The Etiology of Risk: Alcohol and Drug Use Disorders and Suicidal Behavior
The Etiology of Risk: Alcohol and Drug Use Disorders and Suicidal Behavior
批准号:
10380105
负责人:
ALEXIS C EDWARDS
金额:
$45.9万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
未结题
起止时间:
2019-05-20 至 2025-01-31
关键词:
AccountingAddressAlcohol abuseAlcohol consumptionBiometryCause of DeathCensusesCessation of lifeCharacteristicsClinical DataCollaborationsCommunitiesComplexDataData SetDevelopmentDrug Use DisorderEnvironmentEnvironmental Risk FactorEpidemicEpidemiologic MethodsEpidemiologyEtiologyExposure toFamilyFamily history ofGenderGeneticGenetic RiskGoalsHealthcareIndividualInfluentialsInterventionInvestigationLife Cycle StagesLinkLongevityMajor Depressive DisorderMeasuresMediatingMediationMedicalMental disordersMethodologyModelingMood DisordersNeighborhoodsOutcomePathway interactionsPersonsPharmaceutical PreparationsPopulation HeterogeneityPreventionProcessPsychotic DisordersRecording of previous eventsRegistriesResearchResearch DesignResourcesRiskRisk AssessmentRisk BehaviorsRisk FactorsRoleSample SizeSamplingSex DifferencesStatistical MethodsStatistical ModelsStructureSubstance Use DisorderSubstance abuse problemSuicideSuicide attemptSuicide preventionSwedenTestingVisitage effectage groupalcohol riskbasecausal modelcohortcompleted suicidedesignethnic diversitygenetic epidemiologyhealth care service utilizationhealth care settingshigh riskimprovedinnovationinterestmortalitynovelpeerpower analysisprobandpsychiatric comorbiditysecondary analysissexsocial epidemiologysociodemographicssocioeconomicssubstance misusesuicidal behaviorsuicidal risksuicide ratetransmission process
中文摘要
项目总结
英文摘要
Project Summary
The current proposal seeks to clarify the mechanisms underlying observed associations between alcohol and
drug use disorders (AUD and DUD, respectively; SUD collectively) and suicidal behaviors (SB), including suicide
attempts and completions. The research team has an extensive history of productive collaborations, including,
in particular, psychiatric and substance use disorder research. We have access to Swedish national registries
including medical, criminal, census, family, and socioeconomic data for nearly 11 million individuals; these
resources will be linked to create detailed datasets encompassing a wide range of risk factors at personal,
familial, and environmental levels. We will utilize these resources to extend our prior research through our pursuit
of four specific aims. The first aim is to clarify the extent to which AUD/DUD is related to risk of suicidal behavior,
accounting for critical confounding factors such as psychiatric comorbidity. Using genetic epidemiologic methods
in conjunction with other informative designs aimed at facilitating causal inference, we will address whether the
observed association is attributable to confounders, causal processes, or both. Second, we will examine how
familial AUD, DUD, and SB impact individual risk, disentangling genetic from environmental components of risk
through novel study designs developed through our ongoing collaboration. Parallel analyses will examine the
role of exposure to AUD, DUD, and SB in the non-familial environment. Third, we will dissect health care
utilization among those with AUD/DUD to identify potential SB risk indicators, with two primary foci: i) timing of
and reason for doctor visits, and ii) associations between psychiatric/SUD medication usage and outcomes.
Finally, we will incorporate our findings from the first three specific aims into integrative etiologic models of risk,
separately for suicide attempts and completions. These models will be structured in a developmentally
informative manner and enable us to identify mediational processes among risk factors for both outcomes.
Critically, Sweden and the US have highly comparable rates of suicidal behavior and share many characteristics,
including an ethnically and socioeconomically diverse population; however, the US lacks registry resources
comparable to those available in Sweden. We expect that the statistical power of these registries, in conjunction
with the research team's extensive expertise in psychiatric and substance abuse research, social and genetic
epidemiology, and causal modeling, will yield substantive findings on the relationship between AUD/DUD and
SB, with important implications for improving our efforts at SB prevention and intervention.
