Administrative Core

项目摘要-行政核心（核心A） 威斯康星州阿尔茨海默病研究中心（ADRC）的总体使命是提供一个 基础设施和资源有利于进行尖端的课外资助的研究阿尔茨海默氏症 疾病（AD）和相关疾病，特别关注AD的临床前生物标志物及其在 预测疾病从临床前阶段到临床阶段的转变。行政核心将设置总体 研究方向和优先事项，监督所有与核心有关的活动，确保最佳利用ADRC 资源，并作为一种资源，以扩大AD和老龄化研究在当地，国家和超越。 在威斯康星州ADRC主任Sanjay Asthana医学博士的全面科学和行政领导下， 行政核心将继续发挥领导作用，并通过以下活动实现其目标 四大委员会。外部咨询委员会，由AD研究领域的杰出领导人组成 在威斯康星州以外的机构，并与ADRC的科学任务的专业知识，提供 关于中心总体方向和绩效的建议。执行委员会由以下人员组成： ADRC主任、副主任、管理员、核心领导人、核心联合领导人和数据领导人举行会议 每月讨论ADRC的整体功能和科学机会，审查每个核心的进展， 并解决核心内部或核心之间的问题。资源分配委员会，由ADRC组成 主任、副主任、核心领导人、管理员和特别审查员，评估所有数据请求， 获得参与者参与外部资助的研究、生前生物标本和死后 脑组织，并建议中心主任和执行委员会有关资源利用的优先事项。 行政核心强烈强调广泛利用威斯康星州ADRC资源，但 确保分发仅支持高质量的研究，同时避免有限的竞争用途 生物标本发展项目评审委员会将对所有 发展项目提交给ADRC，优先考虑那些来自初级调查员与尖端 研究和吸引外部资金的可能性很大。总体而言，行政核心将继续 发挥科学领导作用，确保威斯康星州ADRC在 新的供资周期

PROJECT SUMMARY - ADMINISTRATIVE CORE (CORE A) The overall mission of the Wisconsin Alzheimer's Disease Research Center (ADRC) is to provide an infrastructure and resources conducive to conducting cutting-edge extramurally funded research in Alzheimer's disease (AD) and related disorders, with a special focus on preclinical biomarkers of AD and their role in predicting transition from preclinical to clinical stages of the disease. The Administrative Core will set overall research directions and priorities, oversee all Core-related activities, ensure optimal utilization of the ADRC resources, and serve as a resource to expand AD and aging research locally, nationally, and beyond. Under the overall scientific and administrative leadership of Sanjay Asthana, MD, the Wisconsin ADRC Director, the Administrative Core will continue to exercise its leadership and accomplish its objectives through the activities of four major committees. The External Advisory Committee, comprised of distinguished leaders in AD research at institutions outside of Wisconsin and with expertise aligned with the scientific missions of the ADRC, provides advice concerning the overall direction and performance of the Center. The Executive Committee, comprised of the ADRC Director, Associate Director, Administrator, Core Leaders, Core Co-Leaders, and Data Leader, meets monthly to discuss the overall function and scientific opportunities for the ADRC, review each Core's progress, and resolve problems within or between Cores. The Resource Distribution Committee, composed of the ADRC Director, Associate Director, Core Leaders, Administrator, and ad hoc reviewers, evaluates all requests for data, access to participants for enrollment in externally funded studies, ante-mortem biospecimens, and postmortem brain tissue, and advises the Center Director and Executive Committee concerning resource utilization priorities. The Administrative Core places strong emphasis on wide utilization of the Wisconsin ADRC resources, but ensures distribution to support only high-quality research while avoiding competing uses for limited biospecimens. The Development Project Review Committee will perform competitive review of all the development projects submitted to the ADRC, prioritizing those from junior investigators with cutting-edge research and a strong likelihood of attracting external funding. Overall, the Administrative Core will continue to exercise scientific leadership and ensure ongoing success and excellence of the Wisconsin ADRC in the renewed cycle of funding