Key Facility Upgrades for the Rutgers University RBL.

保护摘要 罗格斯大学区域生物遏制实验室(RBL)作为中央设施执行 罗格斯大学内学术和商业实体的生物安全三级(BSL3)研究 美国东北部，以及更远的地方。这个设施主要用于高威胁病原体的研究，现在 面临老化的系统，包括涉及电力、地板、通风、安全和设备的系统。 这些缺陷使设施在需要维修或升级时面临长时间关闭的风险， 威胁到我们吸引和留住一流科学家的能力。这项建议旨在纠正这些缺陷， 将罗格斯RBL归还给一个最先进的设施和一个关键的地区资源。这将在以下时间执行 目标如下：1.在现有的双端开关柜中安装第二条馈线电缆。2.安装 新基板上的新型高性能环氧地坪系统。3.江森自控大楼升级改造 为RBL暖通空调设备服务的管理系统(BMS)。4.取代现有皮带驱动的高烟柱 排气扇。5.将现有的空气处理机组(AHU-1、2和3)送风机更换为风机墙阵列。6.安装新的 所有入口点都有键盘。7.升级视频监控系统。8.购买便携式汽化氢气 过氧化氢(VH_2O_2)系统，以实现选择性房间和设备的净化。9.购买并安装 最新的多色细胞分选机。10.购买QIAcube仪器以取代手动RNA/DNA 摘录。总之，这些升级和新的购买将确保罗格斯RBL能够继续 其使命是支持本十年及以后的高威胁病原体研究。

PROTECT ABSTRACT The Rutgers University Regional Biocontainment Laboratory (RBL) serves as a central facility to perform biosafety level three (BSL3) research for academic and commercial entities within Rutgers University, the Northeast United States, and beyond. Heavily used for high-threat pathogen research, this facility is now confronted with aging systems including those involved in electrical, flooring, ventilation, security and equipment. These deficiencies place the facility at risk for prolonged shutdowns when repairs or upgrades are needed and threaten our ability to attract and retain first class scientists. This proposal seeks to rectify these deficiencies, returning the Rutgers RBL to a state-of-the-art facility and a critical regional resource. This will be performed in the following aims: 1. Install a second electric feeder cable into the existing double-ended switchgear. 2. Install new high performance epoxy floor system on new substrate. 3. Upgrade the Johnson Controls Building Management System (BMS) serving the RBL HVAC equipment. 4. Replace the existing belt-driven high plume exhaust fans. 5. Replace existing air handling unit (AHU-1,2 & 3) supply fans with fan wall arrays. 6. Install new keypads at all entry points. 7. Upgrade the video surveillance system. 8. Purchase a portable vaporized hydrogen peroxide (VH2O2) system to enable selective room and equipment decontamination. 9. Purchase and install a new state of the art multicolor cell sorter. 10. Purchase a QIAcube instrument to replace manual RNA/DNA extractions. Together, these upgrades and new purchases will ensure that the Rutgers RBL is able to continue its mission to support high-threat pathogen research for the current decade and beyond.