Administrative Core

行政核心

• 批准号: 10385185
• 负责人: Hemali Phatnani
• 金额: $ 44.71万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10385185
• 关键词: Administrative; Core

ADMINISTRATIVE CORE (ADM): PROJECT SUMMARY The Administrative Core (ADM) is a necessary component of the Columbia University Senescence Tissue Mapping (CUSTMAP) Center; it will provide research and logistical oversight and facilitate communication amongst all Center Cores as well as with the SenNet Consortium Organization and Data Coordination Center (CODCC), the SenNet consortium at large, and the NIH. The ADM, composed of a Director, all Center PIs (MPIs), an Executive Committee (all Core leadership), and support staff (Program Manager and Systems Analyst), will oversee and coordinate the direction of three Cores (a Biospecimen Core (BIO), a Biological Analysis Core (BAC), and a Data Analysis Core (DAC)). These Cores will contribute to the study of senescence in three primary tissue types, i.e., skin, brain, and spinal cord, across the adult lifespan. The ADM will have three main functions in support of the CUSTMAP Center and ultimately the SenNet consortium initiative. The first is Leadership, highlighted in Aim 1: Provide scientific leadership and governance structure to ensure integration and function of the CUSTMAP Center components and activities. CUSTMAP Center activities will span multiple sites (CUIMC-All Cores, Edinburgh University-BIO, New York Genome Center-BAC, and New York University- DAC) and therefore will require a central governing and organizing structure. The ADM will be the hub for decision making, all Center documentation, and adherence to ethical policies. Importantly, the ADM will ensure the CUSTMAP Center research is compliant with agreed upon standards and a resource sharing plan, formally set by the Center and with the NIH. The second role is Center Coordination, highlighted in Aim 2: Facilitate internal communication and promote synergy within the CUSTMAP Center. The ADM will provide coordination across all CUSTMAP Center Cores. Central to this Aim is an innovative, customized laboratory information management system (LIMS) in coordination with OpenSpecimen to track samples, the associated metadata, and experimental outputs. The ADM will organize regular Executive Committee meetings as an open forum for the sharing of successes, ideas and trouble shooting. The ADM will compile biannual Progress reports from each Core for evaluation by the SenNet Steering Committee and annual reports for evaluation by an Internal Advisory Board (internal to CUIMC, external to CUSTMAP). Finally, the ADM will facilitate Network Coordination, highlighted in Aim 3: Foster collaboration and integration of the CUSTMAP Center with the SenNet consortium. The ADM will collaborate with the CUSTMAP DAC and the SenNet CODCC to develop harmonious Standard Operating Practices (SOPs), Common Data Elements (CDEs) and suitable data packages and will oversee the delivery of quality data to the CODCC. The ADM will also leverage interactions with other TMCs in the SenNet consortium to optimize SOPs, assay protocols, consent materials, and data analysis, etc. The ADM will provide the seamless integration of multiple moving parts, at multiple sites, to produce high quality, meaningful data towards the SenNet goal of high-resolution atlases of senescence in diverse healthy tissues.

行政核心（ADM）：项目摘要 行政核心（ADM）是哥伦比亚大学衰老组织的必要组成部分 映射（Custmap）中心；它将提供研究和后勤的监督，并促进沟通 在所有中心核心以及Sennet联盟组织和数据协调中心中 （CODCC），整个Sennet财团和NIH。由董事组成的ADM，所有中心PI（MPI）， 执行委员会（所有核心领导）和支持人员（计划经理和系统分析师）将 监督和协调三个核心的方向（生物测量核（BIO），生物分析核心 （BAC）和数据分析核心（DAC））。这些核心将有助于研究三个主要的衰老 整个成人寿命的组织类型，即皮肤，大脑和脊髓。 ADM将具有三个主要功能 支持Custmap中心和最终的Sennet财团倡议。首先是领导 AIM 1中突出显示：提供科学领导和治理结构以确保整合和 Custmap中心组件和活动的功能。 Custmap中心活动将跨越多个 站点（Cuimc-All Cores，Edinburgh University-Bio，New York Genome Center-Bac和New York University- DAC），因此需要中央管理和组织结构。 ADM将是枢纽 决策，所有中心文件以及遵守道德政策。重要的是，ADM将确保 Custmap中心研究符合同意的标准和资源共享计划，正式 由中心和NIH设置。第二个角色是中心协调，在AIM 2中突出显示：促进 内部通信并促进Custmap中心内的协同作用。 ADM将提供 所有Custmap中心核心的协调。这个目标的核心是创新的定制实验室 信息管理系统（LIMS）与OpenSpecemen协调以跟踪样本，相关的样本 元数据和实验输出。 ADM将组织常规执行委员会会议作为公开 共享成功，想法和麻烦拍摄的论坛。 ADM将编译双年度进度报告 从每个核心进行评估，由Sennet指导委员会和年度报告，以进行内部评估 顾问委员会（CUIMC内部，Custmap外部）。最后，ADM将促进网络 协调，在AIM 3中突出显示：促进Custmap中心的协作和集成与 Sennet财团。 ADM将与Custmap DAC和Sennet Codcc合作开发 和谐的标准操作实践（SOP），常见数据元素（CD）和合适的数据包 并将监督质量数据向CODCC的传递。 ADM还将利用与其他 Sennet联盟中的TMC优化SOP，测定方案，同意材料和数据分析等。 ADM将在多个站点提供多个运动部件的无缝集成，以产生高质量， 有意义的数据朝着各种健康组织中衰老的高分辨率地图集的sennet目标。