最先进的组学和生物信息学方法的培训; 特别注意ULARC的初级调查员。
英文摘要
Abstract: The primary function of Omics Core is to provide members of the ULARC with the expertise, resources and facilities needed for metabolomic, proteomic and bioinformatic analyses of biological samples collected to study liver injury, nutrition, gut:liver interactions, and liver:environment/toxicant/drug interactions. OMICS Core personnel will assist with the design of sample collection protocols, will drive the development and the execution of novel and robust chromatographic methods for sample separation and mass spectrometric methods for the analysis of proteins, peptides, and metabolites with a goal of providing a greater understanding of the evolution of molecular mechanisms that correlate with or participate in liver dysfunction. The core will ensure uniformity and standardization in sample preparation, method development, instrument performance, data collection, data reporting and data sharing. The Core endeavors to contribute to the overall success and utility of the ULARC and to enhance the infrastructure and the technical and academic capabilities of the institution as a whole. In addition to its function as a service core, we will also promote the education and training of the ULARC members with regards to state-of–the-art Omics and Bioinformatics methods; with particular attention to the ULARC junior investigators.
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会议论文
Mechanistic and therapeutic investigation of secondary metastatic seeding from breast cancer bone lesion
  • 批准号:
    10650756
  • 项目类别:
  • 资助金额:
    $47.62万
  • 财政年份:
    2020
  • 负责人:
    Xiang Zhang
  • 依托单位:
Mechanistic and therapeutic investigation of secondary metastatic seeding from breast cancer bone lesion
  • 批准号:
    10028080
  • 项目类别:
  • 资助金额:
    $50.09万
  • 财政年份:
    2020
  • 负责人:
    Xiang Zhang
  • 依托单位:
Mechanistic and therapeutic investigation of secondary metastatic seeding from breast cancer bone lesion
  • 批准号:
    10204993
  • 项目类别:
  • 资助金额:
    $48.59万
  • 财政年份:
    2020
  • 负责人:
    Xiang Zhang
  • 依托单位:
Unveiling the mechanisms underlying secondary metastasis and possible therapeutic windows
  • 批准号:
    10818995
  • 项目类别:
  • 资助金额:
    $7.54万
  • 财政年份:
    2020
  • 负责人:
    Xiang Zhang
  • 依托单位:
国内基金
海外基金
Acrolein调控耳蜗核神经元-胶质细胞网络参与感音神经性耳聋发病机制的研究
acrolein在脊髓损伤后慢性疼痛发生发展中的作用及机制研究