Molecular Transducers of Physical Activity Clinical Centers (U01) - UT Health San Antonio Clinical Center

身体活动分子传感器临床中心 (U01) - UT Health 圣安东尼奥临床中心

• 批准号: 10320447
• 负责人: Nicolas Musi
• 金额: $ 209.72万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-06 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10320447
• 关键词: Acute; Address; Adult; American; Ancillary Study; Behavior; Bioinformatics; Biological; Biological Process; Biology; Biopsy; Body Composition; Cardiovascular Diseases; Characteristics; Chronic; Chronic Disease; Clinical; Clinical Trials; Collection; Data; Diabetes Mellitus; Effectiveness; Elderly; Exercise; Exposure to; Genomics; Goals; Guidelines; Health; Individual; Intervention; Intervention Studies; Intervention Trial; Laboratories; Leadership; Life Style; Link; Longevity; Longitudinal observational study; Malignant Neoplasms; Measures; Medical; Molecular; Morbidity - disease rate; Multi-Institutional Clinical Trial; Musculoskeletal; Outcome; Outcome Measure; Participant; Pathway interactions; Patient Recruitments; Pharmacotherapy; Physical Endurance; Physical activity; Physiological; Population; Positioning Attribute; Procedures; Proteomics; Protocols documentation; Public Health; Randomized; Recommendation; Research Personnel; Resources; Sample Size; Sampling; Schedule; Science; Site; Strenuous Exercise; Supervision; Testing; Tissue Sample; Tissues; Training; Training Programs; Transducers; Universities; Update; Work; behavior influence; behavioral study; cardiorespiratory fitness; clinical center; data collection methodology; endurance exercise; epigenomics; exercise intervention; exercise training; experience; fitness; lifestyle factors; metabolomics; middle age; mortality; phenotypic data; prevent; recruit; resistance exercise; response; sedentary lifestyle; strength training; transcriptomics; vigorous intensity

Project Summary/Abstract: This application is for the formation of an Adult Clinical Center in response to RFA-RM-15-015 “Molecular Transducers of Physical Activity Clinical Centers (U01)” (MoTrPAC). Physical activity is an important lifestyle behavior that has been shown to be associated with morbidity and mortality from numerous chronic diseases. This has led to current public health recommendations of 150 min/wk of moderate-intensity physical activity or 75 min/wk of vigorous physical activity to achieve significant health- related benefits, and for recommendations to engage in resistance exercise. Despite the abundance of data to support physical activity as a key lifestyle factor that can prevent, delay, or reverse the onset of a variety of health-related conditions, the specific underlying physiological mechanisms and pathways by which this occurs are not fully established. Our team of investigators is well-positioned to be an Adult Clinical Center and achieve the goals and objectives outlined in this RFA. We have the capacity in Pittsburgh to recruit, retain, train, and assess the 450 participants that are required at each Adult Clinical Center. We will recruit 450 participants at the Pittsburgh Adult Clinical Center, which will include untrained subjects who will be randomized to the intervention (72% of the sample, N=324) or control condition (12% of the sample, N=54) and trained subjects (16% of the sample, N=72). Untrained participants will be randomized to one of the following for a period of 12 weeks: 1) Control (UN- CON) that will maintain their current level of physical activity; 2) Moderate-Intensity Physical Activity (UN-MOD) that will progress to 150 min/wk of supervised moderate-intensity endurance physical activity; 3) Vigorous- Intensity Physical Activity (UN-VIG) that will progress to 75 min/wk of supervised vigorous-intensity endurance physical activity; 4) Resistance Training (UN-RES) that will engage in supervised resistance exercise. In addition, exercise trained participants (50% endurance trained, 50% resistance trained) will be recruited and will undergo baseline testing only. Thus, we propose to form an Adult Clinical Center at the University of Pittsburgh to achieve the following objectives of MoTrPAC: 1. To recruit, retain, and collect data on 450 participants (378 untrained and 72 trained) at the Pittsburgh site that will contribute to the 2,700 total participants across the Adult Clinical Centers. 2. To demonstrate the effectiveness of our training program, we will compare changes in cardiorespiratory fitness in untrained participants randomized to 12-weeks of moderate-intensity endurance exercise training (UN-MOD), vigorous-intensity endurance exercise training (UN-VIG), resistance training (UN-RES) or control (UN-CON). 3. To demonstrate the effectiveness of our training program, we will compare changes in musculoskeletal fitness in untrained participants randomized to 12-weeks of UN-MOD, UN-VIG, UN-RES, or UN-CON. 4. To compare cardiorespiratory fitness in participants recruited as endurance trained to participants randomized to UN-MOD and UN-VIG following 12 weeks of training. 5. To compare musculoskeletal fitness in participants recruited as endurance trained to participants randomized to UN-RES following 12 weeks of training. 6. To collect phenotypic data that will allow for characterization of the study participants. These data will be provided to the Coordinating Center and utilized by the Bioinformatics Center, Metabolomics and Proteomics Analysis Sites, and Genomics, Epigenomics, and Transcriptomics Analysis Sites. 7. To collect biological data according to the study protocol that will provide data to examine the molecular and cellular transducers in response to acute and chronic exposure to endurance or resistance exercise training. These data will be provided to the Coordinating Center and utilized by the Bioinformatics Center, Metabolomics and Proteomics Analysis Sites, and Genomics, Epigenomics, and Transcriptomics Sites.

