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The Etiology of Risk: Alcohol and Drug Use Disorders and Suicidal Behavior

风险的病因学：酒精和药物滥用障碍以及自杀行为

基本信息

批准号：
10380105
负责人：
ALEXIS C EDWARDS
金额：
$ 45.9万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-20 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10380105
关键词：
Accounting Address Alcohol abuse Alcohol consumption Biometry Cause of Death Censuses Cessation of life Characteristics Clinical Data Collaborations Communities Complex Data Data Set Development Drug Use Disorder Environment Environmental Risk Factor Epidemic Epidemiologic Methods Epidemiology Etiology Exposure to Family Family history of Gender Genetic Genetic Risk Goals Healthcare Individual Influentials Intervention Investigation Life Cycle Stages Link Longevity Major Depressive Disorder Measures Mediating Mediation Medical Mental disorders Methodology Modeling Mood Disorders Neighborhoods Outcome Pathway interactions Persons Pharmaceutical Preparations Population Heterogeneity Prevention Process Psychotic Disorders Recording of previous events Registries Research Research Design Resources Risk Risk Assessment Risk Behaviors Risk Factors Role Sample Size Sampling Sex Differences Statistical Methods Statistical Models Structure Substance Use Disorder Substance abuse problem Suicide Suicide attempt Suicide prevention Sweden Testing Visit age effect age group alcohol risk base causal model cohort completed suicide design ethnic diversity genetic epidemiology health care service utilization health care settings high risk improved innovation interest mortality novel peer power analysis proband psychiatric comorbidity secondary analysis sex social epidemiology sociodemographics socioeconomics substance misuse suicidal behavior suicidal risk suicide rate transmission process

项目摘要

Project Summary The current proposal seeks to clarify the mechanisms underlying observed associations between alcohol and drug use disorders (AUD and DUD, respectively; SUD collectively) and suicidal behaviors (SB), including suicide attempts and completions. The research team has an extensive history of productive collaborations, including, in particular, psychiatric and substance use disorder research. We have access to Swedish national registries including medical, criminal, census, family, and socioeconomic data for nearly 11 million individuals; these resources will be linked to create detailed datasets encompassing a wide range of risk factors at personal, familial, and environmental levels. We will utilize these resources to extend our prior research through our pursuit of four specific aims. The first aim is to clarify the extent to which AUD/DUD is related to risk of suicidal behavior, accounting for critical confounding factors such as psychiatric comorbidity. Using genetic epidemiologic methods in conjunction with other informative designs aimed at facilitating causal inference, we will address whether the observed association is attributable to confounders, causal processes, or both. Second, we will examine how familial AUD, DUD, and SB impact individual risk, disentangling genetic from environmental components of risk through novel study designs developed through our ongoing collaboration. Parallel analyses will examine the role of exposure to AUD, DUD, and SB in the non-familial environment. Third, we will dissect health care utilization among those with AUD/DUD to identify potential SB risk indicators, with two primary foci: i) timing of and reason for doctor visits, and ii) associations between psychiatric/SUD medication usage and outcomes. Finally, we will incorporate our findings from the first three specific aims into integrative etiologic models of risk, separately for suicide attempts and completions. These models will be structured in a developmentally informative manner and enable us to identify mediational processes among risk factors for both outcomes. Critically, Sweden and the US have highly comparable rates of suicidal behavior and share many characteristics, including an ethnically and socioeconomically diverse population; however, the US lacks registry resources comparable to those available in Sweden. We expect that the statistical power of these registries, in conjunction with the research team's extensive expertise in psychiatric and substance abuse research, social and genetic epidemiology, and causal modeling, will yield substantive findings on the relationship between AUD/DUD and SB, with important implications for improving our efforts at SB prevention and intervention.

项目总结

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Suicidal ideation during adolescence: The roles of aggregate genetic liability for suicide attempts and negative life events in the past year.

DOI：
10.1111/jcpp.13653
发表时间：
2022-10
期刊：
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
影响因子：
7.6
作者：
Lannoy, Severine;Mars, Becky;Heron, Jon;Edwards, Alexis C.
通讯作者：
Edwards, Alexis C.

Risks of Depression and Suicide After Diagnosis With Heart Failure: A National Cohort Study.

DOI：
10.1016/j.jchf.2022.07.007
发表时间：
2022-11
期刊：
JACC-HEART FAILURE
影响因子：
13
作者：
Crump, Casey;Sundquist, Jan;Kendler, Kenneth S.;Sieh, Weiva;Edwards, Alexis C.;Sundquist, Kristina
通讯作者：
Sundquist, Kristina

Comparative risk of suicide by specific substance use disorders: A national cohort study.

DOI：
10.1016/j.jpsychires.2021.10.017
发表时间：
2021-12
期刊：
Journal of psychiatric research
影响因子：
4.8
作者：
Crump C;Sundquist J;Kendler KS;Edwards AC;Sundquist K
通讯作者：
Sundquist K

Alcohol consumption and internalising disorders in young adults of ALSPAC: a population-based study.

DOI：
10.1136/jech-2020-213922
发表时间：
2020-12
期刊：
Journal of epidemiology and community health
影响因子：
6.3
作者：
Fernandes GS;Lewis G;Hammerton G;Abeysekera K;Mahedy L;Edwards A;Lewis G;Hickman M;Heron J
通讯作者：
Heron J

The Sources of Parent-Child Transmission of Risk for Suicide Attempt and Deaths by Suicide in Swedish National Samples.