期刊论文(11)
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DOI:
10.1111/jcpp.13653
发表时间:
2022-10
期刊:
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
影响因子:
7.6
作者:
[Lannoy, Severine, Mars, Becky, Heron, Jon, Edwards, Alexis C.]
通讯作者:
Edwards, Alexis C.
DOI:
10.1016/j.jchf.2022.07.007
发表时间:
2022-11
期刊:
JACC-HEART FAILURE
影响因子:
13
作者:
[Crump, Casey, Sundquist, Jan, Kendler, Kenneth S., Sieh, Weiva, Edwards, Alexis C., Sundquist, Kristina]
通讯作者:
Sundquist, Kristina
DOI:
10.1016/j.jpsychires.2021.10.017
发表时间:
2021-12
期刊:
Journal of psychiatric research
影响因子:
4.8
作者:
[Crump C, Sundquist J, Kendler KS, Edwards AC, Sundquist K]
通讯作者:
Sundquist K
DOI:
10.1093/jncics/pkad046
发表时间:
2023-07-03
期刊:
JNCI cancer spectrum
影响因子:
4.4
作者:
[]
通讯作者:
Alcohol consumption and internalising disorders in young adults of ALSPAC: a population-based study.
DOI:
10.1136/jech-2020-213922
发表时间:
2020-12
期刊:
Journal of epidemiology and community health
影响因子:
6.3
作者:
[Fernandes GS, Lewis G, Hammerton G, Abeysekera K, Mahedy L, Edwards A, Lewis G, Hickman M, Heron J]
通讯作者:
Heron J
共 6 条
Harnessing advances in the genetics of suicidality to identify and dissect psychosocial pathways to risk
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批准号:10580817
-
项目类别:
-
资助金额:$55.08万
-
财政年份:2022
-
负责人:ALEXIS C EDWARDS
-
依托单位:
Harnessing advances in the genetics of suicidality to identify and dissect psychosocial pathways to risk
-
批准号:10419131
-
项目类别:
-
资助金额:$58.09万
-
财政年份:2022
-
负责人:ALEXIS C EDWARDS
-
依托单位:
Genetic influences on developmental heterogeneity of alcohol use disorder
-
批准号:8352210
-
项目类别:
-
资助金额:$14.39万
-
财政年份:2012
-
负责人:ALEXIS C EDWARDS
-
依托单位:
Genetic influences on developmental heterogeneity of alcohol use disorder
-
批准号:8902748
-
项目类别:
-
资助金额:$14.45万
-
财政年份:2012
-
负责人:ALEXIS C EDWARDS
-
依托单位:
Genetic influences on developmental heterogeneity of alcohol use disorder
-
批准号:8706675
-
项目类别:
-
资助金额:$14.02万
-
财政年份:2012
-
负责人:ALEXIS C EDWARDS
-
依托单位:
Genetic influences on developmental heterogeneity of alcohol use disorder
-
批准号:8517523
-
项目类别:
-
资助金额:$13.44万
-
财政年份:2012
-
负责人:ALEXIS C EDWARDS
-
依托单位:
Genetic Influences on the Overlap Between Internalizing and Alcohol Problems
-
批准号:8153116
-
项目类别:
-
资助金额:$5.26万
-
财政年份:2010
-
负责人:ALEXIS C EDWARDS
-
依托单位:
Genetic Influences on the Overlap Between Internalizing and Alcohol Problems
-
批准号:7998762
-
项目类别:
-
资助金额:$5.38万
-
财政年份:2010
-
负责人:ALEXIS C EDWARDS
-
依托单位:
The Genetic Architecture of Aggressive Behavior
-
批准号:6935104
-
项目类别:
-
资助金额:$3.01万
-
财政年份:2005
-
负责人:ALEXIS C EDWARDS
-
依托单位:
The Genetic Architecture of Aggressive Behavior
-
批准号:7246470
-
项目类别:
-
资助金额:$3.01万
-
财政年份:2005
-
负责人:ALEXIS C EDWARDS
-
依托单位:
The Genetic Architecture of Aggressive Behavior
-
批准号:7065220
-
项目类别:
-
资助金额:$3.01万
-
财政年份:2005
-
负责人:ALEXIS C EDWARDS
-
依托单位:
海外基金