项目摘要/摘要： 该应用是用于响应RFA-RM-15-015的成人临床中心的形成 体育活动临床中心（U01）的传感器”（MOTRPAC）。 体育活动是一种重要的生活方式行为，已证明与发病率相关 许多慢性疾病的死亡率。这导致当前的公共卫生建议为150分钟/周 现代强度的体育活动或75分钟/周的剧烈体育锻炼以实现重要的健康 相关的好处，并为参与抵抗运动的建议。尽管数据抽象为 支持体育锻炼是可以预防，延迟或扭转各种各样的重要生活方式因素 与健康相关的条件，特定的潜在生理机制和途径发生 没有完全确定。 我们的调查人员团队的位置很好，是成人临床中心，并实现目标和目标 此RFA中概述的目标。我们在匹兹堡有能力招募，保留，培训和评估450 每个成人临床中心需要的参与者。我们将在匹兹堡成人招募450名参与者 临床中心将包括未经训练的受试者，他们将被随机分配给干预措施（72％ 样本，n = 324）或对照条件（占样本的12％，n = 54）和受过训练的受试者（占样本的16％，n = 72）。 未经培训的参与者将在12周期间随机分配到以下一项：1）控制（UN- 骗局将保持其目前的体育锻炼水平； 2）中等强度的体育活动（UN模型） 这将发展到监督现代强度的耐力体育锻炼的150分钟/周； 3）有力 - 强度体育锻炼（UN-VIG）将发展为75分钟/周的监督剧烈强度耐力 体育锻炼； 4）将进行有监督的抵抗运动的抵抗训练（UN-RES）。在 此外，将招募经过运动训练的参与者（受过50％的耐力训练，50％的抵抗运动）将被招募，并将 仅接受基线测试。 这就是我们建议在匹兹堡大学组建一个成人临床中心，以实现以下 Motrpac的目标： 1。在匹兹堡网站招募，保留和收集450名参与者（378名未经培训和72名培训）的数据 这将为成人临床中心的2700名参与者提供贡献。 2。为了证明我们的培训计划的有效性，我们将比较心肺的变化 未经训练的参与者的适应性随机到12周的现代强度耐力运动训练 （UN-MOD），剧烈的强度耐力运动训练（UN-VIG），抵抗训练（UN-RES）或控制 （UN-CON）。 3。为了证明我们的培训计划的有效性，我们将比较肌肉骨骼的变化 未经训练的参与者的适应性随机分配到12周的UN-MOD，UN-VIG，UN-RES或UN-CON。 4。比较参加参与者的耐力的参与者中的心肺健康 在训练12周后，随机分配至未模型和UN-VIG。 5。比较参加参与者的耐力的参与者中的肌肉骨骼适应性 在培训12周后将其取消分辨。 6。收集表型数据，以允许研究参与者的表征。这些数据将是 提供给协调中心，并由生物信息学中心，代谢组学和蛋白质组学使用 分析位点以及基因组学，表观基因组学和转录组学分析位点。 7。根据研究方案收集生物学数据，该方案将提供数据以检查分子和 响应急性和长期暴露于耐力或耐药性运动训练的细胞换能器。 这些数据将提供给协调中心，并由生物信息学中心使用， 代谢组学和蛋白质组学分析位点以及基因组学，表观基因组学和转录组学部位。