PROSPECT: Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic Disease Trends

前景：波多黎各社会心理、环境和慢性病趋势观察研究

• 批准号: 10393805
• 负责人: JOSIEMER MATTEI
• 金额: $ 13.85万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10393805
• 关键词: Administrative Supplement; Adult; Age; Biological Markers; Blood Glucose; Blood Pressure; Blood specimen; Boston; Calcium; Chronic Disease; Clinical; Clinical Trials; Data; Diabetes Mellitus; Diastolic blood pressure; Diet; Dietary Supplementation; Dietary intake; Disease; Dose; Ethnic Origin; Food; Frequencies; Glucose; Glycosylated hemoglobin A; Goals; Health; High Prevalence; Hypertension; Incidence; Individual; Infrastructure; Insulin; Insulin Resistance; Intake; Intervention; Island; Knowledge; Link; Magnesium; Measures; Mg supplementation; Micronutrients; Minerals; Multivitamin; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Nutrient; Observational Study; Participant; Patient Recruitments; Pattern; Physiological; Placebos; Plasma; Policies; Population; Potassium; Prediabetes syndrome; Prevalence; Psychosocial Assessment and Care; Public Health; Puerto Rican; Puerto Rico; Questionnaires; Recommendation; Reporting; Role; Seminal; Serum; Sodium; Supplementation; Underserved Population; United States; Vitamin B 12; Vitamin B6; Vitamin D; Vitamin D supplementation; Vitamins; blood pressure reduction; cardiometabolism; cohort; diabetes risk; dietary; dietary guidelines; dietary supplements; disorder prevention; disparity reduction; epidemiology study; good diet; high risk; improved; prevent; programs; recruit; sex; trend

Project Summary In 2019, the United States (US) territory of Puerto Rico (PR) had the highest prevalence of type 2 diabetes and disparately higher hypertension prevalence compared to the US population. Strong evidence supports that these cardiometabolic conditions can be prevented with a healthy diet. However, we have documented suboptimal diet quality and inadequate age- and sex-specific intake for magnesium (Mg), calcium (Ca), potassium (K), and vitamin D (vitD) among adults in PR. Dietary supplementation may significantly lower the inadequacy of several nutrients; however, our preliminary data among adults in PR suggest moderate-to-low use of dietary supplements. Importantly, dietary supplement use may alter serum concentration of micronutrients, creating the need to determine correlation of intake with physiological status. Data on supplement use are scarce for PR, and it remains unknown why they choose to use supplements, patterns of use including frequency and dose, and how these are associated with physiological status as well as with hypertension and diabetes, as evidence suggests selected nutrients may help prevent these conditions. Our overall goal is to identify use of dietary supplements which may relate to current cardiometabolic conditions, and inform dietary guidelines and future research needs aimed at reducing cardiometabolic disparities in PR. We will leverage the established infrastructure of PROSPECT: Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic disease Trends', a cohort of adults (30-75y) conducted across the island. We administer a validated food frequency questionnaire with some questions on supplement use, measure blood pressure, and analyze glucose markers from blood samples. Our proposal directly responds to this Administrative Supplement by adding a comprehensive supplement use questionnaire for analysis of association with blood pressure and diabetes markers, and analysis of serum Mg, vitD, vitB6, and vitB12 for correlation with supplement use, in the next 1,000 recruited participants. Our specific aims are to (1) estimate prevalence of use, frequency, duration, dose, and reasons for using dietary supplements using a questionnaire; (2) determine correlation between intake from supplement use of selected vitamins and minerals with serum biomarkers; and (3) determine associations between dietary use of supplements for Mg, vitD, vit6 and vitB12 and blood pressure and diabetes markers (i.e., plasma glucose, insulin, HOMA-IR, and hemoglobin A1c). This study will identify use of dietary supplements in PR – especially those linked to cardiometabolic conditions – to inform tailored public health messages and programs to effectively improve cardiometabolic health. The newly collected data will generate knowledge on how and why adults use dietary supplements, and which nutrient supplements may contribute to cardiometabolic health, and be possible targets for interventions, policies, or clinical recommendations with the goal of reducing cardiometabolic disparities.

项目摘要 2019年，美国属地波多黎各的2型糖尿病患病率最高 与美国人口相比，高血压患病率也高得多。强有力的证据支持这一点 这些心脏代谢疾病可以通过健康的饮食来预防。然而，我们已经记录了 不理想的饮食质量和特定年龄和性别的镁(Mg)、钙(Ca)、 钾(K)、维生素D(VitD)。膳食补充剂可能会显著降低 几种营养素不足；然而，我们在PR成人中的初步数据显示为中到低 使用膳食补充剂。重要的是，膳食补充剂的使用可能会改变血清中 微量营养素，因此需要确定摄入量与生理状态的相关性。数据在 对于公关来说，补充剂的使用很少，而且还不清楚他们为什么选择使用补充剂，模式 使用，包括频率和剂量，以及这些与生理状态以及 高血压和糖尿病，因为有证据表明，精选的营养素可能有助于预防这些情况。 我们的总体目标是确定可能与当前心脏代谢有关的膳食补充剂的使用 条件，并告知饮食指南和未来旨在减少心脏代谢的研究需要 公关方面的差距。我们将利用Prospects的现有基础设施：波多黎各观察站 心理社会、环境和慢性病趋势的研究--对30-75岁的成年人进行的队列研究 在整个岛上。我们进行了一份有效的食物频率调查问卷，其中包括一些补充问题。 使用，测量血压，并分析血液样本中的血糖标志物。我们的建议直接回应了 在本行政副刊中，增加了一份全面的补充问卷，用于分析 高血压与糖尿病标志物的关系及血清镁、维生素D、维生素B6、维生素B12的分析 与补充剂使用的相关性，在接下来的1,000名招募参与者中。我们的具体目标是(1)估计 使用问卷调查的使用情况、频率、持续时间、剂量和使用膳食补充剂的原因； (2)确定补充维生素和矿物质的摄入量与血清的相关性 生物标志物；以及(3)确定膳食中补充镁、维生素D、维生素6和维生素B12之间的关系 以及血压和糖尿病标志物(即血糖、胰岛素、HOMA-IR和血红蛋白A1c)。 这项研究将确定营养补充剂在PR中的使用情况--特别是那些与心脏代谢有关的补充剂 条件-告知量身定做的公共卫生信息和计划，以有效改善心脏代谢 健康。新收集的数据将产生关于成年人如何以及为什么使用膳食补充剂的知识，以及 哪些营养补充剂可能有助于心脏代谢健康，并可能成为 旨在减少心脏代谢差异的干预措施、政策或临床建议。