Supplement to G20AI67347 to complete critical upgrades to the Rutgers RBL

G20AI67347 的补充，以完成罗格斯 RBL 的关键升级

• 批准号: 10631469
• 负责人: David Alland
• 金额: $ 191.33万
• 依托单位: RBHS-NEW JERSEY MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-22 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10631469
• 关键词: Aerosols; Animal Experiments; Autopsy; Biochemistry; COVID-19; Clinic; Clinical; Computer Security; Custom; Dental Schools; Equipment; Faculty; Fees; Floor; Funding; Grant; Housing; Individual; Institutes; Intention; Laboratories; Location; Microbiology; Molecular Genetics; New Jersey; Oryctolagus cuniculus; Parents; Procedures; Public Health; Research; Research Institute; Research Personnel; Resources; Rodent; Running; Scientist; Technology; Training; Tuberculosis; United States National Institutes of Health; Universities; University Hospitals; Walking; Work; animal care; biosafety level 3 facility; cost; design; experimental study; international center; medical schools; member; pathogen; public health research; tissue culture

Overview of the RBL. The Rutgers RBL is located at 225 Warren Street in Newark, New Jersey. This location is within a few blocks of the New Jersey Institute of Technology (NJIT) and the Rutgers – Newark main campuses and a seven-minute walk from the Rutgers – New Jersey Medical and Dental School’s campus and the adjoining University Hospital. The RBL is physically attached to the International Center for Public Health (ICPH) building. The RBL provides > 50% of the BSL3 laboratory and BSL3 vivarium (ABSL3) space to the Rutgers campuses. This capacity is augmented by the ICPH building, which also contains additional BSL3 and ABSL3 space that is run along with the RBL as a single facility by the RBL Director, Dr. David Alland. The ICPH houses the Public Health Research Institute, the Rutgers – New Jersey Medical School Department of Microbiology, Biochemistry and Molecular Genetics, and the International Center for Tuberculosis Excellence. A Tuberculosis Clinic is situated in clinical space on the ICPH first floor. Together the facilities and activities in the ICPH building support and augment research performed in the RBL, and investigators performing high threat pathogen research make use of the resources available in the RBL. The first floor of the RBL is fully dedicated as an ABSL3 facility, which includes 6 procedure/housing suites for rodents and rabbits including housing rooms, custom-designed biosafety enclosures, tissue culture labs, procedure rooms, dedicated rooms for aerosol challenge, and a necropsy room. Animal care is supported by per diem fees, while most of the animal experiments are performed by scientists who are certified to work in the facility and supported by individual NIH grants. A new COVID-19 core within the ABSL3 includes BSL3 trained staff who can perform COVID-19 related experiments requiring BSL3 facilities for scientists who are not able to work in the BSL3 by themselves. This core is mostly supported by Rutgers University funds, with the intention to transition this core to eventually be self-sustaining financially. The second floor of the RBL is split equally between BSL3 Lab space and Biosafety Level 2 (BSL2) resident labs and support space, which are headed by several faculty members. The new COVID-19 BSL3 core also uses the facilities on the second floor RBL for COVID-19 core studies.

RBL概述。罗格斯RBL位于新泽西纽瓦克沃伦街225号。此位置 距离新泽西理工学院（NJIT）和罗格斯-纽瓦克主校区只有几个街区 从罗格斯-新泽西医学和牙科学校的校园和毗邻的 大学医院。RBL与国际公共卫生中心（ICPH）大楼相连。 RBL为罗格斯大学校园提供了超过50%的BSL 3实验室和BSL 3动物园（ABSL 3）空间。 ICPH大楼增加了这一能力，该大楼还包含额外的BSL 3和ABSL 3空间， 由RBL主任大卫·阿兰德博士沿着与RBL一起作为单一机构运行。ICPH容纳公众 健康研究所，罗格斯-新泽西医学院微生物学，生物化学系 和分子遗传学，以及国际结核病卓越中心。结核病诊所是 位于ICPH一楼的临床空间。在ICPH建筑支持的设施和活动一起 并加强在RBL进行的研究，进行高威胁病原体研究的研究人员使 使用RBL中的可用资源。 RBL的一楼完全专用于ABSL 3设施，其中包括6个程序/住房套房 用于啮齿动物和兔子，包括饲养室，定制设计的生物安全围栏，组织培养实验室， 手术室、气溶胶激发专用室和尸检室。动物护理由每 虽然大多数动物实验都是由有资格在实验室工作的科学家进行的， 设施并得到NIH个人赠款的支持。ABSL 3中的新COVID-19核心包括BSL 3培训 能够为无法进行BSL 3设施的科学家进行COVID-19相关实验的工作人员 在BSL 3中工作。该核心主要由罗格斯大学基金支持，其目的是 将这一核心转变为最终在财政上自我维持。RBL的第二层是平分的 BSL 3实验室空间和生物安全2级（BSL 2）常驻实验室和支持空间之间的联系，由 几位教师。新的COVID-19 BSL 3核心也使用二楼RBL的设施， COVID-19核心研究。