Molecular Transducers of Physical Activity Clinical Centers (U01) - Cedars -Sinai Medical Center

身体活动分子传感器临床中心 (U01) - Cedars -Sinai Medical Center

• 批准号: 10782038
• 负责人: Nicolas Musi
• 金额: $ 39.6万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-06 至 2023-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10782038
• 关键词: Molecular; Transducers; Physical; Activity; Clinical

Project Summary/Abstract: This application is for the formation of an Adult Clinical Center in response to RFA-RM-15-015 “Molecular Transducers of Physical Activity Clinical Centers (U01)” (MoTrPAC). Physical activity is an important lifestyle behavior that has been shown to be associated with morbidity and mortality from numerous chronic diseases. This has led to current public health recommendations of 150 min/wk of moderate-intensity physical activity or 75 min/wk of vigorous physical activity to achieve significant health- related benefits, and for recommendations to engage in resistance exercise. Despite the abundance of data to support physical activity as a key lifestyle factor that can prevent, delay, or reverse the onset of a variety of health-related conditions, the specific underlying physiological mechanisms and pathways by which this occurs are not fully established. Our team of investigators is well-positioned to be an Adult Clinical Center and achieve the goals and objectives outlined in this RFA. We have the capacity in Pittsburgh to recruit, retain, train, and assess the 450 participants that are required at each Adult Clinical Center. We will recruit 450 participants at the Pittsburgh Adult Clinical Center, which will include untrained subjects who will be randomized to the intervention (72% of the sample, N=324) or control condition (12% of the sample, N=54) and trained subjects (16% of the sample, N=72). Untrained participants will be randomized to one of the following for a period of 12 weeks: 1) Control (UN- CON) that will maintain their current level of physical activity; 2) Moderate-Intensity Physical Activity (UN-MOD) that will progress to 150 min/wk of supervised moderate-intensity endurance physical activity; 3) Vigorous- Intensity Physical Activity (UN-VIG) that will progress to 75 min/wk of supervised vigorous-intensity endurance physical activity; 4) Resistance Training (UN-RES) that will engage in supervised resistance exercise. In addition, exercise trained participants (50% endurance trained, 50% resistance trained) will be recruited and will undergo baseline testing only. Thus, we propose to form an Adult Clinical Center at the University of Pittsburgh to achieve the following objectives of MoTrPAC: 1. To recruit, retain, and collect data on 450 participants (378 untrained and 72 trained) at the Pittsburgh site that will contribute to the 2,700 total participants across the Adult Clinical Centers. 2. To demonstrate the effectiveness of our training program, we will compare changes in cardiorespiratory fitness in untrained participants randomized to 12-weeks of moderate-intensity endurance exercise training (UN-MOD), vigorous-intensity endurance exercise training (UN-VIG), resistance training (UN-RES) or control (UN-CON). 3. To demonstrate the effectiveness of our training program, we will compare changes in musculoskeletal fitness in untrained participants randomized to 12-weeks of UN-MOD, UN-VIG, UN-RES, or UN-CON. 4. To compare cardiorespiratory fitness in participants recruited as endurance trained to participants randomized to UN-MOD and UN-VIG following 12 weeks of training. 5. To compare musculoskeletal fitness in participants recruited as endurance trained to participants randomized to UN-RES following 12 weeks of training. 6. To collect phenotypic data that will allow for characterization of the study participants. These data will be provided to the Coordinating Center and utilized by the Bioinformatics Center, Metabolomics and Proteomics Analysis Sites, and Genomics, Epigenomics, and Transcriptomics Analysis Sites. 7. To collect biological data according to the study protocol that will provide data to examine the molecular and cellular transducers in response to acute and chronic exposure to endurance or resistance exercise training. These data will be provided to the Coordinating Center and utilized by the Bioinformatics Center, Metabolomics and Proteomics Analysis Sites, and Genomics, Epigenomics, and Transcriptomics Sites.

项目摘要/摘要： 此应用程序用于建立一个成人临床中心，以响应RFA-RM-15-015“分子 体力活动临床中心的传感器(U01)“(MoTrPAC)。 体力活动是一种重要的生活方式行为，已被证明与发病率和 死于多种慢性病。这导致了目前的公共卫生建议为150分钟/周 中等强度的体力活动或75分钟/周的剧烈体力活动，以实现显著的健康- 相关的好处，以及参与抵抗运动的建议。尽管有大量的数据 支持体力活动作为一种关键的生活方式因素，可以预防、延迟或逆转各种 与健康相关的疾病，具体的潜在生理机制和发生的途径 还没有完全建立起来。 我们的调查团队处于有利地位，可以成为成人临床中心，并实现目标和 本RFA中概述的目标。我们有能力在匹兹堡招聘、留住、培训和评估450名员工 每个成人临床中心所要求的参与者。我们将在匹兹堡成人酒店招募450名参与者 临床中心，将包括将随机接受干预的未经培训的受试者(72%的 样本，N=324)或对照条件(样本的12%，N=54)和训练对象(样本的16%，N=72)。 未经培训的参与者将被随机分配到以下组之一，为期12周：1)对照组(联合国- 2)中等强度的体力活动(UN-MOD) 这将发展到150分钟/周的有监督的中等强度耐力体力活动；3)剧烈- 强度体力活动(UN-VIG)，将进展到75分钟/周的监督高强度耐力 体力活动；4)阻力训练(UN-RES)，将在监督下进行阻力训练。在……里面 此外，将招募经过运动训练的参与者(50%耐力训练，50%抵抗训练)，并将 仅接受基线测试。 因此，我们建议在匹兹堡大学成立一个成人临床中心，以实现以下目标 MoTrPAC的目标： 1.在匹兹堡现场招募、保留和收集450名参与者(378名未经培训，72名接受培训)的数据 这将有助于成人临床中心的2700名参与者。 2.为了证明我们培训计划的有效性，我们将比较心肺功能的变化 未经训练的参与者随机接受12周的中等强度耐力运动训练的健康状况 (UN-MOD)、大强度耐力运动训练(UN-VIG)、抵抗训练(UN-RES)或对照 (联合国大会)。 3.为了证明我们培训计划的有效性，我们将比较肌肉骨骼的变化 未受过训练的参与者的健康状况被随机分为联合国-MOD、联合国-VIG、联合国-RES或联合国-CON。 4.比较作为耐力训练招募的参与者与参与者的心肺功能 在12周的培训后，被随机分配到联合国国防部和联合国志愿人员组。 5.比较招募参加耐力训练的参与者和随机抽取的参与者的肌肉骨骼健康状况 在接受了12周的培训后，联合国人权事务高级专员办事处将继续向联合国人权高专办提供培训。 6.收集表型数据，以确定研究参与者的特征。这些数据将是 提供给协调中心，并由生物信息学中心、代谢组学和蛋白质组学使用 分析站点，以及基因组学、表观基因组学和转录组分析站点。 7.根据研究协议收集生物数据，该协议将提供数据以检查分子和 对急性和慢性耐力或阻力运动训练作出反应的细胞转导。 这些数据将被提供给协调中心并由生物信息学中心使用， 代谢组学和蛋白质组学分析站点，以及基因组学、表观基因组学和转录组学站点。