权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

University of Texas Adult Clinical Center

德克萨斯大学成人临床中心

基本信息

批准号：
9246912
负责人：
Nicolas Musi
金额：
$ 27.28万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-12-07 至 2022-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9246912
关键词：
Acute Adherence Adipose tissue Adult Aerobic Aging American Biology Biopsy Biopsy Specimen Blood Body Composition Capsicum Catchment Area Chronic Chronic Disease Clinical Clinical Protocols Clinical Research Clinical Trials Clinical Trials Design Communities Complex Data Data Analyses Data Set Development Diabetes Mellitus Enrollment Environment Evidence based intervention Exercise Exercise Physiology Exercise Tolerance FRAP1 gene Funding Glucose Intolerance Goals Health Health Benefit Health Sciences Hispanics Human Human Resources Individual Industry Insulin Resistance Knowledge Latino Link Manuals Mediator of activation protein Medical Metabolic Metabolic Control Metabolic syndrome Methodology MicroRNAs Mission Molecular Molecular Profiling Multicenter Trials Muscle Outcome Participant Pathway interactions Phase Phenotype Physical Performance Physical activity Physiological Population Protocols documentation Public Health Randomized Recruitment Activity Research Research Infrastructure Research Personnel Resource Sharing Resources Science Skeletal Muscle Source Specific qualifier value Texas Tissues Training Transducers United States National Aeronautics and Space Administration United States National Institutes of Health Universities base bone health cohesion cohort data integration design disability disability burden exercise training experience improved innovation metabolic abnormality assessment muscle strength novel operation preclinical study programs protein metabolite research facility response sedentary strength training study population success tool

项目摘要

PROJECT SUMMARY The University of Texas Medical Branch at Galveston (UTMB) and the University of Texas Health Science Center at San Antonio (UTHSCSA) jointly propose the creation of a University of Texas Adult Clinical Center (UTACC) for the Molecular Transducers of Physical Activity Consortium (MoTrPAC). We will integrate resources and combine our expertise to provide a state-of-the-art center for comprehensive studies on physical activity in adults. The Specific Aims of the UTACC are: 1) To participate in the planning of the multi-center trial; 2) To enroll 450 participants in the acute and chronic exercise training studies, conduct physiological assessments, and collect biospecimens (muscle, adipose, and blood); and 3) To analyze and interpret outcome data and disseminate findings to the scientific community. We will use innovative tools to maximize participant retention and enhance fidelity and adherence to the exercise training protocols. The UTACC will have a significant impact on the MoTrPAC – and advance the field of exercise science – based on our strengths, feasibility of the proposed study, and expected outcomes: The strengths of the UTACC include our long-track record of performing human studies on molecular transducers of exercise; shared resources and years of networking through the Claude D. Pepper Older Americans Independence Center network and the Texas Regional CTSA Consortium; and our success with enrolling understudied populations such as older individuals and Hispanics-Latinos. The feasibility for the UTACC is high due to our experience with clinical trials on physical activity; our substantial expertise in collecting muscle and adipose biopsies in humans undergoing exercise studies; and our access to outstanding clinical research facilities in which to conduct human research in a safe environment. Expected outcomes of this program include the determination of baseline molecular signatures associated with metabolic health and physical performance; the integration of multi-omic data for the elucidation of molecular networks that control metabolic responses to exercise and how they influence physical performance; and discovery of novel mediators (proteins, metabolites, miRNAs) of the beneficial effects of exercise.

项目总结