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Neural coding of interneuron populations in the retina

视网膜中间神经元群的神经编码

基本信息

批准号：
10380747
负责人：
STEPHEN A BACCUS
金额：
$ 37.6万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-12-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10380747
关键词：
Address Age related macular degeneration Amacrine Cells Anatomy Cells Code Complex Computer Models Disease Distant Eye Movements Goals Image Inner Plexiform Layer Interneurons Location Measurement Measures Modeling Molecular Motion Mus Neural Network Simulation Neural Retina Neurons Neurophysiology - biologic function Optic Nerve Optics Pharmacogenetics Photoreceptors Population Population Heterogeneity Principal Investigator Process Research Resolution Retina Retinal Diseases Retinal Ganglion Cells Retinitis Pigmentosa Saccades Signal Transduction Stimulus System Testing Translating Vision Visual Visual Fields Visual Perception calcium indicator cell type comparative convolutional neural network ganglion cell individual response inhibitory neuron object motion optical imaging photoreceptor degeneration presynaptic programs relating to nervous system response retinal damage retinal prosthesis sample fixation sight restoration therapy design visual information visual stimulus

项目摘要

Abstract The vertebrate retina translates visual images into electrical signals in the optic nerve, initiating the basis of all visual perception. This process is accomplished by dozens of diverse types of interneurons, each of which comprises a population of many thousands of cells. Each of these populations cover the visual field, acting together to process different aspects of visual images. Although many informative studies of retinal neural function have used single cell recordings, understanding the coordinated actions of many cells requires the recording and analysis of cell populations. This proposal focuses on amacrine cells, a diverse population of inhibitory interneurons. In particular we study wide-field amacrine cells, a prominent class of cells that make long distance connections across the retina, acting to combine visual signals from distant locations in the image. We have little information assigning computations to specific cells of this type. Using genetically identified populations of wide-field amacrine cells in the mouse retina, we will record neural activity from these populations optically, along with simultaneously recording electrically from populations of retinal ganglion cells. Neural responses to complex stimuli including natural scenes will be interpreted using advanced computational models. The primary goals of these studies are to 1) perform the first population scale measurements of sparse wide-field amacrine cells, in particular to measure how their selectivity for visual features varies dynamically during natural scenes, 2) Analyze the neural code of these cells under natural scenes using state-of-the-art computational models that can capture retinal responses to arbitrarily complex stimuli, 3) Test the hypothesis that sparse wide-field amacrine cells perform similar computations on different channels of information, acting to remove correlations from the ganglion cell population during natural scenes. These results will have immediate applicability to the emerging field of retinal prostheses, as is used to treat prevalent diseases such as age-related macular degeneration and retinitis pigmentosa by replacing the function of the damaged retina with a high resolution electronic circuit. Measurements of the retinal neural code and the computations that are performed will be directly useful for incorporation into retinal prosthesis systems.

摘要