Depressive Symptoms and Tobacco Use Trajectories and Transitions across Young Adulthood

抑郁症状和烟草使用轨迹以及整个青年期的转变

基本信息

批准号：
10380174
负责人：
ALEXANDRA LOUKAS
金额：
$ 37.4万
依托单位：
UNIVERSITY OF TEXAS AT AUSTIN
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10380174
关键词：
Acetylcholine Age Alcohol consumption Animals Area Basal Ganglia Behavior Behavior Control Behavioral Chronic Cigarette Corpus striatum structure Data Development Dopamine Dopamine D2 Receptor Electronic Nicotine Delivery Systems Ethanol Female Fiber Goals Heterogeneity High Prevalence Impairment Infection Interneurons Intervention JUUL Longitudinal Studies Measures Medial Mediating Mental Depression Neurons Nicotine Dependence Operant Conditioning Outcome Parafascicular Nucleus Pathway interactions Pattern Photometry Rabies Receptor Signaling Recording of previous events Regulation Research Reversal Learning Rodent Role Self Stimulation Site Slice Subgroup Synapses Testing Thalamic structure Tobacco Tobacco Dependence Tobacco use United States Water addiction alcohol exposure alcohol use disorder associated symptom cholinergic contextual factors depressive symptoms drinking drinking behavior flexibility in vivo innovation male neurotransmission new therapeutic target novel therapeutics optogenetics polytobacco use postsynaptic presynaptic response selective expression sensor sociodemographics tobacco products transmission process university student vaping young adult

项目摘要

PROJECT SUMMARY Young adults have the highest prevalence of past-year depression and current tobacco use in the United States. Co-occurrence of depression and tobacco use is particularly problematic during young adulthood as nicotine addiction is solidified in this developmental period, and elevated levels of depressive symptoms promote sustained tobacco use and undermine quitting. Yet, there is limited research on young adults and evidence for the strength and direction of associations between depressive symptoms and tobacco use is inconclusive. Inconclusive findings indicate there may be heterogeneity in the patterns of associations between depressive symptoms and tobacco use across subgroups of young adults. Yet, few studies examine this heterogeneity. Further, most studies focus on cigarettes, although other products, such as electronic nicotine delivery systems, are increasingly prevalent and the concurrent use of two or more products (i.e., poly tobacco use) is more prevalent than single product use among young adults. Use of newly introduced vape pods, such as JUUL, is increasingly concerning. But, the role of vape pod use in the depressive symptoms-tobacco use association is not known. There is a critical need for longitudinal studies that identify for whom and under what conditions depressive symptoms are associated with use of all types of tobacco, and with transitions in use, such as from current to no tobacco use and vice versa. The primary objectives of this R01 are to determine if: 1) the role of depressive symptoms in tobacco use trajectories and transitions vary for subgroups across young adulthood, ages 18-34 and 2) the strength and direction of associations vary. We will identify moderating factors that capture the heterogeneity, and define for whom and under what conditions depressive symptoms are longitudinally associated with tobacco use outcomes. We will examine sociodemographic, intrapersonal, and contextual moderating factors, and all types of tobacco products and outcomes, including initiation, sustained use, addiction, cessation, poly tobacco use, and transitions in use. To do so, we will use eight waves of existing data collected in 2014-2019 from 5,482 initially 18-29 year old college students. The Specific Aims are to: 1) Identify the role of depressive symptoms in longitudinal tobacco use trajectories and transitions, and elucidate the temporal associations between depressive symptoms and tobacco use; 2) Examine the moderating roles of sociodemographic, intrapersonal, and contextual factors in the longitudinal trajectories, transitions, and temporal associations; and 3) Determine the role of vape pods, like JUUL, in the longitudinal tobacco use trajectories, transitions, and temporal associations. The expected outcome is identification of subgroups most vulnerable to initiating and continuing tobacco use, given elevated depressive symptoms. Results can be used to tailor tobacco interventions and determine to whom they should be targeted.

项目摘要的年轻人在美国的抑郁症患病率最高，当前的烟草使用率最高。在成年期间，由于尼古丁成瘾在这一发育期间巩固了抑郁症和烟草使用的同时出现，抑郁症状的水平升高会促进持续的烟草使用和破坏戒烟。然而，对年轻人的研究和证据有限，证明抑郁症状和烟草使用之间关联的力量和方向尚无定论。不确定的发现表明，抑郁症状和烟草在跨年轻人的亚组之间使用之间的关联模式可能存在异质性。然而，很少有研究检查这种异质性。此外，尽管其他产品（例如电子尼古丁递送系统）越来越普遍，但大多数研究都集中在香烟上，并且同时使用两种或多种产品（即聚烟草使用）比年轻人中的单一产品更为普遍。使用新引入的vape豆荚（例如Juul）的使用越来越令人担忧。但是，尚不清楚使用vape豆荚在抑郁症状中的作用。对纵向研究的迫切需要，可以确定抑郁症状与使用所有类型的烟草以及使用的过渡有关的抑郁症状，例如从当前到烟草的使用，反之亦然，反之亦然。该R01的主要目标是确定：1）抑郁症状在烟草使用轨迹中的作用和过渡在整个成年期，年龄在18-34岁和2岁的年轻人中的子群体各不相同）。我们将确定捕获异质性的调节因素，并定义与烟草使用结果纵向相关的抑郁症状和在哪些条件下。我们将研究社会人口统计学，人际关系和上下文调节因素，以及所有类型的烟草产品和结果，包括启动，持续使用，成瘾，停止，托巴科使用以及使用中的过渡。为此，我们将使用八波在2014 - 2019年收集的现有数据，从最初18-29岁的大学生收集的5,482浪。具体目的是：1）确定抑郁症状在纵向烟草使用轨迹和过渡中的作用，并阐明抑郁症状与烟草使用之间的时间关联； 2）检查社会人口统计学，人际关系和情境因素在纵向轨迹，过渡和时间关联中的调节作用； 3）确定vape豆荚（如Juul）在纵向烟草使用轨迹，过渡和时间关联中的作用。预期的结果是确定最容易发起和持续烟草使用的亚组，鉴于抑郁症状升高。结果可用于量身定制烟草干预措施，并确定应向谁定位。