Wisconsin Alzheimer's Disease Research center

威斯康星州阿尔茨海默病研究中心

• 批准号: 10385829
• 负责人: Sanjay Asthana
• 金额: $ 301.49万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10385829
• 关键词: Adult; Aging; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease patient; Alzheimer’s disease biomarker; Autopsy; Biochemical; Biological; Biological Markers; Blood; Blood Vessels; Brain; Caregiver support; Caring; Cells; Cerebrospinal Fluid; Clinical; Clinical Data; Cohort Studies; Collaborations; Communities; Competence; Consultations; County; DNA; DNA Repository; Data; Data Analyses; Data Collection; Data Set; Data Storage and Retrieval; Dementia; Development; Diagnosis; Disease; Disease Progression; Doctor of Philosophy; Early Diagnosis; Early treatment; Enrollment; Ensure; Evaluation; Exercise; Faculty; Family; Funding; General Population; Genetic; Goals; Health Professional; Health Technology; Heterogeneity; Individual; Informatics; Infrastructure; International; Leadership; Link; Logistics; Mentors; Mission; Modeling; Molecular; Native Americans; Nature; Neurobiology; Neurosciences; Oneida; Palliative Care; Participant; Pathologic; Pathology; Patient Care; Patient Recruitments; Patients; Postdoctoral Fellow; Prevention strategy; Process; Recording of previous events; Regulation; Research; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Role; Safety; Sampling; Seminal; Specimen; Standardization; Stem Cell Research; Symptoms; Techniques; Telemedicine; Time; Training; Training Support; Underrepresented Minority; Underrepresented Populations; Wisconsin; Work; base; biomarker discovery; brain tissue; clinical diagnosis; clinical phenotype; clinical practice; collaborative environment; computerized tools; data management; dissemination research; education research; effective therapy; end of life; experience; genetic risk factor; genome wide association study; healthy aging; implementation research; improved; induced pluripotent stem cell; innovation; mHealth; middle age; multidisciplinary; neuroimaging; neuropathology; next generation; novel; outreach; outreach program; pre-clinical; programs; recruit; societal costs; treatment strategy; volunteer; web services

PROJECT SUMMARY - OVERALL The overall goal of the renewal of the Wisconsin Alzheimer's Disease Research Center (ADRC) is to support cutting-edge, innovative research on the pathobiology, early diagnosis and treatment of Alzheimer's disease (AD) and related illnesses. This goal will be accomplished by establishing a stimulating, interdisciplinary environment for collaborative research and providing invaluable clinical data, ante-mortem biospecimens, and autopsy brain tissue. Funded by NIA in 2009, the Wisconsin ADRC will support eight well-integrated Cores, including a new Care Research Core and Research Education Component (REC) that will support timely, innovative research, which will: 1) characterize preclinical biomarkers of AD and their role in predicting transition from preclinical to clinical stages of the disease; 2) investigate the neurobiology of AD; 3) identify novel vascular and genetic risk factors, linking them to the disease pathology and clinical phenotype; 4) incorporate contemporary biochemical and molecular techniques into clinical-pathologic cohort studies, including omics and next generation genetic sequencing; and 5) participate and facilitate the missions of other federal, state and local agency-supported aging and dementia research programs. The overall goals of the Center will be accomplished through coordinated activities of its eight Cores and the REC. The Administrative Core will provide scientific leadership to the ADRC as a whole. The Clinical Core will perform standardized evaluations and collect UDS and additional data on all research participants. It will work closely with the Outreach, Recruitment and Engagement (ORE) Core and the Inclusion of Underrepresented Groups (URG) Core to enhance enrollment of underrepresented minorities. The Data Management and Statistical (DMS) Core will continue to meet all data management, informatics, and statistical needs and support all the PC- and web-based services and processes. The Neuropathology Core will continue to provide neuropathologic diagnoses and process, store, and distribute antemortem biospecimens and postmortem brain tissue to support novel research in AD. The ORE Core will provide a broad-range of educational and outreach programs about AD and the Wisconsin ADRC missions to recruit research volunteers, especially those from URGs into the Clinical Core and other NIA-funded initiatives, such as ADCS, ADNI, NCRAD and GWAS studies. The URG Core will work closely with the ORE and Clinical Cores to enhance recruitment and retention of URG participants into the ADRC. The new Biomarker Core will support and provide access to resources in preclinical neuroimaging and cerebrospinal fluid (CSF) biomarkers of AD. The REC will coordinate closely with the Clinical, ORE, URG, Neuropathology and DMS Cores to provide state-of-the-art, competency-based training to postdoctoral fellows and early-stage faculty in all aspects of aging & dementia research. The new Care Research Core will provide novel expertise and resources to conduct innovative studies that will enhance patient care and change clinical practice.

项目总结--总体 威斯康星州阿尔茨海默病研究中心(ADRC)更新的总体目标是支持 阿尔茨海默病的病理生物学、早期诊断和治疗方面的前沿创新研究 (Ad)及相关疾病。这一目标将通过建立一个激动人心的、跨学科的 为协作研究和提供宝贵的临床数据、死前生物显微镜和 验尸脑组织。由NIA于2009年资助的威斯康星州ADRC将支持八个集成良好的核心， 包括一个新的关怀研究核心和研究教育组成部分(REC)，将及时支持、 创新性研究，将：1)表征AD的临床前生物标志物及其在预测转变中的作用 从疾病的临床前阶段到临床阶段；2)研究AD的神经生物学；3)识别新的血管 和遗传危险因素，将它们与疾病病理和临床表型联系起来；4)结合 现代生化和分子技术纳入临床-病理队列研究，包括组学和 下一代基因测序；以及5)参与和协助其他联邦、州和地方的任务 机构支持的老龄化和痴呆症研究计划。中心的总体目标将会实现 通过其八个核心和区域经济共同体的协调活动。行政核心将提供科学的 对整个ADRC的领导力。临床核心将执行标准化评估并收集UDS 以及关于所有研究参与者的额外数据。它将与外联、征聘和 接洽(ORE)核心和纳入代表不足群体(URG)核心以提高注册 代表人数不足的少数族裔。数据管理和统计(DMS)核心将继续满足所有 数据管理、信息学和统计需求，并支持所有基于PC和Web的服务和 流程。神经病理核心将继续提供神经病理诊断和流程， 储存和分发生前生物标本和死后脑组织，以支持AD的新研究。 ORE核心将提供广泛的关于AD和 威斯康星州ADRC任务招募研究志愿者，特别是那些来自URGs的志愿者进入临床核心和 NIA资助的其他举措，如ADCS、ADNI、NCRAD和全球气候变化研究。URG核心将密切合作 与ORE和临床核心一起，加强URG参与者在ADRC中的招募和留住。这个 新的Biomarker Core将支持并提供对临床前神经成像和脑脊髓资源的访问 AD的体液(CSF)生物标志物。REC将与临床、ORE、URG、神经病理学和 DMS核心为博士后研究员和早期教师提供最先进的基于能力的培训 在衰老和痴呆症研究的方方面面。新的护理研究核心将提供新的专业知识和 用于开展创新研究的资源，这些研究将加强患者护理并改变临床实践。