COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM

流感疫苗创新中心（CIVICS）合作计划

• 批准号: 10391308
• 负责人: FLORIAN KRAMMER
• 金额: $ 290万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-10 至 2025-08-04
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10391308
• 关键词: Biological Assay; Clinical Research; Clinical Trials; Development; Evaluation; Immunity; Immunologics; In Vitro; Reagent; Vaccine Design; design; efficacy testing; immunogenicity; in vivo; influenza virus strain; influenza virus vaccine; innovation; programs; universal influenza vaccine; vaccine candidate; vaccine delivery

To support the design and evaluation of innovative influenza vaccine candidates and delivery platforms that aim to achieve durable, robust and broadly protective immunity against multiple strains of influenza virus. Activities may include immunologic analyses to inform vaccine design and identify surrogates/correlates of protection; in vitro and in vivo immunogenicity and efficacy testing; assay and reagent development; and clinical studies and trials.

支持设计和评估创新的流感候选疫苗和交付平台，旨在实现对多种流感病毒株的持久、强大和广泛的保护性免疫。活动可包括免疫分析，以便为疫苗设计提供信息并确定替代物/保护性相关因素；体外和体内免疫原性和效力测试；分析和试剂开发；以及临床研究和试验。