University of Texas Adult Clinical Center

项目摘要 位于加尔维斯顿的德克萨斯大学医学分支（UTMB）和德克萨斯大学健康科学 中心在圣安东尼奥（UTHSCSA）共同提议建立一个得克萨斯大学成人临床 中心（UTACC）的分子传感器的身体活动联盟（MoTrPAC）。 我们将整合资源，联合收割机，为客户提供最先进的中心， 对成年人身体活动的全面研究。UTACC的具体目标是：1） 参与多中心试验的计划; 2）在急性和慢性试验中招募450名参与者 运动训练研究，进行生理评估，并收集生物标本（肌肉，脂肪， 和血液）;和3）分析和解释结果数据，并向科学界传播研究结果。 社区我们将使用创新的工具，以最大限度地保持参与者和提高忠诚度， 遵守运动训练协议。 UTACC将对MoTrPAC产生重大影响-并推进运动科学领域- 根据我们的优势、拟议研究的可行性和预期结果： UTACC的优势包括我们在分子生物学方面进行人类研究的长期记录， 运动传感器;共享资源和多年的网络通过克劳德D。胡椒老 美国独立中心网络和得克萨斯州区域CTSA联盟;以及我们的成功 招募未充分研究的人群，如老年人和西班牙裔拉丁美洲人。 UTACC的可行性很高，因为我们在体力活动方面的临床试验经验;我们的 在进行运动研究的人体中收集肌肉和脂肪活检的大量专业知识; 以及我们可以使用优秀的临床研究设施，在安全的环境中进行人体研究。 环境 该计划的预期成果包括确定与基因组相关的基线分子特征， 与代谢健康和身体表现;多组学数据的整合， 控制运动代谢反应的分子网络，以及它们如何影响身体 性能;和发现新的介质（蛋白质，代谢物，miRNA）的有益效果， 锻炼的

PROJECT SUMMARY The University of Texas Medical Branch at Galveston (UTMB) and the University of Texas Health Science Center at San Antonio (UTHSCSA) jointly propose the creation of a University of Texas Adult Clinical Center (UTACC) for the Molecular Transducers of Physical Activity Consortium (MoTrPAC). We will integrate resources and combine our expertise to provide a state-of-the-art center for comprehensive studies on physical activity in adults. The Specific Aims of the UTACC are: 1) To participate in the planning of the multi-center trial; 2) To enroll 450 participants in the acute and chronic exercise training studies, conduct physiological assessments, and collect biospecimens (muscle, adipose, and blood); and 3) To analyze and interpret outcome data and disseminate findings to the scientific community. We will use innovative tools to maximize participant retention and enhance fidelity and adherence to the exercise training protocols. The UTACC will have a significant impact on the MoTrPAC – and advance the field of exercise science – based on our strengths, feasibility of the proposed study, and expected outcomes: The strengths of the UTACC include our long-track record of performing human studies on molecular transducers of exercise; shared resources and years of networking through the Claude D. Pepper Older Americans Independence Center network and the Texas Regional CTSA Consortium; and our success with enrolling understudied populations such as older individuals and Hispanics-Latinos. The feasibility for the UTACC is high due to our experience with clinical trials on physical activity; our substantial expertise in collecting muscle and adipose biopsies in humans undergoing exercise studies; and our access to outstanding clinical research facilities in which to conduct human research in a safe environment. Expected outcomes of this program include the determination of baseline molecular signatures associated with metabolic health and physical performance; the integration of multi-omic data for the elucidation of molecular networks that control metabolic responses to exercise and how they influence physical performance; and discovery of novel mediators (proteins, metabolites, miRNAs) of the beneficial effects of exercise.