Key Facility Upgrades for the Rutgers University RBL.

中文摘要 罗格斯大学区域生物防护实验室（RBL）作为一个中心设施， 生物安全三级（BSL 3）研究的学术和商业实体在罗格斯大学， 美国东北部，以及更远的地方。大量用于高威胁病原体研究，该设施现在 面对老化的系统，包括涉及电气、地板、通风、安全和设备的系统。 这些缺陷使设施在需要维修或升级时面临长时间关闭的风险， 威胁到我们吸引和留住一流科学家的能力。这项建议旨在纠正这些不足之处， 将罗格斯RBL恢复为最先进的设施和关键的区域资源。这将在 以下目标：1.将第二根馈电电缆安装到现有的双端开关柜中。2.安装 新的高性能环氧地坪系统在新的基板。3.升级约翰逊控制大楼 服务于RBL HVAC设备的管理系统（BMS）。4.取代现有的皮带驱动高羽流 排气扇5.用风扇墙阵列替换现有的空气处理装置（AHU-1、2和3）送风机。6.安装新 所有入口都有监视器。7.升级视频监控系统。8.购买便携式汽化氢气 过氧化氢（VH 2 O2）系统，以实现选择性的房间和设备去污。9.购买并安装 最先进的细胞分选仪。10.购买QIAcube仪器以取代手动RNA/DNA 提取。总之，这些升级和新的购买将确保罗格斯RBL能够继续 它的使命是支持本十年及以后的高威胁病原体研究。

PROTECT ABSTRACT The Rutgers University Regional Biocontainment Laboratory (RBL) serves as a central facility to perform biosafety level three (BSL3) research for academic and commercial entities within Rutgers University, the Northeast United States, and beyond. Heavily used for high-threat pathogen research, this facility is now confronted with aging systems including those involved in electrical, flooring, ventilation, security and equipment. These deficiencies place the facility at risk for prolonged shutdowns when repairs or upgrades are needed and threaten our ability to attract and retain first class scientists. This proposal seeks to rectify these deficiencies, returning the Rutgers RBL to a state-of-the-art facility and a critical regional resource. This will be performed in the following aims: 1. Install a second electric feeder cable into the existing double-ended switchgear. 2. Install new high performance epoxy floor system on new substrate. 3. Upgrade the Johnson Controls Building Management System (BMS) serving the RBL HVAC equipment. 4. Replace the existing belt-driven high plume exhaust fans. 5. Replace existing air handling unit (AHU-1,2 & 3) supply fans with fan wall arrays. 6. Install new keypads at all entry points. 7. Upgrade the video surveillance system. 8. Purchase a portable vaporized hydrogen peroxide (VH2O2) system to enable selective room and equipment decontamination. 9. Purchase and install a new state of the art multicolor cell sorter. 10. Purchase a QIAcube instrument to replace manual RNA/DNA extractions. Together, these upgrades and new purchases will ensure that the Rutgers RBL is able to continue its mission to support high-threat pathogen research for the current decade and beyond.