Molecular Transducers of Physical Activity Clinical Centers (U01) - Cedars -Sinai Medical Center
身体活动分子传感器临床中心 (U01) - Cedars -Sinai Medical Center
基本信息
- 批准号:10782038
- 负责人:
- 金额:$ 39.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-12-06 至 2023-09-22
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Project Summary/Abstract:
This application is for the formation of an Adult Clinical Center in response to RFA-RM-15-015 “Molecular
Transducers of Physical Activity Clinical Centers (U01)” (MoTrPAC).
Physical activity is an important lifestyle behavior that has been shown to be associated with morbidity and
mortality from numerous chronic diseases. This has led to current public health recommendations of 150 min/wk
of moderate-intensity physical activity or 75 min/wk of vigorous physical activity to achieve significant health-
related benefits, and for recommendations to engage in resistance exercise. Despite the abundance of data to
support physical activity as a key lifestyle factor that can prevent, delay, or reverse the onset of a variety of
health-related conditions, the specific underlying physiological mechanisms and pathways by which this occurs
are not fully established.
Our team of investigators is well-positioned to be an Adult Clinical Center and achieve the goals and
objectives outlined in this RFA. We have the capacity in Pittsburgh to recruit, retain, train, and assess the 450
participants that are required at each Adult Clinical Center. We will recruit 450 participants at the Pittsburgh Adult
Clinical Center, which will include untrained subjects who will be randomized to the intervention (72% of the
sample, N=324) or control condition (12% of the sample, N=54) and trained subjects (16% of the sample, N=72).
Untrained participants will be randomized to one of the following for a period of 12 weeks: 1) Control (UN-
CON) that will maintain their current level of physical activity; 2) Moderate-Intensity Physical Activity (UN-MOD)
that will progress to 150 min/wk of supervised moderate-intensity endurance physical activity; 3) Vigorous-
Intensity Physical Activity (UN-VIG) that will progress to 75 min/wk of supervised vigorous-intensity endurance
physical activity; 4) Resistance Training (UN-RES) that will engage in supervised resistance exercise. In
addition, exercise trained participants (50% endurance trained, 50% resistance trained) will be recruited and will
undergo baseline testing only.
Thus, we propose to form an Adult Clinical Center at the University of Pittsburgh to achieve the following
objectives of MoTrPAC:
1. To recruit, retain, and collect data on 450 participants (378 untrained and 72 trained) at the Pittsburgh site
that will contribute to the 2,700 total participants across the Adult Clinical Centers.
2. To demonstrate the effectiveness of our training program, we will compare changes in cardiorespiratory
fitness in untrained participants randomized to 12-weeks of moderate-intensity endurance exercise training
(UN-MOD), vigorous-intensity endurance exercise training (UN-VIG), resistance training (UN-RES) or control
(UN-CON).
3. To demonstrate the effectiveness of our training program, we will compare changes in musculoskeletal
fitness in untrained participants randomized to 12-weeks of UN-MOD, UN-VIG, UN-RES, or UN-CON.
4. To compare cardiorespiratory fitness in participants recruited as endurance trained to participants
randomized to UN-MOD and UN-VIG following 12 weeks of training.
5. To compare musculoskeletal fitness in participants recruited as endurance trained to participants randomized
to UN-RES following 12 weeks of training.
6. To collect phenotypic data that will allow for characterization of the study participants. These data will be
provided to the Coordinating Center and utilized by the Bioinformatics Center, Metabolomics and Proteomics
Analysis Sites, and Genomics, Epigenomics, and Transcriptomics Analysis Sites.
7. To collect biological data according to the study protocol that will provide data to examine the molecular and
cellular transducers in response to acute and chronic exposure to endurance or resistance exercise training.
These data will be provided to the Coordinating Center and utilized by the Bioinformatics Center,
Metabolomics and Proteomics Analysis Sites, and Genomics, Epigenomics, and Transcriptomics Sites.
项目总结/文摘:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Nicolas Musi的其他文献
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{{ truncateString('Nicolas Musi', 18)}}的其他基金
Single nuclei RNA-seq to map adipose cellular populations and senescet cells in older subjects
单核 RNA-seq 绘制老年受试者的脂肪细胞群和衰老细胞图谱
- 批准号:
10361123 - 财政年份:2022
- 资助金额:
$ 39.6万 - 项目类别:
Single nuclei RNA-sequencing to map adipose cellular populations and senescent cells in older subjects
单核 RNA 测序绘制老年受试者的脂肪细胞群和衰老细胞图谱
- 批准号:
10815427 - 财政年份:2022
- 资助金额:
$ 39.6万 - 项目类别:
Molecular Transducers of Physical Activity Consortium Adult Clinical Center
体力活动联盟成人临床中心分子传感器
- 批准号:
10842074 - 财政年份:2016
- 资助金额:
$ 39.6万 - 项目类别:
Molecular Transducers of Physical Activity Clinical Centers (U01) - UT Health San Antonio Clinical Center
身体活动分子传感器临床中心 (U01) - UT Health 圣安东尼奥临床中心
- 批准号:
10531636 - 财政年份:2016
- 资助金额:
$ 39.6万 - 项目类别:
Molecular Transducers of Physical Activity Clinical Centers (U01) - UT Health San Antonio Clinical Center
身体活动分子传感器临床中心 (U01) - UT Health 圣安东尼奥临床中心
- 批准号:
10320447 - 财政年份:2016
- 资助金额:
$ 39.6万 - 项目类别:
相似海外基金
Supplement Proposal-A Pediatric Clinical Center for Molecular Transducers of Physical Activity (MoTrPAC): Towards a Molecular Map of Exercise in the Pediatric Origins of Health Across the Lifespan
补充提案-体力活动分子传感器儿科临床中心 (MoTrPAC):构建儿科全生命周期健康起源的运动分子图谱
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10448484 - 财政年份:2020
- 资助金额:
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Molecular Transducers of Physical Activity: Liver Adaptations Drive Brain Benefits
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- 批准号:
10264908 - 财政年份:2020
- 资助金额:
$ 39.6万 - 项目类别:
Molecular Transducers of Physical Activity Consortium Coordinating Center
体力活动分子传感器联盟协调中心
- 批准号:
10840609 - 财政年份:2017
- 资助金额:
$ 39.6万 - 项目类别:
A Pediatric Clinical Center for Molecular Transducers of Physical Activity (MoTrPAC): Towards a Molecular Map of Exercise in the Pediatric Origins of Health Across the Lifespan
体力活动分子传感器儿科临床中心 (MoTrPAC):绘制儿科全生命周期健康起源的运动分子图谱
- 批准号:
10391626 - 财政年份:2016
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Molecular Transducers of Physical Activity and Health: NC Consortium Clinical Site
身体活动与健康的分子传感器:NC 联盟临床站点
- 批准号:
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- 资助金额:
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Animal Studies Investigating Molecular Transducers of Physical Activity
调查体力活动分子传感器的动物研究
- 批准号:
10770264 - 财政年份:2016
- 资助金额:
$ 39.6万 - 项目类别:
Molecular Transducers of Physical Activity Consortium Adult Clinical Center
体力活动联盟成人临床中心分子传感器
- 批准号:
10842074 - 财政年份:2016
- 资助金额:
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Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center
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- 批准号:
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- 批准号:
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