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Genetic Influences on the Overlap Between Internalizing and Alcohol Problems

遗传对内化和酒精问题重叠的影响

基本信息

批准号：
8153116
负责人：
ALEXIS C EDWARDS
金额：
$ 5.26万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-27 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8153116
关键词：
Address Affect Aggressive behavior Agoraphobia Alcohol abuse Alcohol consumption Alcohol dependence Alcohols Anxiety Disorders Architecture Area Behavioral Behavioral Genetics Biological Models C10 Categories Comorbidity Complex Data Development Diagnosis Diagnostic Disease Drosophila genus Drosophila melanogaster Environmental Risk Factor Epidemiologic Methods Epidemiologic Studies Epidemiology Equation Genes Genetic Genetic Research Genetic Risk Genetic Structures Genomics Goals Human Human Genetics Individual Literature Major Depressive Disorder Measures Mental Depression Methods Modeling Mood Disorders National Institute on Alcohol Abuse and Alcoholism Panic Disorder Pathway interactions Phenotype Population Prevention Process Research Research Support Research Training Social Phobia Staging Structure Symptoms Techniques Testing Training Translational Research Twin Multiple Birth Twin Studies Variant Work alcohol misuse alcohol use disorder genetic analysis genetic epidemiology genetic variant genome wide association study improved psychogenetics public health relevance skills tool training project trait

项目摘要

DESCRIPTION (provided by applicant): Project Summary: The broad research objective of the proposed project is to investigate the relationship between internalizing symptoms and alcohol problems. Specifically, this will entail an analysis of the genetic and environmental liability shared across traits and an effort to identify genetic variants influencing this association. One component of the project will address these goals through the use of genetic epidemiology. By studying the relationship between these traits in a population of twins, it is possible to partition variance into that which is attributable to genetic versus environmental factors. Using measures of internalizing symptoms (across multiple disorders) and alcohol problems, the research described in this proposal will address questions about the degree to which shared latent genetic liability influences the association between these traits, and whether that shared liability is specific to particular manifestations of internalizing (such as symptoms of major depression, or symptoms of social phobia) or is common across internalizing phenotypes. The second component of the project builds on results from the twin component. Using information about the structure of genetic influences common to internalizing symptoms and alcohol misuse, a single quantitative phenotype will be constructed that approximates an individual's genetic liability to overlap between internalizing and alcohol problems. This phenotype will be used as the dependent variable in a genome-wide association study, with the goal of identifying genetic variants associated with the composite phenotype. PUBLIC HEALTH RELEVANCE: Project Narrative: Research initiatives of the NIAAA include delineation of genetic and behavioral vulnerability to alcohol use and disorders. The proposed project will improve understanding of the latent and specific genetic influences on an internalizing pathway to alcohol use. This information can be used to guide treatment and prevention of both internalizing disorders and alcohol use disorders.

描述（由申请人提供）：项目概要：该项目的广泛研究目标是调查内化症状和酒精问题之间的关系。具体而言，这将需要分析跨性状共享的遗传和环境责任，并努力识别影响这种关联的遗传变异。该项目的一个组成部分将通过使用遗传流行病学来实现这些目标。通过研究双胞胎群体中这些特征之间的关系，可以将方差分为遗传因素和环境因素。使用内化症状（跨多种疾病）和酒精问题的措施，本提案中描述的研究将解决有关共享潜在遗传责任影响这些特征之间关联的程度的问题，以及共享责任是否特定于内化的特定表现（如重度抑郁症的症状或社交恐惧症的症状）或在内化表型中常见。该项目的第二个组成部分建立在双组成部分的成果基础上。利用内化症状和酒精滥用常见的遗传影响结构的信息，将构建一个单一的定量表型，近似一个人的遗传倾向内化和酒精问题之间的重叠。该表型将用作全基因组关联研究中的因变量，目的是鉴定与复合表型相关的遗传变异。公共卫生相关性：项目叙述：NIAAA的研究计划包括对酒精使用和疾病的遗传和行为脆弱性的描述。拟议的项目将提高对酒精使用内在途径的潜在和特定遗传影响的理解。这些信息可用于指导治疗和预防内化障碍和酒精使用障碍。