University of Texas Adult Clinical Center

项目总结 德克萨斯大学加尔维斯顿医学分校(UTMB)和德克萨斯大学健康科学 圣安东尼奥中心(UTHSCSA)联合提议创建德克萨斯大学成人临床中心 身体活动联盟分子传感器中心(UTACC)。 我们将整合资源，结合我们的专业知识，为 关于成年人体力活动的综合研究。UTACC的具体目标是：1) 参与多中心试验的策划；2)招募450名急慢性疾病患者 运动训练研究，进行生理评估，并收集生物样本(肌肉、脂肪、 和血液)；以及3)分析和解释结果数据，并将研究结果传播给 社区。我们将使用创新工具最大限度地留住参与者并提高保真度和 遵守运动训练规程。 UTACC将对MoTrPAC产生重大影响，并推动运动科学领域的发展- 根据我们的优势、拟议研究的可行性和预期结果： UTACC的优势包括我们在进行人类分子研究方面的长期记录 锻炼的传播者；通过克劳德·D·佩珀老人分享资源和多年的人际关系 美国独立中心网络和德克萨斯州地区CTSA联盟；以及我们的成功 招收研究不足的人群，如老年人和拉美裔拉美裔美国人。 由于我们在体力活动临床试验方面的经验，UTACC的可行性很高；我们的 在收集正在进行运动研究的人类的肌肉和脂肪活检方面拥有丰富的专业知识； 以及我们获得优秀的临床研究设施，在安全的情况下进行人体研究 环境。 该计划的预期结果包括确定相关的基线分子特征 与代谢健康和体能表现有关；多组数据的整合以阐明 控制运动代谢反应的分子网络及其如何影响身体健康 性能；以及发现新的介体(蛋白质、代谢物、miRNAs)的有益效果 锻炼身体。

PROJECT SUMMARY The University of Texas Medical Branch at Galveston (UTMB) and the University of Texas Health Science Center at San Antonio (UTHSCSA) jointly propose the creation of a University of Texas Adult Clinical Center (UTACC) for the Molecular Transducers of Physical Activity Consortium (MoTrPAC). We will integrate resources and combine our expertise to provide a state-of-the-art center for comprehensive studies on physical activity in adults. The Specific Aims of the UTACC are: 1) To participate in the planning of the multi-center trial; 2) To enroll 450 participants in the acute and chronic exercise training studies, conduct physiological assessments, and collect biospecimens (muscle, adipose, and blood); and 3) To analyze and interpret outcome data and disseminate findings to the scientific community. We will use innovative tools to maximize participant retention and enhance fidelity and adherence to the exercise training protocols. The UTACC will have a significant impact on the MoTrPAC – and advance the field of exercise science – based on our strengths, feasibility of the proposed study, and expected outcomes: The strengths of the UTACC include our long-track record of performing human studies on molecular transducers of exercise; shared resources and years of networking through the Claude D. Pepper Older Americans Independence Center network and the Texas Regional CTSA Consortium; and our success with enrolling understudied populations such as older individuals and Hispanics-Latinos. The feasibility for the UTACC is high due to our experience with clinical trials on physical activity; our substantial expertise in collecting muscle and adipose biopsies in humans undergoing exercise studies; and our access to outstanding clinical research facilities in which to conduct human research in a safe environment. Expected outcomes of this program include the determination of baseline molecular signatures associated with metabolic health and physical performance; the integration of multi-omic data for the elucidation of molecular networks that control metabolic responses to exercise and how they influence physical performance; and discovery of novel mediators (proteins, metabolites, miRNAs) of the beneficial effects of exercise.